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European Spine Journal

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01-07-2017 | Original Article

Recurrence and survival factors analysis of 171 cases of sacral chordoma in a single institute

Authors: Yongkun Yang, Xiaohui Niu, Yuan Li, Weifeng Liu, Hairong Xu

Published in: European Spine Journal | Issue 7/2017

Abstract

Purpose

To evaluate postoperative recurrence, survival and metastasis results and related factors of sacral chordoma.

Methods

Between 1978 and 2013, a total of 171 patients with sacral chordoma were diagnosed at our institution and 162 cases underwent operation. The clinical characteristics, treatment and outcomes of all these patients were reviewed.

Results

The 3-year recurrence free survival rate was 83.1%. The median recurrence free survival time was 73 ± 7.8 months. Tumor level in sacrum and surgical margin were significant factors influencing recurrence. Recurrence was significant factor influencing metastasis. One hundred and fifty-seven cases were followed up for an average of 55.6 months. 135 cases (86%) survived, 37 cases (23.6%) developed recurrence, and 17 cases (10.8%) developed metastasis. The overall 5- and 10-year survival rate was 88.3% and 59.6%, respectively. Age (p = 0.037) and metastasis (p = 0.001) were significant factors influencing survival. The 3-year recurrence free survival rate was 80.1%. The median recurrence free survival time was 69 ± 12.7 months. Tumor level in sacrum (p = 0.035) and surgical margin (p = 0.009) were significant factors influencing recurrence. Seventeen cases (10.8%) had metastasis. Recurrence (p = 0.016) was significant factors influencing metastasis.

Conclusions

Sacral chordoma tended to occur in elderly male patients and locate below sacral 3 level. The recurrence rate was high, especially for tumor above sacral 3 level. Wide surgical margin is very important for good local control. The patients with metastasis had poor prognosis.

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Title: Recurrence and survival factors analysis of 171 cases of sacral chordoma in a single institute
Authors: Yongkun Yang
Xiaohui Niu
Yuan Li
Weifeng Liu
Hairong Xu
Publication date: 01-07-2017
Publisher: Springer Berlin Heidelberg
Published in: European Spine Journal / Issue 7/2017
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-016-4906-5

At a glance: The STEP trials

Springer Medicine

Recurrence and survival factors analysis of 171 cases of sacral chordoma in a single institute

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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