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BMC Neurology

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Open Access 01-12-2010 | Case report

Recurrent myelitis after allogeneic stem cell transplantation. Report of two cases

Authors: Martin Voß, Felix Bischof

Published in: BMC Neurology | Issue 1/2010

Abstract

Background

Allogeneic and autologous haematopoietic stem cell transplantation are established treatment options for haematological malignancies and may possibly be employed to treat a range of genetic and autoimmune diseases.

Case presentation

We report two patients who developed an acute myelitis within their thoracic spinal cord after allogeneic stem cell transplantation. Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.

Conclusions

Myelitis is a possibly disabling consequence of haematopoietic stem cell transplantation.

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Saiz A, Graus F: Neurological complications of hematopoietic cell transplantation. Semin Neurol. 2004, 24: 427-34. 10.1055/s-2004-861537.CrossRefPubMed

de Lima M, Couriel D, Thall PF, Wang X, Madden T, Jones R, Shpall EJ, Shahjahan M, Pierre B, Giralt S, et al: Once-daily intravenous busulfan and fludarabine: clinical and pharmacokinetic results of a myeloablative, reduced-toxicity conditioning regimen for allogeneic stem cell transplantation in AML and MDS. Blood. 2004, 104: 857-64. 10.1182/blood-2004-02-0414.CrossRefPubMed

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Mondria T, Lamers CH, te Boekhorst PA, Gratama JW, Hintzen RQ: Bone-marrow transplantation fails to halt intrathecal lymphocyte activation in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2008, 79: 1013-5. 10.1136/jnnp.2007.133520.CrossRefPubMed

The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2377/10/76/prepub

Title: Recurrent myelitis after allogeneic stem cell transplantation. Report of two cases
Authors: Martin Voß
Felix Bischof
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: BMC Neurology / Issue 1/2010
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/1471-2377-10-76

At a glance: The STEP trials

Springer Medicine

Recurrent myelitis after allogeneic stem cell transplantation. Report of two cases

Abstract

Background

Case presentation

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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