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Skeletal Radiology
Published in: Skeletal Radiology 4/2015

01-04-2015 | Case Report

Recurrent aneurysmal bone cyst of the cervical spine in childhood treated with doxycycline injection

Authors: Anthony Doyle, Antony Field, Andrew Graydon

Published in: Skeletal Radiology | Issue 4/2015

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Abstract

A 12-year-old female was treated surgically for an aneurysmal bone cyst of the cervical spine involving the C2 and C3 vertebrae. The patient underwent surgery twice and further surgery was assessed as unfeasible. Treatment by intraosseous injection of doxycycline was uncomplicated and has resulted in resolution of the multifocal recurrent disease.
Literature
1.
Oliveira AM, Perez-Atayde AR, Inwards CY, Medeiros F, Derr V, Hsi BL, et al. USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts. Am J Pathol. 2004;165:1773–80.CrossRefPubMedCentralPubMed
2.
Mankin HJ, Hornicek FJ, Ortiz-Cruz E, Villafuerte J, Gebhardt MC. Aneurysmal bone cyst: a review of 150 patients. J Clin Oncol. 2005;23:6756–62.CrossRefPubMed
3.
Novais EN, Rose PS, Yaszemski MJ, Sim FH. Aneurysmal bone cyst of the cervical spine in children. J Bone Joint Surg Am. 2011;93:1534–43.CrossRefPubMed
4.
Perlmutter DH, Campbell S, Rubery PT, Vates EG, Silberstein HJ. Aneurysmal bone cyst. Surgical management in the pediatric cervical spine. Spine. 2009;34:E50–3.CrossRefPubMed
5.
Gurjar HK, Sarkari A, Chandra PS. Surgical management of giant multilevel aneurysmal bone cyst of cervical spine in a 10-year-old boy: case report with review of literature. Evid Based Spine Care J. 2012;3:55–9.PubMedCentralPubMed
6.
Shiels WE, Mayerson JL. Percutaneous doxycycline treatment of aneurysmal bone cysts with low recurrence rate: a preliminary report. Clin Orthop Relat Res. 2013;471:2675–83.CrossRefPubMedCentralPubMed
7.
Zenonos G, Jamil O, et al. Surgical treatment for primary spinal aneurysmal bone cysts: experience from Children’s Hospital Boston. J Neurosurg Pediatr. 2012;9:03050–030150.CrossRef
8.
Peraud A, Drake JM, Armstrong D, Hedden D, Babyn P, Wilson G. Fatal ethibloc embolization of Vertebrobasilar system following percutaneous injection into aneurysmal bone cyst of the second cervical vertebra. AJNR Am J Neuroradiol. 2004;25:1116–20.PubMed
9.
Duivenvoorden WC, Hirte HW, Singh G. Use of tetracycline as an inhibitor of matrix metalloproteinase activity secreted by human bone-metastasizing cancer cells. Invasion Metastasis. 1997;17:312–22.PubMed
10.
Gilbertson-Beadling S, Powers EA, Stamp-Cole M, Scott PS, Wallace TL, Copeland J, et al. The tetracycline analogs minocycline and doxycycline inhibit angiogenesis in vitro by a nonmetalloproteinase-dependent mechanism. Cancer Chemother Pharmacol. 1995;36:418–24.CrossRefPubMed
11.
WHO Model Formulary 2008. World Health Organization, Albany, NY. 2009. 645.
12.
Cho Y, Son HJ, et al. Doxycycline is neuroprotective against Nigral dopaminergic degeneration by a dual mechanism involving MMP-3. Neurotox Res. 2009;16:361–71.CrossRefPubMed
13.
Vanderveen N, Paran C, et al. Effectiveness and preclinical safety profile of doxycycline to be used “off-label” to induce therapeutic transgene expression in a phase I clinical trial for glioma. Hum Gen Ther Clin Dev. 2013;24:116–26.CrossRef
Metadata
Title
Recurrent aneurysmal bone cyst of the cervical spine in childhood treated with doxycycline injection
Authors
Anthony Doyle
Antony Field
Andrew Graydon
Publication date
01-04-2015
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 4/2015
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-014-2027-y

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