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01-01-2009 | Biological Child and Adolescent Psychiatry - Short Communication

Reduced serotonergic functioning changes heart rate in ADHD

Authors: Florian Daniel Zepf, M. Holtmann, C. Stadler, L. Wöckel, F. Poustka

Published in: Journal of Neural Transmission | Issue 1/2009

Abstract

Reduced mean heart rate (HR) was shown to be a biophysiological marker for aggression, which in turn was proven to be related to changed serotonergic neurotransmission. A total of 16 ADHD-diagnosed boys were subjected to rapid tryptophan depletion (RTD) and a placebo in a double-blind within-subject crossover-design. Mean HR was assessed under RTD/placebo. Low impulsive patients behaving aggressively under RTD showed a lowered HR under RTD versus placebo. Diminished 5-HT functioning was associated with lowered HR and aggressive behaviour.

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Title: Reduced serotonergic functioning changes heart rate in ADHD
Authors: Florian Daniel Zepf
M. Holtmann
C. Stadler
L. Wöckel
F. Poustka
Publication date: 01-01-2009
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 1/2009
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0146-0

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Reduced serotonergic functioning changes heart rate in ADHD

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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