Skip to main content
Top
Published in: PharmacoEconomics 1/2007

01-01-2007 | Review Article

Reducing the Societal Burden of Depression

A Review of Economic Costs, Quality of Care and Effects of Treatment

Authors: Dr Julie M. Donohue, Harold Alan Pincus

Published in: PharmacoEconomics | Issue 1/2007

Login to get access

Abstract

Depression is a highly prevalent condition that results in substantial functional impairment. Advocates have attempted in recent years to make the ‘business case’ for investing in quality improvement efforts in depression care, particularly in primary care settings. The business case suggests that the costs of depression treatment may be offset by gains in worker productivity and/or reductions in other healthcare spending. In this paper, we review the evidence in support of this argument for improving the quality of depression treatment.
We examined the impact of depression on two of the primary drivers of the societal burden of depression: healthcare utilisation and worker productivity. Depression leads to higher healthcare utilisation and spending, most of which is not the result of depression treatment costs. Depression is also a leading cause of absenteeism and reduced productivity at work. It is clear that the economic burden of depression is substantial; however, critical gaps in the literature remain and need to be addressed. For instance, we do not know the economic burden of untreated and/or inappropriately treated versus appropriately treated depression.
There remain considerable problems with access to and quality of depression treatment. Progress has been made in terms of access to care, but quality of care is seldom consistent with national treatment guidelines. A wide range of effective treatments and care programmes for depression are available, yet rigorously tested clinical models to improve depression care have not been widely adopted by healthcare systems. Barriers to improving depression care exist at the patient, healthcare provider, practice, plan and purchaser levels, and may be both economic and non-economic.
Studies evaluating interventions to improve the quality of depression treatment have found that the cost per QALY associated with improved depression care ranges from a low of $US2519 to a high of $US49 500. We conclude from our review of the literature that effective treatment of depression is cost effective, but that evidence of a medical or productivity cost offset for depression treatment remains equivocal, and this points to the need for further research in this area.
Footnotes
1
Authors’ calculation from average hours per worker per week of absenteeism reported in Stewart et al.[56] multiplied by 48 and divided by 8 hours to reach number of days.
 
Literature
1.
go back to reference Murray CJL, Lopez AD. The global burden of disease: a comprehensive assessment of mortality and morbidity from diseases, injury and risk factors in 1990 and projected to 2020. Cambridge (MA): Harvard University Press, 1996 Murray CJL, Lopez AD. The global burden of disease: a comprehensive assessment of mortality and morbidity from diseases, injury and risk factors in 1990 and projected to 2020. Cambridge (MA): Harvard University Press, 1996
2.
go back to reference Ustun TB, Ayuso-Mateos JL, Chatterji S, et al. Global burden of depressive disorders in the year 2000. Br J Psychiatry 2004; 184: 386–392PubMedCrossRef Ustun TB, Ayuso-Mateos JL, Chatterji S, et al. Global burden of depressive disorders in the year 2000. Br J Psychiatry 2004; 184: 386–392PubMedCrossRef
3.
go back to reference Greenberg PE, Kessler RC, Birnbaum HG, et al. The economic burden of depression in the United States: how did it change between 1990 and 2000? J Clin Psych 2003; 64 (12): 1465–1473CrossRef Greenberg PE, Kessler RC, Birnbaum HG, et al. The economic burden of depression in the United States: how did it change between 1990 and 2000? J Clin Psych 2003; 64 (12): 1465–1473CrossRef
4.
go back to reference Panzarino Jr PJ. The costs of depression: direct and indirect; treatment versus nontreatment. J Clin Psych 1998; 59 Suppl. 20: 11–14 Panzarino Jr PJ. The costs of depression: direct and indirect; treatment versus nontreatment. J Clin Psych 1998; 59 Suppl. 20: 11–14
5.
go back to reference Pincus HA, Pettit AR. The societal costs of chronic major depression. J Clin Psych 2001; 62 Suppl. 6: 5–9 Pincus HA, Pettit AR. The societal costs of chronic major depression. J Clin Psych 2001; 62 Suppl. 6: 5–9
6.
go back to reference Thompson D Richardson E. Current issues in the economics of depression management. Curr Psychiatry Rep 1999; 1: 125–134PubMedCrossRef Thompson D Richardson E. Current issues in the economics of depression management. Curr Psychiatry Rep 1999; 1: 125–134PubMedCrossRef
7.
go back to reference Schulberg HC, Katon W, Simon GE, et al. Treating major depression in primary care: an update of the Agency for Health Care Policy and Research Practice Guidelines. Arch Gen Psych 1998; 55: 1121–1127CrossRef Schulberg HC, Katon W, Simon GE, et al. Treating major depression in primary care: an update of the Agency for Health Care Policy and Research Practice Guidelines. Arch Gen Psych 1998; 55: 1121–1127CrossRef
8.
go back to reference Hirschfield RMA, Keller MB, Panico S, et al. The National Depressive and Manic-Depressive Association consensus statement on the undertreatment of depression. JAMA 1997; 277 (4): 333–340CrossRef Hirschfield RMA, Keller MB, Panico S, et al. The National Depressive and Manic-Depressive Association consensus statement on the undertreatment of depression. JAMA 1997; 277 (4): 333–340CrossRef
9.
go back to reference US Department of Health and Human Services. Mental health: a report of the Surgeon General. Rockville (MD): US Department of Health and Human Services, 1999 US Department of Health and Human Services. Mental health: a report of the Surgeon General. Rockville (MD): US Department of Health and Human Services, 1999
10.
go back to reference Regier DA, Hirschfeld RMA, Goodwin FK, et al. The NIMH depression awareness, recognition, and treatment programs: structure, aims, and scientific basis. Am J Psychiatry 1998; 145 (11): 1351–1357 Regier DA, Hirschfeld RMA, Goodwin FK, et al. The NIMH depression awareness, recognition, and treatment programs: structure, aims, and scientific basis. Am J Psychiatry 1998; 145 (11): 1351–1357
11.
go back to reference Pincus HA, Hough L, Knox-Houtsinger J, et al. Emerging models of depression care: multi-level (‘6P’) strategies. Int J Methods Psychiatr Res 2003; 12 (1): 54–63PubMedCrossRef Pincus HA, Hough L, Knox-Houtsinger J, et al. Emerging models of depression care: multi-level (‘6P’) strategies. Int J Methods Psychiatr Res 2003; 12 (1): 54–63PubMedCrossRef
12.
go back to reference Young AS, Klap R, Sherbourne CD, et al. The quality of care for depressive and anxiety disorders in the United States. Arch Gen Psych 2001; 58 (1): 55–61CrossRef Young AS, Klap R, Sherbourne CD, et al. The quality of care for depressive and anxiety disorders in the United States. Arch Gen Psych 2001; 58 (1): 55–61CrossRef
13.
go back to reference Meredith LA. Depression:20 years of progress. Med Care 2004; 42 (6): 499–501 Meredith LA. Depression:20 years of progress. Med Care 2004; 42 (6): 499–501
14.
go back to reference Pincus HA. The future of behavioral health and primary care: drowning in the mainstream or left on the bank? Psychosomatics 2003; 44 (1): 1–11PubMedCrossRef Pincus HA. The future of behavioral health and primary care: drowning in the mainstream or left on the bank? Psychosomatics 2003; 44 (1): 1–11PubMedCrossRef
15.
go back to reference Katon W, Robinson P, Von Korff M, et al. A multifaceted intervention to improve treatment of depression in primary care. Arch Gen Psych 1996; 53 (10): 924–932CrossRef Katon W, Robinson P, Von Korff M, et al. A multifaceted intervention to improve treatment of depression in primary care. Arch Gen Psych 1996; 53 (10): 924–932CrossRef
16.
go back to reference Katon W, Rutter C, Ludman EJ, et al. A randomized trial of relapse prevention of depression in primary care. Arch Gen Psych 2001; 58: 241–247CrossRef Katon W, Rutter C, Ludman EJ, et al. A randomized trial of relapse prevention of depression in primary care. Arch Gen Psych 2001; 58: 241–247CrossRef
17.
go back to reference Katon W, Von Korff M, Lin E, et al. Collaborative management to achieve treatment guidelines: impact on depression in primary care. JAMA 1995; 273 (13): 1026–1031PubMedCrossRef Katon W, Von Korff M, Lin E, et al. Collaborative management to achieve treatment guidelines: impact on depression in primary care. JAMA 1995; 273 (13): 1026–1031PubMedCrossRef
18.
go back to reference Katzelnick DJ, Simon GE, Pearson SD, et al. Randomized trial of a depression management program in high utilizers of medical care. Arch Fam Med 2000; 9: 345–351PubMedCrossRef Katzelnick DJ, Simon GE, Pearson SD, et al. Randomized trial of a depression management program in high utilizers of medical care. Arch Fam Med 2000; 9: 345–351PubMedCrossRef
19.
go back to reference Rost K, Nutting PA, Smith J, et al. Designing and implementing a primary care intervention trial to improve the quality and outcome of care for major depression. Gen Hosp Psych 2000; 22: 66–77CrossRef Rost K, Nutting PA, Smith J, et al. Designing and implementing a primary care intervention trial to improve the quality and outcome of care for major depression. Gen Hosp Psych 2000; 22: 66–77CrossRef
20.
go back to reference Schulberg HC, Block MR, Madonia MJ, et al. Treating major depression in primary care practice: eight-month clinical outcomes. Arch Gen Psych 1996; 53 (10): 913–919CrossRef Schulberg HC, Block MR, Madonia MJ, et al. Treating major depression in primary care practice: eight-month clinical outcomes. Arch Gen Psych 1996; 53 (10): 913–919CrossRef
21.
go back to reference Sherbourne CD, Wells KB, Duan N, et al. Long-term effectiveness of disseminating quality improvement for depression in primary care. Arch Gen Psych 2001; 58: 696–703CrossRef Sherbourne CD, Wells KB, Duan N, et al. Long-term effectiveness of disseminating quality improvement for depression in primary care. Arch Gen Psych 2001; 58: 696–703CrossRef
22.
go back to reference Unutzer J, Rubenstein L, Katon WJ, et al. Two-year effects of quality improvement programs on medication management for depression. Arch Gen Psych 2001; 58 (10): 935–942CrossRef Unutzer J, Rubenstein L, Katon WJ, et al. Two-year effects of quality improvement programs on medication management for depression. Arch Gen Psych 2001; 58 (10): 935–942CrossRef
23.
go back to reference Wells KB, Sherbourne C, Shoenbaum M, et al. Impact of disseminating quality improvement programs for depression in managed primary care: a randomized controlled trial. JAMA 2000; 283 (2): 212–220PubMedCrossRef Wells KB, Sherbourne C, Shoenbaum M, et al. Impact of disseminating quality improvement programs for depression in managed primary care: a randomized controlled trial. JAMA 2000; 283 (2): 212–220PubMedCrossRef
24.
go back to reference Langlieb AM, Kahn JP. How much does quality mental health care profit employers? J Occup Environ Med 2005; 47 (11): 1099–1109PubMedCrossRef Langlieb AM, Kahn JP. How much does quality mental health care profit employers? J Occup Environ Med 2005; 47 (11): 1099–1109PubMedCrossRef
25.
go back to reference Goetzel RZ, Ozminkowski RJ, Sederer LI, et al. The business case for quality mental health services: why employers should care about the mental health and well-being of their employees. J Occup Environ Med 2002; 44 (4): 320–330PubMedCrossRef Goetzel RZ, Ozminkowski RJ, Sederer LI, et al. The business case for quality mental health services: why employers should care about the mental health and well-being of their employees. J Occup Environ Med 2002; 44 (4): 320–330PubMedCrossRef
26.
go back to reference Kessler RC, Chiu WT, Demler O, et al. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psych 2005; 62: 617–627CrossRef Kessler RC, Chiu WT, Demler O, et al. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psych 2005; 62: 617–627CrossRef
27.
go back to reference Kessler RC, Berglund P, Demler O, et al. The epidemiology of major depressive disorder:results from the National Comorbidity Survey Replication(NCS-R). JAMA 2003; 289 (23): 3095–3105PubMedCrossRef Kessler RC, Berglund P, Demler O, et al. The epidemiology of major depressive disorder:results from the National Comorbidity Survey Replication(NCS-R). JAMA 2003; 289 (23): 3095–3105PubMedCrossRef
28.
go back to reference Andrade L, Caraveo-Anduaga JJ, Berglund P, et al. The epidemiology of major depressive episodes: results from the International Consortium of Psychiatric Epidemiology (ICPE) survey. Int J Methods Psychiatr Res 2003; 12 (1): 3–21PubMedCrossRef Andrade L, Caraveo-Anduaga JJ, Berglund P, et al. The epidemiology of major depressive episodes: results from the International Consortium of Psychiatric Epidemiology (ICPE) survey. Int J Methods Psychiatr Res 2003; 12 (1): 3–21PubMedCrossRef
29.
go back to reference Goldney R, Hawthorne G, Fisher L, et al. Is the Australian National Survey of Mental Health and Wellbeing a reliable guide for health planners? A methodological note on the prevalence of depression. Aust N Z J Psychiatry 2004; (38): 635–638CrossRef Goldney R, Hawthorne G, Fisher L, et al. Is the Australian National Survey of Mental Health and Wellbeing a reliable guide for health planners? A methodological note on the prevalence of depression. Aust N Z J Psychiatry 2004; (38): 635–638CrossRef
30.
go back to reference Wittchen HU, Jacobi F. Size and burden of mental disorders in Europe: a critical review and appraisal of 27 studies. Eur Neuropsychopharmacol 2005; 15: 357–376PubMedCrossRef Wittchen HU, Jacobi F. Size and burden of mental disorders in Europe: a critical review and appraisal of 27 studies. Eur Neuropsychopharmacol 2005; 15: 357–376PubMedCrossRef
31.
go back to reference Wells KB, Stewart A, Hays RD, et al. The functioning and well-being of depressed patients. JAMA 1989; 262: 914–919PubMedCrossRef Wells KB, Stewart A, Hays RD, et al. The functioning and well-being of depressed patients. JAMA 1989; 262: 914–919PubMedCrossRef
32.
go back to reference Katon WJ, Shoenbaum M, Fan MY, et al. Cost-effectiveness of improving primary care treatment of late-life depression. Arch Gen Psych 2005; 62 (12): 1313–1320CrossRef Katon WJ, Shoenbaum M, Fan MY, et al. Cost-effectiveness of improving primary care treatment of late-life depression. Arch Gen Psych 2005; 62 (12): 1313–1320CrossRef
33.
go back to reference Rost K, Pyne JM, Dickinson LM, et al. Cost-effectiveness of enhancing primary care depression management on an ongoing basis. Ann Fam Med 2005; 3: 7–14PubMedCrossRef Rost K, Pyne JM, Dickinson LM, et al. Cost-effectiveness of enhancing primary care depression management on an ongoing basis. Ann Fam Med 2005; 3: 7–14PubMedCrossRef
34.
go back to reference Pyne JM, Rost KM, Zhang M, et al. Cost-effectiveness of a primary care depression intervention. J Gen Int Med 2003; 18 (6): 432–441CrossRef Pyne JM, Rost KM, Zhang M, et al. Cost-effectiveness of a primary care depression intervention. J Gen Int Med 2003; 18 (6): 432–441CrossRef
35.
go back to reference Simon GE, Von Korff M, Ludman EJ, et al. Cost-effectiveness of a program to prevent depression relapse in primary care. Med Care 2002; 40 (10): 941–950PubMedCrossRef Simon GE, Von Korff M, Ludman EJ, et al. Cost-effectiveness of a program to prevent depression relapse in primary care. Med Care 2002; 40 (10): 941–950PubMedCrossRef
36.
go back to reference Simon GE, Manning WG, Katzelnick DJ, et al. Cost-effectiveness of systematic depression treatment for high utilizers of general medical Care. Arch Gen Psych 2001; 58: 181–187CrossRef Simon GE, Manning WG, Katzelnick DJ, et al. Cost-effectiveness of systematic depression treatment for high utilizers of general medical Care. Arch Gen Psych 2001; 58: 181–187CrossRef
37.
go back to reference Schoenbaum M, Unutzer J, Sherbourne C, et al. Cost-effectiveness of practice-initiated quality improvement for depression: results of a randomized controlled trial. JAMA 2001; 286 (11): 1325–1330PubMedCrossRef Schoenbaum M, Unutzer J, Sherbourne C, et al. Cost-effectiveness of practice-initiated quality improvement for depression: results of a randomized controlled trial. JAMA 2001; 286 (11): 1325–1330PubMedCrossRef
38.
go back to reference Lave JR, Frank RG, Schulberg HC, et al. Cost-effectiveness of treatments for major depression in primary care practice. Arch Gen Psych 1998; 55: 645–651CrossRef Lave JR, Frank RG, Schulberg HC, et al. Cost-effectiveness of treatments for major depression in primary care practice. Arch Gen Psych 1998; 55: 645–651CrossRef
39.
go back to reference Von Korff M, Katon W, Bush T, et al. Treatment costs, cost offset, and cost-effectiveness of collaborative management of depression. Psychosom Med 1998; 60 (2): 143–149 Von Korff M, Katon W, Bush T, et al. Treatment costs, cost offset, and cost-effectiveness of collaborative management of depression. Psychosom Med 1998; 60 (2): 143–149
40.
go back to reference Greenberg P, Corey-Lisle PK, Birnbaum H, et al. Economic implications of treatment-resistant depression among employees. Pharmacoeconomics 2004; 22 (6): 363–373PubMedCrossRef Greenberg P, Corey-Lisle PK, Birnbaum H, et al. Economic implications of treatment-resistant depression among employees. Pharmacoeconomics 2004; 22 (6): 363–373PubMedCrossRef
41.
go back to reference Greenberg PE, Stiglin LE, Finkelstein SN, et al. The economic burden of depression in 1990. J Clin Psych 1993; 54 (11): 405–418 Greenberg PE, Stiglin LE, Finkelstein SN, et al. The economic burden of depression in 1990. J Clin Psych 1993; 54 (11): 405–418
42.
go back to reference Stoudemire A, Frank R, Hedemark N, et al. The economic burden of depression. Gen Hosp Psych 1986; 8: 387–394CrossRef Stoudemire A, Frank R, Hedemark N, et al. The economic burden of depression. Gen Hosp Psych 1986; 8: 387–394CrossRef
43.
go back to reference Rice DP, Miller LS. The economic burden of affective disorders. Br J Psychiatry 1995; 166 Suppl. 27: 34–42 Rice DP, Miller LS. The economic burden of affective disorders. Br J Psychiatry 1995; 166 Suppl. 27: 34–42
44.
go back to reference Druss B, Rosenheck R, Sledge W. Health and disability costs of depressive illness in a major US corporation. Am J Psych 2000; 157 (8): 1274–1278CrossRef Druss B, Rosenheck R, Sledge W. Health and disability costs of depressive illness in a major US corporation. Am J Psych 2000; 157 (8): 1274–1278CrossRef
45.
go back to reference Russell JM, Hawkins K, Ozminkowski RJ, et al. The cost consequences of treatment-resistant depression. J Clin Psych 2004; (65): 341–347CrossRef Russell JM, Hawkins K, Ozminkowski RJ, et al. The cost consequences of treatment-resistant depression. J Clin Psych 2004; (65): 341–347CrossRef
46.
go back to reference Croghan T, Obenchain RL, Crown WE. What does treatment of depression really cost? Health Aff 1998; 17: 198–208CrossRef Croghan T, Obenchain RL, Crown WE. What does treatment of depression really cost? Health Aff 1998; 17: 198–208CrossRef
47.
go back to reference Simon GE, Von Korff M, Barlow W. Health care costs of primary care patients with recognized depression. Arch Gen Psych 1995; 52: 850–856CrossRef Simon GE, Von Korff M, Barlow W. Health care costs of primary care patients with recognized depression. Arch Gen Psych 1995; 52: 850–856CrossRef
48.
go back to reference Simon GE, Von Korff M, Barlow W. Health care costs associated with depressive and anxiety disorders in primary care. Am J Psychiatry 1995; 152: 352–357PubMed Simon GE, Von Korff M, Barlow W. Health care costs associated with depressive and anxiety disorders in primary care. Am J Psychiatry 1995; 152: 352–357PubMed
49.
go back to reference Unutzer J, Patrick DL, Simon G, et al. Depressive symptoms and the cost of health services in HMO patients aged 65 years and older: a 4 year prospective study. JAMA 1997; 277: 1618–1623PubMedCrossRef Unutzer J, Patrick DL, Simon G, et al. Depressive symptoms and the cost of health services in HMO patients aged 65 years and older: a 4 year prospective study. JAMA 1997; 277: 1618–1623PubMedCrossRef
50.
go back to reference Katon WJ, Lin E, Russo J, et al. Increased medical costs of a population-based sample of depressed elderly patients. Arch Gen Psych 2003; 60: 897–903CrossRef Katon WJ, Lin E, Russo J, et al. Increased medical costs of a population-based sample of depressed elderly patients. Arch Gen Psych 2003; 60: 897–903CrossRef
51.
go back to reference Goetzel RZ, Anderson DR, Whitmer W, et al. The relationship between modifiable health risks and health care expenditures: an analysis of the multi-employer HERO health risk and cost database. J Occup Environ Med 1998; 40 (10): 843–854PubMedCrossRef Goetzel RZ, Anderson DR, Whitmer W, et al. The relationship between modifiable health risks and health care expenditures: an analysis of the multi-employer HERO health risk and cost database. J Occup Environ Med 1998; 40 (10): 843–854PubMedCrossRef
52.
go back to reference Henk HJ, Katzelnick DJ, Kobak KA, et al. Medical costs attributed to depression among patients with a history of high medical expenses in a health maintenance organization. Arch Gen Psych 1996; 53 (10): 899–904CrossRef Henk HJ, Katzelnick DJ, Kobak KA, et al. Medical costs attributed to depression among patients with a history of high medical expenses in a health maintenance organization. Arch Gen Psych 1996; 53 (10): 899–904CrossRef
53.
go back to reference Emptage NP, Sturm R, Robinson RL. Depression and comorbid pain as predictors of disability, employment, insurance status, and health care costs. Psychiatr Serv 2005; 56 (4): 468–474PubMedCrossRef Emptage NP, Sturm R, Robinson RL. Depression and comorbid pain as predictors of disability, employment, insurance status, and health care costs. Psychiatr Serv 2005; 56 (4): 468–474PubMedCrossRef
54.
go back to reference Shvartzman P, Weiner Z, Vardy D, et al. Health services utilization by depressive patients identified by the MINI questionnaire in a primary care setting. Scand J Prim Health Care 2005; 23: 18–25PubMedCrossRef Shvartzman P, Weiner Z, Vardy D, et al. Health services utilization by depressive patients identified by the MINI questionnaire in a primary care setting. Scand J Prim Health Care 2005; 23: 18–25PubMedCrossRef
55.
go back to reference Berndt ER, Koran LM, Finkelstein SN, et al. Lost human capital from early-onset chronic depression. Am J Psychiatry 2000; 157 (6): 940–947PubMedCrossRef Berndt ER, Koran LM, Finkelstein SN, et al. Lost human capital from early-onset chronic depression. Am J Psychiatry 2000; 157 (6): 940–947PubMedCrossRef
56.
go back to reference Stewart WF, Ricci JA, Chee E, et al. Cost of lost productive work time among US workers with depression. JAMA 2003; 289: 3135–3144PubMedCrossRef Stewart WF, Ricci JA, Chee E, et al. Cost of lost productive work time among US workers with depression. JAMA 2003; 289: 3135–3144PubMedCrossRef
57.
go back to reference Rost K, Smith JL, Dickinson M. The effect of improving primary care depression management on employee absenteeism and productivity: a randomized trial. Med Care Dec 2004; 42 (12): 1202–1210CrossRef Rost K, Smith JL, Dickinson M. The effect of improving primary care depression management on employee absenteeism and productivity: a randomized trial. Med Care Dec 2004; 42 (12): 1202–1210CrossRef
58.
go back to reference Zhang M, Rost KM, Fortney JC, et al. A community study of depression treatment and employment earning. Psychiatr Serv 1999; 50 (9): 1209–1213PubMed Zhang M, Rost KM, Fortney JC, et al. A community study of depression treatment and employment earning. Psychiatr Serv 1999; 50 (9): 1209–1213PubMed
59.
go back to reference Zhang M, Rost KM, Fortney JC. Earnings changes for depressed individuals treated by mental health specialists. Am J Psychiatry 1999; 156 (1): 108–114PubMed Zhang M, Rost KM, Fortney JC. Earnings changes for depressed individuals treated by mental health specialists. Am J Psychiatry 1999; 156 (1): 108–114PubMed
60.
go back to reference Kessler RC, Barner C, Birnbaum HG, et al. Depression in the workplace: effects on short-term disability. Health Aff 1999; 18 (5): 163–171CrossRef Kessler RC, Barner C, Birnbaum HG, et al. Depression in the workplace: effects on short-term disability. Health Aff 1999; 18 (5): 163–171CrossRef
61.
go back to reference Leon AC, Walkup JT, Porntera L. Assessment and treatment of depression in disability claimants: a cost-benefit simulation. J Nerv Ment Dis 2002; 190 (1): 3–9PubMedCrossRef Leon AC, Walkup JT, Porntera L. Assessment and treatment of depression in disability claimants: a cost-benefit simulation. J Nerv Ment Dis 2002; 190 (1): 3–9PubMedCrossRef
62.
go back to reference Collins JJ, Baase CM, Sharda CE, et al. The assessment of chronic health conditions on work performance, absence, and total economic impact for employers. J Occup Environ Med 2005; 47 (6): 547–557PubMedCrossRef Collins JJ, Baase CM, Sharda CE, et al. The assessment of chronic health conditions on work performance, absence, and total economic impact for employers. J Occup Environ Med 2005; 47 (6): 547–557PubMedCrossRef
63.
go back to reference Himmelhoch S, Weller WE, Wu AW, et al. Chronic medical illness, depression and use of acute medical services among Medicare beneficiaries. Med Care 2004; 42 (6): 512–521CrossRef Himmelhoch S, Weller WE, Wu AW, et al. Chronic medical illness, depression and use of acute medical services among Medicare beneficiaries. Med Care 2004; 42 (6): 512–521CrossRef
64.
go back to reference Katon WJ, Ciechanowski P. Impact of major depression on chronic medical illness. J Psychosom Res 2002; 53: 859–863PubMedCrossRef Katon WJ, Ciechanowski P. Impact of major depression on chronic medical illness. J Psychosom Res 2002; 53: 859–863PubMedCrossRef
65.
go back to reference Pignone MP, Gaynes BN, Rushton JL, et al. Screening for depression in adults: a summary of the evidence for the Preventive Services Task Force. Ann Intern Med 2002; 136: 765–776PubMed Pignone MP, Gaynes BN, Rushton JL, et al. Screening for depression in adults: a summary of the evidence for the Preventive Services Task Force. Ann Intern Med 2002; 136: 765–776PubMed
66.
go back to reference Whyte EM, Mulsant BH. Post stroke depression: epidemiology, pathophysiology, and biological treatment. Biol Psychiatry 2002; 52 (3): 253–264PubMedCrossRef Whyte EM, Mulsant BH. Post stroke depression: epidemiology, pathophysiology, and biological treatment. Biol Psychiatry 2002; 52 (3): 253–264PubMedCrossRef
67.
go back to reference deGroot M, Anderson R, Freedland KE, et al. Association of depression and diabetes complications: a meta-analysis. Psychosom Med 2001; 63: 619–630 deGroot M, Anderson R, Freedland KE, et al. Association of depression and diabetes complications: a meta-analysis. Psychosom Med 2001; 63: 619–630
68.
go back to reference DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Int Med 2000; 160 (14): 2101–2107CrossRef DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Int Med 2000; 160 (14): 2101–2107CrossRef
69.
go back to reference Katon WJ. Clinical and health services relationships between major depression, depressive symptoms, and general medical illness. Biol Psychiatry 2003; 54: 216–226PubMedCrossRef Katon WJ. Clinical and health services relationships between major depression, depressive symptoms, and general medical illness. Biol Psychiatry 2003; 54: 216–226PubMedCrossRef
70.
go back to reference Ciechanowski PS, Katon WJ, Russo JE. Depression and diabetes. Arch Intern Med 2000; 160: 3278–3285PubMedCrossRef Ciechanowski PS, Katon WJ, Russo JE. Depression and diabetes. Arch Intern Med 2000; 160: 3278–3285PubMedCrossRef
71.
go back to reference Lin E, Katon W, Von Korff M, et al. Relationship of depression and diabetes self-care, medication adherence, and preventive care. Diabetes Care 2004; 27 (9): 2154–2160PubMedCrossRef Lin E, Katon W, Von Korff M, et al. Relationship of depression and diabetes self-care, medication adherence, and preventive care. Diabetes Care 2004; 27 (9): 2154–2160PubMedCrossRef
72.
go back to reference Kessler RC, Foster CL, Saunders WB, et al. Social consequences of psychiatric disorders: I. Educational attainment. Am J Psych 1995; 152 (7): 1026–1032 Kessler RC, Foster CL, Saunders WB, et al. Social consequences of psychiatric disorders: I. Educational attainment. Am J Psych 1995; 152 (7): 1026–1032
73.
go back to reference Wells KB, Stewart A, Hays RD, et al. The functioning and well-being of depressed patients: results from the Medical Outcomes Study. JAMA 18 Aug 1989; 262 (7): 914–919CrossRef Wells KB, Stewart A, Hays RD, et al. The functioning and well-being of depressed patients: results from the Medical Outcomes Study. JAMA 18 Aug 1989; 262 (7): 914–919CrossRef
74.
go back to reference Simon GE, Barber C, Birnbaum HG, et al. Depression and work productivity: the comparative costs of treatment versus non-treatment. J Occup Environ Med 2001; 43 (1): 2–9PubMedCrossRef Simon GE, Barber C, Birnbaum HG, et al. Depression and work productivity: the comparative costs of treatment versus non-treatment. J Occup Environ Med 2001; 43 (1): 2–9PubMedCrossRef
75.
go back to reference Ettner SL, Frank RG, Kessler RC. The impact of psychiatric disorders on labor market outcomes. Ind Labor Relat Rev 1997; 54: 64–81CrossRef Ettner SL, Frank RG, Kessler RC. The impact of psychiatric disorders on labor market outcomes. Ind Labor Relat Rev 1997; 54: 64–81CrossRef
76.
go back to reference Kessler RC, Greenberg PE, Mickelson KD, et al. The effects of chronic medical conditions on work loss and work cutback. J Occup Environ Med 2001; 43: 218–225PubMedCrossRef Kessler RC, Greenberg PE, Mickelson KD, et al. The effects of chronic medical conditions on work loss and work cutback. J Occup Environ Med 2001; 43: 218–225PubMedCrossRef
77.
go back to reference Ormel J, Von Korff M, Ustun TB, et al. Common mental disorders and disability across cultures: results from the WHO collaborative study on psychological problems in general health care. JAMA 1994; 272: 1741–1748PubMedCrossRef Ormel J, Von Korff M, Ustun TB, et al. Common mental disorders and disability across cultures: results from the WHO collaborative study on psychological problems in general health care. JAMA 1994; 272: 1741–1748PubMedCrossRef
78.
go back to reference Wang PS, Beck AL, Berglund P, et al. Effects of major depression on moment-in-time work performance. Am J Psych 2004; 161: 1885–18891CrossRef Wang PS, Beck AL, Berglund P, et al. Effects of major depression on moment-in-time work performance. Am J Psych 2004; 161: 1885–18891CrossRef
79.
go back to reference Von Korff M, Katon W, Unutzer J, et al. Improving depression care: barriers, solutions, and research needs. J Fam Pract 2001; 50 (6): 529–530 Von Korff M, Katon W, Unutzer J, et al. Improving depression care: barriers, solutions, and research needs. J Fam Pract 2001; 50 (6): 529–530
80.
go back to reference Thomas CM, Morris S. Cost of depression among adults in England in 2000. Br J Psychiatry 2003; 183: 514–519PubMedCrossRef Thomas CM, Morris S. Cost of depression among adults in England in 2000. Br J Psychiatry 2003; 183: 514–519PubMedCrossRef
81.
go back to reference Hu T. The economic burden of depression and reimbursement policy in the Asia Pacific region. Australas Psychiatry 2004; 12 Suppl. 1: S11–S15PubMedCrossRef Hu T. The economic burden of depression and reimbursement policy in the Asia Pacific region. Australas Psychiatry 2004; 12 Suppl. 1: S11–S15PubMedCrossRef
82.
go back to reference Wulsin L, Vaillant G, Wells KB. A systematic review of the mortality of depression. Psychosom Med 1999; 61: 6–17PubMed Wulsin L, Vaillant G, Wells KB. A systematic review of the mortality of depression. Psychosom Med 1999; 61: 6–17PubMed
83.
go back to reference Wang PS, Simon G, Kessler RC. The economic burden of depression and the cost-effectiveness of treatment. Int J Methods Psychiatr Res 2003; 12 (1): 22–23PubMedCrossRef Wang PS, Simon G, Kessler RC. The economic burden of depression and the cost-effectiveness of treatment. Int J Methods Psychiatr Res 2003; 12 (1): 22–23PubMedCrossRef
84.
go back to reference Peele PB, Tollerud DJ. Depression and occupational injury: results of a pilot investigation. J Occup Environ Med 2005; 47: 424–427PubMedCrossRef Peele PB, Tollerud DJ. Depression and occupational injury: results of a pilot investigation. J Occup Environ Med 2005; 47: 424–427PubMedCrossRef
85.
go back to reference Heru AM, Ryan CE. Burden, reward and family functioning of caregivers for relatives with mood disorders: 1-year follow-up. J Affect Disord 2004; 83: 221–225PubMedCrossRef Heru AM, Ryan CE. Burden, reward and family functioning of caregivers for relatives with mood disorders: 1-year follow-up. J Affect Disord 2004; 83: 221–225PubMedCrossRef
86.
go back to reference DeLeire T, Manning W. Labor market costs of illness: prevalence matters. Health Econ 2004; 13: 239–250PubMedCrossRef DeLeire T, Manning W. Labor market costs of illness: prevalence matters. Health Econ 2004; 13: 239–250PubMedCrossRef
87.
go back to reference Birnbaum HG, Leong SA, Greenberg PE. The economics of women and depression: an employer’s perspective. J Affect Disord 2003; 74: 15–22PubMedCrossRef Birnbaum HG, Leong SA, Greenberg PE. The economics of women and depression: an employer’s perspective. J Affect Disord 2003; 74: 15–22PubMedCrossRef
88.
go back to reference Kessler RC, Frank RG. The impact of psychiatric disorders on work loss days. Psychol Med 1997; 27: 218–225 Kessler RC, Frank RG. The impact of psychiatric disorders on work loss days. Psychol Med 1997; 27: 218–225
89.
go back to reference Pincus HA, Tanielian TL, Marcus SC, et al. Prescribing trends in psychotropic medications: primary care, psychiatry, and other medical specialties. JAMA 1998; 279: 526–531PubMedCrossRef Pincus HA, Tanielian TL, Marcus SC, et al. Prescribing trends in psychotropic medications: primary care, psychiatry, and other medical specialties. JAMA 1998; 279: 526–531PubMedCrossRef
90.
go back to reference Olfson M, Marcus S, Druss B, et al. National trends in the outpatient treatment of depression. JAMA 2002; 287: 203–209PubMedCrossRef Olfson M, Marcus S, Druss B, et al. National trends in the outpatient treatment of depression. JAMA 2002; 287: 203–209PubMedCrossRef
91.
go back to reference Wittchen HU, Pittrow D. Prevalence, recognition and management of depression in primary care in Germany: the Depression 2000 study. Hum Psychopharmacol 2002; (17): S1–S16PubMedCrossRef Wittchen HU, Pittrow D. Prevalence, recognition and management of depression in primary care in Germany: the Depression 2000 study. Hum Psychopharmacol 2002; (17): S1–S16PubMedCrossRef
92.
go back to reference ESEMeD/MHEDEA 2000 investigators. Use of mental health services in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatr Scand 2004; 109 Suppl. 420: 47–54CrossRef ESEMeD/MHEDEA 2000 investigators. Use of mental health services in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatr Scand 2004; 109 Suppl. 420: 47–54CrossRef
93.
go back to reference Wang PS, Lane M, Olfson M, et al. Twelve-month use of mental health services in the US. Arch Gen Psych 2005; 62: 629–640CrossRef Wang PS, Lane M, Olfson M, et al. Twelve-month use of mental health services in the US. Arch Gen Psych 2005; 62: 629–640CrossRef
94.
go back to reference Gandjour A, Telzerow A, Lauterbach W. Costs and quality in the treatment of acute depression in primary care: a comparison between England, Germany and Switzerland. Int Clin Psychopharmacol 2004; 19 (4): 201–208PubMedCrossRef Gandjour A, Telzerow A, Lauterbach W. Costs and quality in the treatment of acute depression in primary care: a comparison between England, Germany and Switzerland. Int Clin Psychopharmacol 2004; 19 (4): 201–208PubMedCrossRef
95.
go back to reference Horvitz-Lennon M, Normand S, Frank RG, et al. Usual care for major depression in the 1990s: characteristics and expert-estimated outcomes. Am J Psychiatry 2003; 160: 720–726PubMedCrossRef Horvitz-Lennon M, Normand S, Frank RG, et al. Usual care for major depression in the 1990s: characteristics and expert-estimated outcomes. Am J Psychiatry 2003; 160: 720–726PubMedCrossRef
96.
go back to reference Gilbody S, Whitty P, Grimshaw J, et al. Educational and organizational interventions to improve the management of depression in primary care. JAMA 2003; 289: 3145–3151PubMedCrossRef Gilbody S, Whitty P, Grimshaw J, et al. Educational and organizational interventions to improve the management of depression in primary care. JAMA 2003; 289: 3145–3151PubMedCrossRef
97.
go back to reference Badamgarav E, Weingarten SR, Henning JM, et al. Effectiveness of disease management programs in depression: a systematic review. Am J Psychiatry 2003; 160 (12): 2080–2090PubMedCrossRef Badamgarav E, Weingarten SR, Henning JM, et al. Effectiveness of disease management programs in depression: a systematic review. Am J Psychiatry 2003; 160 (12): 2080–2090PubMedCrossRef
98.
go back to reference Wagner EH, Austin BT, Von Korff M. Organizing care for patients with chronic illness. Milbank Q 1996; 74: 511–544PubMedCrossRef Wagner EH, Austin BT, Von Korff M. Organizing care for patients with chronic illness. Milbank Q 1996; 74: 511–544PubMedCrossRef
99.
go back to reference Callahan CM, Kroenke K, Counsell SR, et al. Treatment of depression improves physical functioning in older adults. J Am Geriatr Soc 2005; 53: 367–373PubMedCrossRef Callahan CM, Kroenke K, Counsell SR, et al. Treatment of depression improves physical functioning in older adults. J Am Geriatr Soc 2005; 53: 367–373PubMedCrossRef
100.
go back to reference Williams Jr JW, Katon W, Lin EHB, et al. The effectiveness of depression care management on diabetes-related outcomes in older patients. Ann Int Med 2004; 140 (12): 1015–1024PubMed Williams Jr JW, Katon W, Lin EHB, et al. The effectiveness of depression care management on diabetes-related outcomes in older patients. Ann Int Med 2004; 140 (12): 1015–1024PubMed
101.
go back to reference Lin EHB, Katon W, Von Korff M, et al. Effect of improving depression care on pain and functional outcomes among older adults with arthritis. JAMA 2003; 290 (18): 2428–2434PubMedCrossRef Lin EHB, Katon W, Von Korff M, et al. Effect of improving depression care on pain and functional outcomes among older adults with arthritis. JAMA 2003; 290 (18): 2428–2434PubMedCrossRef
102.
go back to reference Writing Committee. Effects of treating depression and low perceived social support on clinical events after myocardial infarction. JAMA 2003; 289: 3106–3116CrossRef Writing Committee. Effects of treating depression and low perceived social support on clinical events after myocardial infarction. JAMA 2003; 289: 3106–3116CrossRef
103.
go back to reference Barr Taylor C, Youngblood ME, Cagtellier D, et al., for the ENRICHED investigators. Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction. Arch Gen Psych 2005; 62: 792–798CrossRef Barr Taylor C, Youngblood ME, Cagtellier D, et al., for the ENRICHED investigators. Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction. Arch Gen Psych 2005; 62: 792–798CrossRef
104.
go back to reference Glassman A, O’Connor C, Califf R, et al. Sertraline treatment of major depression in patients with acute MI or unstable angina. JAMA 2002; 288 (6): 701–709PubMedCrossRef Glassman A, O’Connor C, Califf R, et al. Sertraline treatment of major depression in patients with acute MI or unstable angina. JAMA 2002; 288 (6): 701–709PubMedCrossRef
105.
go back to reference Mintz J, Mintz LI, Arruda MJ, et al. Treatments of depression and the functional capacity to work. Arch Gen Psych 1992; 49: 761–768CrossRef Mintz J, Mintz LI, Arruda MJ, et al. Treatments of depression and the functional capacity to work. Arch Gen Psych 1992; 49: 761–768CrossRef
106.
go back to reference Berndt ER, Finkelstein SN, Greenberg PE, et al. Workplace performance effects from chronic depression and its treatment. J Health Econ 1998; 17: 511–535PubMedCrossRef Berndt ER, Finkelstein SN, Greenberg PE, et al. Workplace performance effects from chronic depression and its treatment. J Health Econ 1998; 17: 511–535PubMedCrossRef
107.
go back to reference Simon GE, Revicki D, Heiligenstein J, et al. Recovery from depression, work productivity, and health care costs among primary care patients. Gen Hosp Psychiatry 2000; 22: 153–162PubMedCrossRef Simon GE, Revicki D, Heiligenstein J, et al. Recovery from depression, work productivity, and health care costs among primary care patients. Gen Hosp Psychiatry 2000; 22: 153–162PubMedCrossRef
108.
go back to reference McCulloch J, Ozminkowski RJ, Cuffel B, et al. Analysis of a managed psychiatric disability program. J Occup Environ Med 2001; 43 (2): 101–109PubMedCrossRef McCulloch J, Ozminkowski RJ, Cuffel B, et al. Analysis of a managed psychiatric disability program. J Occup Environ Med 2001; 43 (2): 101–109PubMedCrossRef
109.
go back to reference Soutere E, Lozet H, Cimarosti I. Predicting factors for absenteeism in patients with major depressive disorders. Eur J Epidemiol 1997; 13: 87–93CrossRef Soutere E, Lozet H, Cimarosti I. Predicting factors for absenteeism in patients with major depressive disorders. Eur J Epidemiol 1997; 13: 87–93CrossRef
110.
go back to reference Von Korff M, Ormel J, Katon W, et al. Disability and depression among high utilizers of health care. Arch Gen Psychiatry 1992; 49: 91–100CrossRef Von Korff M, Ormel J, Katon W, et al. Disability and depression among high utilizers of health care. Arch Gen Psychiatry 1992; 49: 91–100CrossRef
111.
go back to reference Simon GE, Chisholm D, Treglia M, et al. Course of depression, health services costs, and work productivity in an international primary care study. Gen Hosp Psychiatry 2002; 24: 328–335PubMedCrossRef Simon GE, Chisholm D, Treglia M, et al. Course of depression, health services costs, and work productivity in an international primary care study. Gen Hosp Psychiatry 2002; 24: 328–335PubMedCrossRef
112.
go back to reference Simon GE, Katon W, Rutter C, et al. Impact of improved depression treatment in primary care on daily functioning and disability. Psychological Med 1998; 28 (3): 693–701CrossRef Simon GE, Katon W, Rutter C, et al. Impact of improved depression treatment in primary care on daily functioning and disability. Psychological Med 1998; 28 (3): 693–701CrossRef
113.
go back to reference Von Korff M, Katon W, Rutter CM, et al. Effect on disability outcomes of a depression relapse prevention program. Psychosom Med 2003; 65: 938–943CrossRef Von Korff M, Katon W, Rutter CM, et al. Effect on disability outcomes of a depression relapse prevention program. Psychosom Med 2003; 65: 938–943CrossRef
114.
go back to reference Pincus HA, Pechura CM, Elinson L, et al. Depression in primary care: linking clinical and systems strategies. Gen Hosp Psychiatry 2001; 23: 311–318PubMedCrossRef Pincus HA, Pechura CM, Elinson L, et al. Depression in primary care: linking clinical and systems strategies. Gen Hosp Psychiatry 2001; 23: 311–318PubMedCrossRef
115.
go back to reference Nutting PA, Rost K, Dickinson M, et al. Barriers to initiating depression treatment in primary care practice. J Gen Intern Med 2002; 17: 103–111PubMedCrossRef Nutting PA, Rost K, Dickinson M, et al. Barriers to initiating depression treatment in primary care practice. J Gen Intern Med 2002; 17: 103–111PubMedCrossRef
116.
go back to reference Baik S, Bowers BJ, Oakley LD, et al. The recognition of depression: the primary care clinician’s perspective. Ann Fam Med 2005; 3: 31–37PubMedCrossRef Baik S, Bowers BJ, Oakley LD, et al. The recognition of depression: the primary care clinician’s perspective. Ann Fam Med 2005; 3: 31–37PubMedCrossRef
117.
go back to reference Frank RG. Huskamp HA, Pincus HA. Aligning incentives in the treatment of depression in primary care with evidence based practice. Psychiatr Serv 2003; 54 (5): 682–687PubMedCrossRef Frank RG. Huskamp HA, Pincus HA. Aligning incentives in the treatment of depression in primary care with evidence based practice. Psychiatr Serv 2003; 54 (5): 682–687PubMedCrossRef
118.
go back to reference Kilbourne AM, Schulberg HC, Post EP, et al. Translating evidence-based depression management services to community-based primary care practices. Milbank Q 2004; 82 (4): 631–659PubMedCrossRef Kilbourne AM, Schulberg HC, Post EP, et al. Translating evidence-based depression management services to community-based primary care practices. Milbank Q 2004; 82 (4): 631–659PubMedCrossRef
119.
go back to reference Schoenbaum M, Kelleher K, Lave JR, et al. Exploratory evidence on the market for effective depression care in Pittsburgh. Psychiatr Serv 2004; 55 (4): 392–395PubMedCrossRef Schoenbaum M, Kelleher K, Lave JR, et al. Exploratory evidence on the market for effective depression care in Pittsburgh. Psychiatr Serv 2004; 55 (4): 392–395PubMedCrossRef
120.
go back to reference Simon GE, Von Korff M, Wagner EH, et al. Patterns of antidepressant use in community practice. Gen Hosp Psychiatry 1993; 15: 399–408PubMedCrossRef Simon GE, Von Korff M, Wagner EH, et al. Patterns of antidepressant use in community practice. Gen Hosp Psychiatry 1993; 15: 399–408PubMedCrossRef
121.
122.
go back to reference Goldman HH. Justifying mental health care costs. Health Aff 1999; 18 (2): 94–95CrossRef Goldman HH. Justifying mental health care costs. Health Aff 1999; 18 (2): 94–95CrossRef
123.
go back to reference Pirraglia PA, Rosen AB, Hermann RC, et al. Cost-utility analysis studies of depression management: a systematic review. Am J Psychiatry 2004; 161 (12): 2155–2162PubMedCrossRef Pirraglia PA, Rosen AB, Hermann RC, et al. Cost-utility analysis studies of depression management: a systematic review. Am J Psychiatry 2004; 161 (12): 2155–2162PubMedCrossRef
124.
go back to reference Laupacis A, Feeny D, Detsky A, et al. How attractive does a new technology have to be to warrant adoption and utilization? Tentative guidelines for using clinical and economic evaluations. Can Med Assoc J 1992; 146 (4): 473–481 Laupacis A, Feeny D, Detsky A, et al. How attractive does a new technology have to be to warrant adoption and utilization? Tentative guidelines for using clinical and economic evaluations. Can Med Assoc J 1992; 146 (4): 473–481
125.
go back to reference Unutzer J, Katon WJ, Russo J, et al. Willingness to pay for depression treatment in primary care. Psychiatr Serv 2003; 54 (3): 340–345PubMedCrossRef Unutzer J, Katon WJ, Russo J, et al. Willingness to pay for depression treatment in primary care. Psychiatr Serv 2003; 54 (3): 340–345PubMedCrossRef
126.
go back to reference Frank HG, McGuire TG, Normand LT, et al. The value of mental health care at the system level: the case of treating depression. Health Aff 1999; 18 (5): 71–88CrossRef Frank HG, McGuire TG, Normand LT, et al. The value of mental health care at the system level: the case of treating depression. Health Aff 1999; 18 (5): 71–88CrossRef
Metadata
Title
Reducing the Societal Burden of Depression
A Review of Economic Costs, Quality of Care and Effects of Treatment
Authors
Dr Julie M. Donohue
Harold Alan Pincus
Publication date
01-01-2007
Publisher
Springer International Publishing
Published in
PharmacoEconomics / Issue 1/2007
Print ISSN: 1170-7690
Electronic ISSN: 1179-2027
DOI
https://doi.org/10.2165/00019053-200725010-00003

Other articles of this Issue 1/2007

PharmacoEconomics 1/2007 Go to the issue