Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Behavioral and Brain Functions
Published in: Behavioral and Brain Functions 1/2014

Open Access 01-12-2014 | Research

Reduced resting-state brain activity in the default mode network in children with (central) auditory processing disorders

Authors: Agnieszka Pluta, Tomasz Wolak, Natalia Czajka, Monika Lewandowska, Katarzyna Cieśla, Mateusz Rusiniak, Diana Grudzień, Henryk Skarżyński

Published in: Behavioral and Brain Functions | Issue 1/2014

Login to get access

Abstract

Background

In recent years, there has been a growing interest in Central Auditory Processing Disorder (C)APD. However, the neural correlates of (C)APD are poorly understood. Previous neuroimaging experiments have shown changes in the intrinsic activity of the brain in various cognitive deficits and brain disorders. The present study investigated the spontaneous brain activity in (C)APD subjects with resting-state fMRI (rs-fMRI).

Methods

Thirteen children diagnosed with (C)APD and fifteen age and gender-matched controls participated in a rs-fMRI study during which they were asked to relax keeping their eyes open. Two different techniques of the rs-fMRI data analysis were used: Regional Homogeneity (ReHo) and Independent Component Analysis (ICA), which approach is rare.

Results

Both methods of data analysis showed comparable results in the pattern of DMN activity within groups. Additionally, ReHo analysis revealed increased co-activation of the superior frontal gyrus, the posterior cingulate cortex/the precuneus in controls, compared to the (C)APD group. ICA yielded inconsistent results across groups.

Conclusions

Our ReHo results suggest that (C)APD children seem to present reduced regional homogeneity in brain regions considered a part of the default mode network (DMN). These findings might contribute to a better understanding of neural mechanisms of (C)APD.
Appendix
Available only for authorised users
Literature
1.
Moore DR, Ferguson MA, Edmondson-Jones AM, Ratib S, Riley A: Nature of auditory processing disorder in children. Pediatrics. 2010, 126: e382-e390. 10.1542/peds.2009-2826.CrossRefPubMed
2.
Bamiou D-E, Musiek FE, Luxon LM: Aetiology and clinical presentations of auditory processing disorders—a review. Arch Dis Child. 2001, 85: 361-365. 10.1136/adc.85.5.361.PubMedCentralCrossRefPubMed
3.
Bailey T: Auditory pathways and processes: implications for neuropsychological assessment and diagnosis of children and adolescents. Child Neuropsychol. 2010, 16: 521-548. 10.1080/09297041003783310.CrossRefPubMed
4.
Kim M-J, Jeon H-A, Lee K-M, Son Y-D, Kim Y-B, Cho Z-H: Neuroimaging features in a case of developmental central auditory processing disorder. J Neurol Sci. 2009, 277: 176-180. 10.1016/j.jns.2008.10.020.CrossRefPubMed
5.
Bartel-Friedrich S, Broecker Y, Knoergen M, Koesling S: Development of fMRI tests for children with central auditory processing disorders. In Vivo. 2010, 24: 201-209.PubMed
6.
Snyder AZ, Raichle ME: A brief history of the resting state: the Washington University perspective. NeuroImage. 2012, 62: 902-910. 10.1016/j.neuroimage.2012.01.044.PubMedCentralCrossRefPubMed
7.
Assaf M, Jagannathan K, Calhoun VD, Miller L, Stevens MC, Sahl R, O’Boyle JG, Schultz RT, Pearlson GD: Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients. NeuroImage. 2010, 53: 247-256. 10.1016/j.neuroimage.2010.05.067.PubMedCentralCrossRefPubMed
8.
Camchong J, MacDonald AW, Bell C, Mueller BA, Lim KO: Altered functional and anatomical connectivity in schizophrenia. Schizophr Bull. 2011, 37: 640-650. 10.1093/schbul/sbp131.PubMedCentralCrossRefPubMed
9.
Buckner RL, Andrews-Hanna JR, Schacter DL: The brain’s default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci. 2008, 1124: 1-38. 10.1196/annals.1440.011.CrossRefPubMed
10.
Leech R, Kamourieh S, Beckmann CF, Sharp DJ: Fractionating the default mode network: distinct contributions of the ventral and dorsal posterior cingulate cortex to cognitive control. J Neurosci. 2011, 31: 3217-3224. 10.1523/JNEUROSCI.5626-10.2011.CrossRefPubMed
11.
Hinds O, Thompson TW, Ghosh S, Yoo JJ, Whitfield-Gabrieli S, Triantafyllou C, Gabrieli JDE: Roles of default-mode network and supplementary motor area in human vigilance performance: evidence from real-time fMRI. J Neurophysiol. 2013, 109: 1250-1258. 10.1152/jn.00533.2011.CrossRefPubMed
12.
Bonnelle V, Leech R, Kinnunen KM, Ham TE, Beckmann CF, Boissezon XD, Greenwood RJ, Sharp DJ: Default mode network connectivity predicts sustained attention deficits after traumatic brain injury. J Neurosci. 2011, 31: 13442-13451. 10.1523/JNEUROSCI.1163-11.2011.CrossRefPubMed
13.
Broyd SJ, Demanuele C, Debener S, Helps SK, James CJ, Sonuga-Barke EJS: Default-mode brain dysfunction in mental disorders: a systematic review. Neurosci Biobehav Rev. 2009, 33: 279-296. 10.1016/j.neubiorev.2008.09.002.CrossRefPubMed
14.
Bell SM, McCallum RS, Cox EA: Toward a research-based assessment of dyslexia: using cognitive measures to identify reading disabilities. J Learn Disabil. 2003, 36: 505-516. 10.1177/00222194030360060201.CrossRefPubMed
15.
Riccio CA, Cohen MJ, Garrison T, Smith B: Auditory processing measures: correlation with neuropsychological measures of attention, memory, and behavior. Child Neuropsychol. 2005, 11: 363-372. 10.1080/09297040490916956.CrossRefPubMed
16.
Chermak GD, Somers EK, Seikel JA: Behavioral signs of central auditory processing disorder and attention deficit hyperactivity disorder. J Am Acad Audiol. 1998, 9: 78-84.PubMed
17.
Hoeksma MR, Kenemans JL, Kemner C, van Engeland H: Variability in spatial normalization of pediatric and adult brain images. Clin Neurophysiol. 2005, 116: 1188-1194. 10.1016/j.clinph.2004.12.021.CrossRefPubMed
18.
Castellanos FX, Margulies DS, Kelly AMC, Uddin LQ, Ghaffari M, Kirsch A, Shaw D, Shehzad Z, Di Martino A, Biswal B, Sonuga-Barke EJS, Rotrosen J, Adler LA, Milham MP: Cingulate - precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder. Biol Psychiatry. 2008, 63: 332-337. 10.1016/j.biopsych.2007.06.025.PubMedCentralCrossRefPubMed
19.
Cao Q, Zang Y, Sun L, Sui M, Long X, Zou Q, Wang Y: Abnormal neural activity in children with attention deficit hyperactivity disorder: a resting-state functional magnetic resonance imaging study. Neuroreport. 2006, 17: 1033-1036. 10.1097/01.wnr.0000224769.92454.5d.CrossRefPubMed
20.
Weissman DH, Roberts KC, Visscher KM, Woldorff MG: The neural bases of momentary lapses in attention. Nat Neurosci. 2006, 9: 971-978. 10.1038/nn1727.CrossRefPubMed
21.
Sonuga-Barke EJS, Castellanos FX: Spontaneous attentional fluctuations in impaired states and pathological conditions: a neurobiological hypothesis. Neurosci Biobehav Rev. 2007, 31: 977-986. 10.1016/j.neubiorev.2007.02.005.CrossRefPubMed
22.
Calhoun VD, Adali T, Pearlson GD, Pekar JJ: A method for making group inferences from functional MRI data using independent component analysis. Hum Brain Mapp. 2001, 14: 140-151. 10.1002/hbm.1048.CrossRefPubMed
23.
Ding X, Lee S-W: Cocaine addiction related reproducible brain regions of abnormal default-mode network functional connectivity: a group ICA study with different model orders. Neurosci Lett. 2013, 548: 110-114.CrossRefPubMed
24.
Allen EA, Damaraju E, Plis SM, Erhardt EB, Eichele T, Calhoun VD: Tracking whole-brain connectivity dynamics in the resting state. Cereb Cortex. 2014, 24: 663-676. 10.1093/cercor/bhs352.PubMedCentralCrossRefPubMed
25.
Damoiseaux JS, Beckmann CF, Arigita EJ, Barkhof F, Scheltens P, Stam CJ, Smith SM, Rombouts SA: Reduced resting-state brain activity in the “default network” in normal aging. Cereb Cortex. 2008, 18: 1856-1864. 10.1093/cercor/bhm207.CrossRefPubMed
26.
Raichle ME, Snyder AZ: A default mode of brain function: a brief history of an evolving idea. NeuroImage. 2007, 37: 1083-1090. 10.1016/j.neuroimage.2007.02.041.CrossRefPubMed
27.
Lancaster JL, Woldorff MG, Parsons LM, Liotti M, Freitas CS, Rainey L, Kochunov PV, Nickerson D, Mikiten SA, Fox PT: Automated Talairach atlas labels for functional brain mapping. Hum Brain Mapp. 2000, 10: 120-131. 10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8.CrossRefPubMed
28.
Van Dijk KRA, Sabuncu MR, Buckner RL: The influence of head motion on intrinsic functional connectivity MRI. NeuroImage. 2012, 59: 431-438. 10.1016/j.neuroimage.2011.07.044.PubMedCentralCrossRefPubMed
29.
Power JD, Mitra A, Laumann TO, Snyder AZ, Schlaggar BL, Petersen SE: Methods to detect, characterize, and remove motion artifact in resting state fMRI. NeuroImage. 2014, 84: 320-341.CrossRefPubMed
30.
Rombouts SARB, Damoiseaux JS, Goekoop R, Barkhof F, Scheltens P, Smith SM, Beckmann CF: Model‒free group analysis shows altered BOLD FMRI networks in dementia. Hum Brain Mapp. 2009, 30: 256-266. 10.1002/hbm.20505.CrossRefPubMed
31.
Leech R, Braga R, Sharp DJ: Echoes of the brain within the posterior cingulate cortex. J Neurosci Off J Soc Neurosci. 2012, 32: 215-222. 10.1523/JNEUROSCI.3689-11.2012.CrossRef
32.
Pearson JM, Heilbronner SR, Barack DL, Hayden BY, Platt ML: Posterior cingulate cortex: adapting behavior to a changing world. Trends Cogn Sci. 2011, 15: 143-151. 10.1016/j.tics.2011.02.002.PubMedCentralCrossRefPubMed
33.
Uddin LQ, Kelly AMC, Biswal BB, Margulies DS, Shehzad Z, Shaw D, Ghaffari M, Rotrosen J, Adler LA, Castellanos FX, Milham MP: Network homogeneity reveals decreased integrity of default-mode network in ADHD. J Neurosci Methods. 2008, 169: 249-254. 10.1016/j.jneumeth.2007.11.031.CrossRefPubMed
34.
Cacace AT, McFarland DJ: The importance of modality specificity in diagnosing central auditory processing disorder. Am J Audiol. 2005, 14: 112-123. 10.1044/1059-0889(2005/012).CrossRefPubMed
35.
Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE: Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage. 2012, 59: 2142-2154. 10.1016/j.neuroimage.2011.10.018.PubMedCentralCrossRefPubMed
36.
De Celis Alonso B, Hidalgo Tobón S, Dies Suarez P, García Flores J, De Celis Carrillo B, Barragán Pérez E: A multi-methodological MR resting state network analysis to assess the changes in brain physiology of children with ADHD. PLoS One. 2014, 9: e99119-10.1371/journal.pone.0099119.PubMedCentralCrossRef
37.
Cole DM, Smith SM, Beckmann CF: Advances and pitfalls in the analysis and interpretation of resting-state FMRI data. Front Syst Neurosci. 2010, 4: 8-PubMedCentralPubMed
38.
Beckmann CF, Smith SM: Tensorial extensions of independent component analysis for multisubject FMRI analysis. NeuroImage. 2005, 25: 294-311. 10.1016/j.neuroimage.2004.10.043.CrossRefPubMed
39.
Liu C-H, Ma X, Li F, Wang Y-J, Tie C-L, Li S-F, Chen T-L, Fan T, Zhang Y, Dong J, Yao L, Wu X, Wang C-Y: Regional homogeneity within the default mode network in bipolar depression: a resting-state functional magnetic resonance imaging study. PLoS One. 2012, 7: e48181-10.1371/journal.pone.0048181.PubMedCentralCrossRefPubMed
40.
Von dem Hagen EAH, Stoyanova RS, Baron-Cohen S, Calder AJ: Reduced functional connectivity within and between “social” resting state networks in autism spectrum conditions. Soc Cogn Affect Neurosci. 2013, 8 (6): 694-701. 10.1093/scan/nss053.PubMedCentralCrossRefPubMed
41.
Valsasina P, Rocca M, Misci P, Pagani E, Falini A, Filippi M: Proceedings of The International Society for Magnetic Resonance in Medicine. 2009, Honolulu, Hawai’i, USA
Metadata
Title
Reduced resting-state brain activity in the default mode network in children with (central) auditory processing disorders
Authors
Agnieszka Pluta
Tomasz Wolak
Natalia Czajka
Monika Lewandowska
Katarzyna Cieśla
Mateusz Rusiniak
Diana Grudzień
Henryk Skarżyński
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Behavioral and Brain Functions / Issue 1/2014
Electronic ISSN: 1744-9081
DOI
https://doi.org/10.1186/1744-9081-10-33

Other articles of this Issue 1/2014

Behavioral and Brain Functions 1/2014 Go to the issue

Research

Prefrontal cortical and striatal transcriptional responses to the reinforcing effect of repeated methylphenidate treatment in the spontaneously hypertensive rat, animal model of attention-deficit/hyperactivity disorder (ADHD)

Research

A key role for an impaired detoxification mechanism in the etiology and severity of autism spectrum disorders

Research

A common haplotype of KIAA0319 contributes to the phonological awareness skill in Chinese children

Research

Verbal learning in the context of background music: no influence of vocals and instrumentals on verbal learning

Research

Colour vision in ADHD: Part 1 - Testing the retinal dopaminergic hypothesis

Research

Mathematical anxiety is linked to reduced cognitive reflection: a potential road from discomfort in the mathematics classroom to susceptibility to biases