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Published in: European Journal of Medical Research 1/2014

Open Access 01-12-2014 | Case report

Recurrent lymphocytic myocarditis in a young male with ulcerative colitis

Authors: Varnavas C Varnavas, Nico Reinsch, Mareike Perrey, Felix Nensa, Thomas Schlosser, Hideo A Baba, Guido Gerken, Raimund Erbel, Rolf A Janosi, Antonios Katsounas

Published in: European Journal of Medical Research | Issue 1/2014

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Abstract

Awareness of myocarditis in association with inflammatory bowel diseases is crucial as it bears a rare but serious risk for mortality. This report describes the case of a young Caucasian male, whose heart biopsy was tested negative for giant cells and bacterial or viral genomes or proteins. He was experiencing severe lymphocytic myocarditis (other than mesalamine-induced) along with cardiogenic shock during ulcerative colitis exacerbation. This is an extremely rare, if not unique, clinical constellation. We chose to study the epidemiologic grounds and all major aspects of differential pathogenesis and treatment of this serious health problem.
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Literature
1.
go back to reference Mowat NA, Bennett PN, Finlayson JK, Brunt PW, Lancaster WM: Myopericarditis complicating ulcerative colitis. Br Heart J 1974, 36: 724–727. 10.1136/hrt.36.7.724PubMedPubMedCentralCrossRef Mowat NA, Bennett PN, Finlayson JK, Brunt PW, Lancaster WM: Myopericarditis complicating ulcerative colitis. Br Heart J 1974, 36: 724–727. 10.1136/hrt.36.7.724PubMedPubMedCentralCrossRef
2.
go back to reference Sorensen HT, Fonager KM: Myocarditis and inflammatory bowel disease. A 16-year Danish nationwide cohort study. Dan Med Bull 1997, 44: 442–444.PubMed Sorensen HT, Fonager KM: Myocarditis and inflammatory bowel disease. A 16-year Danish nationwide cohort study. Dan Med Bull 1997, 44: 442–444.PubMed
3.
4.
go back to reference Davidoff R, Palacios I, Southern J, Fallon JT, Newell J, Dec GW: Giant cell versus lymphocytic myocarditis. A comparison of their clinical features and long-term outcomes. Circulation 1991, 83: 953–961. 10.1161/01.CIR.83.3.953PubMedCrossRef Davidoff R, Palacios I, Southern J, Fallon JT, Newell J, Dec GW: Giant cell versus lymphocytic myocarditis. A comparison of their clinical features and long-term outcomes. Circulation 1991, 83: 953–961. 10.1161/01.CIR.83.3.953PubMedCrossRef
5.
go back to reference Cooper LT Jr, Berry GJ, Shabetai R: Idiopathic giant-cell myocarditis – natural history and treatment. N Engl J Med 1860–1866, 1997: 336. Cooper LT Jr, Berry GJ, Shabetai R: Idiopathic giant-cell myocarditis – natural history and treatment. N Engl J Med 1860–1866, 1997: 336.
6.
go back to reference Davies MJ, Pomerance A, Teare RD: Idiopathic giant cell myocarditis – a distinctive clinico-pathological entity. Br Heart J 1975, 37: 192–195. 10.1136/hrt.37.2.192PubMedPubMedCentralCrossRef Davies MJ, Pomerance A, Teare RD: Idiopathic giant cell myocarditis – a distinctive clinico-pathological entity. Br Heart J 1975, 37: 192–195. 10.1136/hrt.37.2.192PubMedPubMedCentralCrossRef
7.
go back to reference Frustaci A, Chimenti C, Calabrese F, Pieroni M, Thiene G, Maseri A: Immunosuppressive therapy for active lymphocytic myocarditis: virological and immunologic profile of responders versus nonresponders. Circulation 2003, 107: 857–863. 10.1161/01.CIR.0000048147.15962.31PubMedCrossRef Frustaci A, Chimenti C, Calabrese F, Pieroni M, Thiene G, Maseri A: Immunosuppressive therapy for active lymphocytic myocarditis: virological and immunologic profile of responders versus nonresponders. Circulation 2003, 107: 857–863. 10.1161/01.CIR.0000048147.15962.31PubMedCrossRef
8.
go back to reference Mason JW, O’Connell JB, Herskowitz A, Rose NR, McManus BM, Billingham ME, Moon TE: A clinical trial of immunosuppressive therapy for myocarditis. N Engl J Med 1995, 333: 269–275. 10.1056/NEJM199508033330501PubMedCrossRef Mason JW, O’Connell JB, Herskowitz A, Rose NR, McManus BM, Billingham ME, Moon TE: A clinical trial of immunosuppressive therapy for myocarditis. N Engl J Med 1995, 333: 269–275. 10.1056/NEJM199508033330501PubMedCrossRef
9.
go back to reference Wojnicz R, Nowalany-Kozielska E, Wojciechowska C, Glanowska G, Wilczewski P, Niklewski T, Zembala M, Polonski L, Rozek MM, Wodniecki J: Randomized, placebo-controlled study for immunosuppressive treatment of inflammatory dilated cardiomyopathy: two-year follow-up results. Circulation 2001, 104: 39–45. 10.1161/01.CIR.104.1.39PubMedCrossRef Wojnicz R, Nowalany-Kozielska E, Wojciechowska C, Glanowska G, Wilczewski P, Niklewski T, Zembala M, Polonski L, Rozek MM, Wodniecki J: Randomized, placebo-controlled study for immunosuppressive treatment of inflammatory dilated cardiomyopathy: two-year follow-up results. Circulation 2001, 104: 39–45. 10.1161/01.CIR.104.1.39PubMedCrossRef
10.
go back to reference Maisch B, Seferovic PM, Ristic AD, Erbel R, Rienmuller R, Adler Y, Tomkowski WZ, Thiene G, Yacoub MH: Guidelines on the diagnosis and management of pericardial diseases executive summary. Eur Heart J 2004, 25: 587–610.PubMedCrossRef Maisch B, Seferovic PM, Ristic AD, Erbel R, Rienmuller R, Adler Y, Tomkowski WZ, Thiene G, Yacoub MH: Guidelines on the diagnosis and management of pericardial diseases executive summary. Eur Heart J 2004, 25: 587–610.PubMedCrossRef
11.
go back to reference Stelts S, Taylor MH, Nappi J, Van Bakel AB: Mesalamine-associated hypersensitivity myocarditis in ulcerative colitis. Ann Pharmacother 2008, 42: 904–905. 10.1345/aph.1K288PubMedCrossRef Stelts S, Taylor MH, Nappi J, Van Bakel AB: Mesalamine-associated hypersensitivity myocarditis in ulcerative colitis. Ann Pharmacother 2008, 42: 904–905. 10.1345/aph.1K288PubMedCrossRef
12.
go back to reference Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ: A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981, 30: 239–245. 10.1038/clpt.1981.154PubMedCrossRef Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ: A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981, 30: 239–245. 10.1038/clpt.1981.154PubMedCrossRef
Metadata
Title
Recurrent lymphocytic myocarditis in a young male with ulcerative colitis
Authors
Varnavas C Varnavas
Nico Reinsch
Mareike Perrey
Felix Nensa
Thomas Schlosser
Hideo A Baba
Guido Gerken
Raimund Erbel
Rolf A Janosi
Antonios Katsounas
Publication date
01-12-2014
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 1/2014
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/2047-783X-19-11

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