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Pediatric Nephrology
Published in: Pediatric Nephrology 8/2006

01-08-2006 | Original Article

Reduction of left ventricular hypertrophy in children undergoing hemodialysis

Authors: Tim Ulinski, Julie Genty, Christine Viau, Isabelle Tillous-Borde, Georges Deschênes

Published in: Pediatric Nephrology | Issue 8/2006

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Abstract

Left ventricular hypertrophy (LVH) is related to a 1,000-fold increased risk of cardiovascular morbidity and mortality in young adults with end-stage renal disease (ESRD) treated with hemodialysis (HD) or peritoneal dialysis. We report a series of 17 children (5 girls, 12 boys), with a median (range) age of 11 (2–18) years, all treated by HD, who presented with an increased left ventricular mass (LVM) index of 54.8±4.5 g/m2.7 at onset of HD and reached 36.2±2.6 g/m2.7 (mean±SEM, P<0.0001) at last follow up. Over the observation period, systolic (P<0.0001) and diastolic (P<0.0001) blood pressure (indexed for height, gender, and age) decreased and hemoglobin (+2.8 g/dL; P<0.0001) increased compared to initial values. Only BP as well as plasma protein level at onset of HD session correlated with LVM in multiple correlation analysis. In conclusion, increased LVM is a common feature in pediatric patients with ESRD. Normalization of BP and reduction of the extracellular volume (represented by plasma protein at onset of HD session) are key points in reducing LVH during HD in children.
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Metadata
Title
Reduction of left ventricular hypertrophy in children undergoing hemodialysis
Authors
Tim Ulinski
Julie Genty
Christine Viau
Isabelle Tillous-Borde
Georges Deschênes
Publication date
01-08-2006
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 8/2006
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-006-0122-6

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