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01-01-2006 | Case Report

Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation

Authors: Florian Grabellus, Sien-Yi Sheu, Boris Schmidt, Michael Flasshove, Cornelius Kuhnen, Steffen Ruchholtz, Georg Taeger, Kurt Werner Schmid

Published in: Virchows Archiv | Issue 1/2006

Abstract

Leiomyosarcomas (LM) of the soft tissue comprise approximately 5–10% of all soft tissue sarcomas. Besides the classic LM, several distinctly uncommon features of the cellular and growth patterns of LM have been described. The term “dedifferentiated LM” has rarely been used in the literature to describe soft tissue LM containing areas of undifferentiated, pleomorphic appearance or detectable heterologous differentiation. We report on a case of high-grade LM with almost entire transition to an osteosarcoma, which was classified as recurrent high-grade LM with heterologous osteosarcomatous differentiation. The identification of areas with osteosarcomatous dedifferentiation in soft tissue sarcomas can be of clinical importance because of a possible change in oncologic treatment strategies.

Ahmad SA, Patel SR, Ballo MT, Baker TP, Yasko AW, Wang X, Feig BW, Hunt KK, Lin PP, Weber KL, Chen LL, Zagars GK, Pollock RE, Benjamin RS, Pisters PW (2002) Extraosseous osteosarcoma: response to treatment and long-term outcome. J Clin Oncol 20:521–527PubMedCrossRef

Aru A, Norup P, Bjerregaard B, Andreasson B, Horn T (2001) Osteoclast-like giant cells in leiomyomatous tumors of the uterus. A case report and review of the literature. Acta Obstet Gynecol Scand 80:371–374PubMedCrossRef

Brady MS, Perino G, Tallini G, Russo P, Woodruff JM (1996) Malignant mesenchymoma. Cancer 77:467–473PubMedCrossRef

Feeley C, Gallagher P, Lang D (2005) Osteosarcoma arising in a metastatic leiomyosarcoma. Histopathology 46:111–113PubMedCrossRef

Fletcher CD (1994) The histological features of local recurrences of soft tissue sarcomas. Pathologe 15:196–200PubMedCrossRef

Fletcher CDM, Unni KK, Mertens FE (eds) (2002) World Health Organization classification of tumours. Pathology and genetics of tumors of soft tissue and bone. IARC Press, Lyon

Gazziola C, Cordani N, Wasserman B, Carta S, Colombatti A, Perris R (2003) Malignant fibrous histiocytoma: a proposed cellular origin and identification of its characterizing gene transcripts. Int J Oncol 23:343–351PubMed

Goldstein-Jackson SY, Gosheger G, Delling G, Berdel WE, Exner GU, Jundt G, Machatschek JN, Zoubek A, Jurgens H, Bielack SS (2005) Extraskeletal osteosarcoma has a favourable prognosis when treated like conventional osteosarcoma. J Cancer Res Clin Oncol. DOI 10.1007/s00432-005-0687-7 (published online first: 26 May 2005)

Hass R (1994) Retrodifferentiation and cell death. Crit Rev Oncog 5:359–371PubMed

10.

Henricks WH, Chu YC, Goldblum JR, Weiss SW (1997) Dedifferentiated liposarcoma: a clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation. Am J Surg Pathol 21:271–281PubMedCrossRef

11.

Insabato L, Di Vizio D, Ciancia G, Pettinato G, Tornillo L, Terracciano L (2004) Malignant gastrointestinal leiomyosarcoma and gastrointestinal stromal tumor with prominent osteoclast-like giant cells. Arch Pathol Lab Med 128:440–443PubMed

12.

Kew CC, Putti TC, Razvi K (2004) Malignant mesenchymoma arising from a uterine leiomyoma in the menopause. Gynecol Oncol 95:712–715PubMedCrossRef

13.

Lidang JM, Schumacher B, Myhre JO, Steen NO, Keller J (1998) Extraskeletal osteosarcomas: a clinicopathologic study of 25 cases. Am J Surg Pathol 22:588–594CrossRef

14.

Mentzel T, Calonje E, Fletcher CD (1994) Leiomyosarcoma with prominent osteoclast-like giant cells. Analysis of eight cases closely mimicking the so-called giant cell variant of malignant fibrous histiocytoma. Am J Surg Pathol 18:258–265PubMed

15.

Mentzel T, Fletcher CD (1994) Malignant mesenchymomas of soft tissue associated with numerous osteoclast-like giant cells mimicking the so-called giant cell variant of “malignant fibrous histiocytoma”. Virchows Arch 424:539–545PubMedCrossRef

16.

Newman PL, Fletcher CD (1991) Malignant mesenchymoma. Clinicopathologic analysis of a series with evidence of low-grade behaviour. Am J Surg Pathol 15:607–614PubMedCrossRef

17.

Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414:105–111PubMedCrossRef

18.

Roncaroli F, Eusebi V (1996) Rhabdomyoblastic differentiation in a leiomyosarcoma of the retroperitoneum. Hum Pathol 27:310–313PubMedCrossRef

19.

Rubin BP, Fletcher CD (2000) Myxoid leiomyosarcoma of soft tissue, an underrecognized variant. Am J Surg Pathol 24:927–936PubMedCrossRef

20.

Suster S, Wong TY, Moran CA (1993) Sarcomas with combined features of liposarcoma and leiomyosarcoma. Study of two cases of an unusual soft-tissue tumor showing dual lineage differentiation. Am J Surg Pathol 17:905–911PubMedCrossRef

21.

Tosh D, Slack JM (2002) How cells change their phenotype. Nat Rev Mol Cell Biol 3:187–194PubMedCrossRef

22.

Weiss SW, Goldblum JR (eds) (2001) Enzinger and Weiss's soft tissue tumors, 4th edn. Mosby, St. Louis, MO

Title: Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation
Authors: Florian Grabellus
Sien-Yi Sheu
Boris Schmidt
Michael Flasshove
Cornelius Kuhnen
Steffen Ruchholtz
Georg Taeger
Kurt Werner Schmid
Publication date: 01-01-2006
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 1/2006
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-005-0094-0

2024 ASCO Annual Meeting

Springer Medicine

Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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