Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Surgery
Published in: BMC Surgery 1/2020

Open Access 01-12-2020 | Case report

Recurrent granular cell tumor of the thyroid: a case report and literature review

Authors: Yu-qin He, Hai-zhen Lu, De-zhi Li, Mo-qi Chen, Kai Wang, Zhen-gang Xu, Shao-yan Liu

Published in: BMC Surgery | Issue 1/2020

Login to get access

Abstract

Background

Granular cell tumor (GCT) of the thyroid is a rare benign tumor of Schwann cell origin with a favorable prognosis and only 10 cases have been reported so far in scientific literature. The present case study describes the first case of recurrent thyroid GCT.

Case presentation

Our case describes a 20-year-old woman who had undergone lobectomy for GCT of the thyroid 4 years ago. Hematoxylin-eosin (HE) staining revealed that the lesion was composed of epithelioid cells with an abundance of eosinophilic granular cytoplasm. Immunohistochemical analysis showed that tumor cells tested positive for S-100 protein and negative for desmin. Both histological and immunohistochemical analyses supported the diagnosis of recurrent GCT of the thyroid.

Conclusions

Our case suggested that a tumor-free margin excision and post-operative follow-up are necessary for the treatment of GCT of the thyroid.
Literature
1.
Abrikossoff A. Uber Myome ausgehend von der quergestreiften willkurlichen Muskulatur. Virchows Arch. 1962;260:215–33..CrossRef
2.
Fliss DM, Puterman M, Zirkin H, Leiberman A. Granular cell lesions in head and neck: a clinicopathological study. J Surg Oncol. 1989;42(3):154–60.CrossRef
3.
Kershisnik M, Batsakis JG, Mackay B. Granular cell tumors. Ann Otol Rhinol Laryngol. 1994;103(5 Pt 1):416–9.CrossRef
4.
Jobrack AD, Goel S, Cotlar AM. Granular cell tumor: report of 13 cases in a veterans administration hospital. Mil Med. 2018;183:e589–93.CrossRef
5.
Koltsidopoulos P, Chaidas K, Chlopsidis P, Skoulakis C. Granular cell (Abrikossoff) tumor in the head and neck: a series of 5 cases. Ear Nose Throat J. 2016;95(1):36–9.PubMed
6.
Gupta N, Sanchety N, Verma PS, Verma G. Malignant granular cell tumor of the breast; literature review. Indian J Pathol Microbiol. 2015;58(2):238–40.CrossRef
7.
Mahoney CP, Patterson SD, Ryan J. Granular cell tumor of the thyroid gland in a girl receiving high-dose estrogen therapy. Pediatr Pathol Lab Med. 1995;15(5):791–5.CrossRef
8.
Paproski SM, Owen DA. Granular cell tumor of the thyroid. Arch Pathol Lab Med. 2001;125(4):544–6.PubMed
9.
Milias S, Hytiroglou P, Kourtis D, Papadimitriou CS. Granular cell tumour of the thyroid gland. Histopathology. 2004;44(2):190–1.CrossRef
10.
Baloch ZW, Martin S, Livolsi VA. Granular cell tumor of the thyroid: a case report. Int J Surg Pathol. 2005;13(3):291–4.CrossRef
11.
Chang SM, Wei CK, Tseng CE. The cytology of a thyroid granular cell tumor. Endocr Pathol. 2009;20(2):137–40.CrossRef
12.
Espinosa-de-Los-Monteros-Franco VA, Martinez-Madrigal F, Ortiz-Hidalgo C. Granular cell tumor (Abrikossoff tumor) of the thyroid gland. Ann Diagn Pathol. 2009;13(4):269–71.CrossRef
13.
Bowry M, Almeida B, Jeannon JP. Granular cell tumour of the thyroid gland: a case report and review of the literature. Endocr Pathol. 2011;22(1):1–5.CrossRef
14.
Singh S, Gupta N, Sharma S, Azad RK. Aspiration cytology in the preoperative diagnosis of granular cell tumor of thyroid region in an 11-years-old female child. J Cytol. 2013;30(3):218–9.CrossRef
15.
Harp E, Caraway NP. FNA of thyroid granular cell tumor. Diagn Cytopathol. 2013;41(9):825–8.CrossRef
16.
Chen Q, Li Q, Guo L, Li S, Jiang Y. Fine needle aspiration cytology of a granular cell tumor arising in the thyroid gland: a case report and review of literature. Int J Clin Exp Pathol. 2014;7(8):5186–91.PubMedPubMedCentral
17.
Weiss SW. GJ: Ensinger and Weiss’s soft tissue Tumours. 4th ed. St Louis: Mosby Elsevier; 2008.
18.
Yilmaz AD, Unlu RE, Orbay H, Sensoz O. Recurrent granular cell tumor: how to treat. J Craniofac Surg. 2007;18(5):1187–9.CrossRef
Metadata
Title
Recurrent granular cell tumor of the thyroid: a case report and literature review
Authors
Yu-qin He
Hai-zhen Lu
De-zhi Li
Mo-qi Chen
Kai Wang
Zhen-gang Xu
Shao-yan Liu
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Surgery / Issue 1/2020
Electronic ISSN: 1471-2482
DOI
https://doi.org/10.1186/s12893-020-00814-8

Other articles of this Issue 1/2020

BMC Surgery 1/2020 Go to the issue

Research article

Delayed gastric emptying after Pancreaticoduodenectomy: a propensity score-matched analysis and clinical Nomogram study

Case report

Management of dual traumatic arterial-venous fistula from a single shotgun injury: a case report and literature review

Research article

Intrahepatic cholangiocarcinoma – influence of resection margin and tumor distance to the liver capsule on survival

Case report

Internal hernia beneath superior vesical artery after pelvic lymphadenectomy for cervical cancer: a case report and literature review

Research article

Single-port laparoscopic percutaneous extraperitoneal closure for inguinal hernias repair in girls: using an epidural needle assisted by a towel forceps

Research article

Mechanisms of adhesive small bowel obstruction and outcome of surgery; a population-based study