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Published in: Current Treatment Options in Oncology 10/2021

01-10-2021 | Rectal Cancer | Lower Gastrointestinal Cancers (AB Benson, Section Editor)

Lessons Learned in Managing Patients with Colorectal Cancer During the COVID-19 Pandemic

Authors: Reetu Mukherji, MD, John L. Marshall, MD

Published in: Current Treatment Options in Oncology | Issue 10/2021

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Opinion statement

The COVID-19 pandemic forced us to rapidly and dramatically shift our medical priorities and decision making. With little literature or experience to rely on, the initial priority was to minimize patient exposure to the hospital and to others. It remains unclear whether cancer patients are at higher risk of infection or serious complications, or if it is our traditional therapies that place them to be at higher risk. By far, the greatest negative impact was on screening. Routine colonoscopies were considered elective, and as a result, delays in diagnosis will be felt for years to come. The most positive changes were the incorporation of tele-visits, increased use of oral therapies, alterations in treatment schedules of both chemotherapy and radiation, and an increased emphasis on neoadjuvant therapy. These too will be felt for years to come. The colorectal cancer medical community has responded collaboratively and effectively to maintain treatment and to optimize outcomes for our patients during the COVID-19 pandemic.
Literature
1.
go back to reference Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382:1708–20.PubMedCrossRef Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382:1708–20.PubMedCrossRef
2.
go back to reference Rosenthal N, Cao Z, Gundrum J, Sianis J, Safo S. Risk factors associated with in-hospital mortality in a US national sample of patients with COVID-19. JAMA Netw Open. 2020;3:e2029058.PubMedPubMedCentralCrossRef Rosenthal N, Cao Z, Gundrum J, Sianis J, Safo S. Risk factors associated with in-hospital mortality in a US national sample of patients with COVID-19. JAMA Netw Open. 2020;3:e2029058.PubMedPubMedCentralCrossRef
3.
go back to reference Lu J, Gu J, Li K, Xu C, Su W, Lai Z, et al. COVID-19 outbreak associated with air conditioning in restaurant, Guangzhou, China, 2020. Emerg Infect Dis. 2020;26:1628–31.PubMedPubMedCentralCrossRef Lu J, Gu J, Li K, Xu C, Su W, Lai Z, et al. COVID-19 outbreak associated with air conditioning in restaurant, Guangzhou, China, 2020. Emerg Infect Dis. 2020;26:1628–31.PubMedPubMedCentralCrossRef
4.
go back to reference Madewell ZJ, Yang Y, Longini IM, Halloran ME, Dean NE. Household transmission of SARS-CoV-2: a systematic review and meta-analysis. JAMA Netw Open. 2020;3:e2031756.PubMedCrossRefPubMedCentral Madewell ZJ, Yang Y, Longini IM, Halloran ME, Dean NE. Household transmission of SARS-CoV-2: a systematic review and meta-analysis. JAMA Netw Open. 2020;3:e2031756.PubMedCrossRefPubMedCentral
5.
go back to reference Hamner L, Dubbel P, Capron I, Ross A, Jordan A, Lee J, et al. High SARS-CoV-2 Attack rate following exposure at a choir practice - Skagit County, Washington, March 2020. MMWR Morb Mortal Wkly Rep. 2020;69:606–10.PubMedCrossRef Hamner L, Dubbel P, Capron I, Ross A, Jordan A, Lee J, et al. High SARS-CoV-2 Attack rate following exposure at a choir practice - Skagit County, Washington, March 2020. MMWR Morb Mortal Wkly Rep. 2020;69:606–10.PubMedCrossRef
6.
go back to reference Marks M, Millat-Martinez P, Ouchi D, Roberts CH, Alemany A, Corbacho-Monne M, et al. Transmission of COVID-19 in 282 clusters in Catalonia, Spain: a cohort study. Lancet Infect Dis. 2021;21:629–36. Marks M, Millat-Martinez P, Ouchi D, Roberts CH, Alemany A, Corbacho-Monne M, et al. Transmission of COVID-19 in 282 clusters in Catalonia, Spain: a cohort study. Lancet Infect Dis. 2021;21:629–36.
7.
go back to reference Khanh NC, Thai PQ, Quach H-L, Thi N-AH, Dinh PC, Duong TN, et al. Transmission of SARS-CoV 2 during long-haul flight. Emerg Infect Dis. 2020;26:2617–24.PubMedCrossRefPubMedCentral Khanh NC, Thai PQ, Quach H-L, Thi N-AH, Dinh PC, Duong TN, et al. Transmission of SARS-CoV 2 during long-haul flight. Emerg Infect Dis. 2020;26:2617–24.PubMedCrossRefPubMedCentral
8.
go back to reference Johansson MA, Quandelacy TM, Kada S, Prasad PV, Steele M, Brooks JT, et al. SARS-CoV-2 Transmission from people without COVID-19 symptoms. JAMA Netw Open. 2021;4:e2035057.PubMedPubMedCentralCrossRef Johansson MA, Quandelacy TM, Kada S, Prasad PV, Steele M, Brooks JT, et al. SARS-CoV-2 Transmission from people without COVID-19 symptoms. JAMA Netw Open. 2021;4:e2035057.PubMedPubMedCentralCrossRef
10.
go back to reference Pan J, Xin L, Ma Y-F, Hu L-H, Li Z-S. Colonoscopy reduces colorectal cancer incidence and mortality in patients with non-malignant findings: a meta-analysis. Am J Gastroenterol. 2016;111:355–65.PubMedPubMedCentralCrossRef Pan J, Xin L, Ma Y-F, Hu L-H, Li Z-S. Colonoscopy reduces colorectal cancer incidence and mortality in patients with non-malignant findings: a meta-analysis. Am J Gastroenterol. 2016;111:355–65.PubMedPubMedCentralCrossRef
12.
go back to reference Kuderer NM, Choueiri TK, Shah DP, Shyr Y, Rubinstein SM, Rivera DR, et al. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study. Lancet. 2020;395:1907–18.PubMedPubMedCentralCrossRef Kuderer NM, Choueiri TK, Shah DP, Shyr Y, Rubinstein SM, Rivera DR, et al. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study. Lancet. 2020;395:1907–18.PubMedPubMedCentralCrossRef
13.
go back to reference Lee LY, Cazier J-B, Angelis V, Arnold R, Bisht V, Campton NA, et al. COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study. Lancet. 2020;395:1919–26.PubMedCentralCrossRefPubMed Lee LY, Cazier J-B, Angelis V, Arnold R, Bisht V, Campton NA, et al. COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study. Lancet. 2020;395:1919–26.PubMedCentralCrossRefPubMed
14.
go back to reference • Saini KS, Tagliamento M, Lambertini M, McNally R, Romano M, Leone M, et al. Mortality in patients with cancer and coronavirus disease 2019: a systematic review and pooled analysis of 52 studies. Eur J Cancer. 2020;139:43–50 Large metanalyses of over 18,650 international cancer patients with COVID-19 reporting a mortality rate of 25.6%.PubMedCentralCrossRefPubMed • Saini KS, Tagliamento M, Lambertini M, McNally R, Romano M, Leone M, et al. Mortality in patients with cancer and coronavirus disease 2019: a systematic review and pooled analysis of 52 studies. Eur J Cancer. 2020;139:43–50 Large metanalyses of over 18,650 international cancer patients with COVID-19 reporting a mortality rate of 25.6%.PubMedCentralCrossRefPubMed
15.
go back to reference Mehta A, Vasudevan S, Parkash A, Sharma A, Vashist T, Krishna V. COVID-19 mortality in cancer patients: a report from a tertiary cancer centre in India. PeerJ. 2021;9:e10599.PubMedCrossRefPubMedCentral Mehta A, Vasudevan S, Parkash A, Sharma A, Vashist T, Krishna V. COVID-19 mortality in cancer patients: a report from a tertiary cancer centre in India. PeerJ. 2021;9:e10599.PubMedCrossRefPubMedCentral
16.
go back to reference Cai G, Gao Y, Zeng S, Yu Y, Liu X, Liu D, et al. Immunological alternation in COVID-19 patients with cancer and its implications on mortality. Oncoimmunology. 2021;10:1854424.PubMedCentralCrossRefPubMed Cai G, Gao Y, Zeng S, Yu Y, Liu X, Liu D, et al. Immunological alternation in COVID-19 patients with cancer and its implications on mortality. Oncoimmunology. 2021;10:1854424.PubMedCentralCrossRefPubMed
17.
go back to reference Fernandes GA, Feriani D, Silva ILAFE, Silva DRME, Arantes PE, da Silva CJ, et al. Differences in mortality of cancer patients with COVID-19 in a Brazilian cancer center. Semin Oncol. 2021;S0093-7754(21):00003–8. Fernandes GA, Feriani D, Silva ILAFE, Silva DRME, Arantes PE, da Silva CJ, et al. Differences in mortality of cancer patients with COVID-19 in a Brazilian cancer center. Semin Oncol. 2021;S0093-7754(21):00003–8.
18.
go back to reference Desai A, Gupta R, Advani S, Ouellette L, Kuderer NM, Lyman GH, et al. Mortality in hospitalized patients with cancer and coronavirus disease 2019: a systematic review and meta-analysis of cohort studies. Cancer. 2020;127:1459–68. Desai A, Gupta R, Advani S, Ouellette L, Kuderer NM, Lyman GH, et al. Mortality in hospitalized patients with cancer and coronavirus disease 2019: a systematic review and meta-analysis of cohort studies. Cancer. 2020;127:1459–68.
19.
go back to reference Giannakoulis VG, Papoutsi E, Siempos II. Effect of cancer on clinical outcomes of patients with COVID- 19: a meta-analysis of patient data. JCO Glob Oncol. 2020;6:799–808. Giannakoulis VG, Papoutsi E, Siempos II. Effect of cancer on clinical outcomes of patients with COVID- 19: a meta-analysis of patient data. JCO Glob Oncol. 2020;6:799–808.
20.
go back to reference Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with cancer appear more vulnerable to SARS-CoV-2: a multicenter study during the COVID-19 outbreak. Cancer Discov. 2020;10:783–91.PubMedPubMedCentral Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with cancer appear more vulnerable to SARS-CoV-2: a multicenter study during the COVID-19 outbreak. Cancer Discov. 2020;10:783–91.PubMedPubMedCentral
21.
go back to reference Wang Q, Berger NA, Xu R. Analyses of risk, racial disparity, and outcomes among US patients with cancer and COVID-19 infection. JAMA Oncol. 2021;7:220.CrossRefPubMed Wang Q, Berger NA, Xu R. Analyses of risk, racial disparity, and outcomes among US patients with cancer and COVID-19 infection. JAMA Oncol. 2021;7:220.CrossRefPubMed
22.
go back to reference Docherty AB, Harrison EM, Green CA, Hardwick HE, Pius R, Norman L, et al. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO clinical characterisation protocol: prospective observational cohort study. BMJ. 2020;369:m1985. Docherty AB, Harrison EM, Green CA, Hardwick HE, Pius R, Norman L, et al. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO clinical characterisation protocol: prospective observational cohort study. BMJ. 2020;369:m1985.
23.
go back to reference Brar G, Pinheiro LC, Shusterman M, Swed B, Reshetnyak E, Soroka O, et al. COVID-19 Severity and outcomes in patients with cancer: a matched cohort study. JCO. 2020;38:3914–24.CrossRef Brar G, Pinheiro LC, Shusterman M, Swed B, Reshetnyak E, Soroka O, et al. COVID-19 Severity and outcomes in patients with cancer: a matched cohort study. JCO. 2020;38:3914–24.CrossRef
24.
go back to reference Tsotra E, Gousis C, Russell B, Moss C, Palmer K, Montes A, et al. COVID-19 infection in gastrointestinal (GI) cancer patients receiving systemic anticancer treatment (SACT) during the outbreak of the pandemic: the Guy’s cancer centre experience. JCO. 2021;39:455.CrossRef Tsotra E, Gousis C, Russell B, Moss C, Palmer K, Montes A, et al. COVID-19 infection in gastrointestinal (GI) cancer patients receiving systemic anticancer treatment (SACT) during the outbreak of the pandemic: the Guy’s cancer centre experience. JCO. 2021;39:455.CrossRef
25.
go back to reference Erdal GS, Polat O, Erdem GU, Korkusuz R, Hindilerden F, Yilmaz M, et al. The mortality rate of COVID-19 was high in cancer patients: a retrospective single-center study. Int J Clin Oncol. 2021;26:826–34. Erdal GS, Polat O, Erdem GU, Korkusuz R, Hindilerden F, Yilmaz M, et al. The mortality rate of COVID-19 was high in cancer patients: a retrospective single-center study. Int J Clin Oncol. 2021;26:826–34.
26.
go back to reference Yang K, Sheng Y, Huang C, Jin Y, Xiong N, Jiang K, et al. Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study. Lancet Oncol. 2020;21:904–13.PubMedCentralCrossRefPubMed Yang K, Sheng Y, Huang C, Jin Y, Xiong N, Jiang K, et al. Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study. Lancet Oncol. 2020;21:904–13.PubMedCentralCrossRefPubMed
28.
go back to reference Garassino MC, Whisenant JG, Huang L-C, Trama A, Torri V, Agustoni F, et al. COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study. Lancet Oncol. 2020;21:914–22.PubMedCentralCrossRefPubMed Garassino MC, Whisenant JG, Huang L-C, Trama A, Torri V, Agustoni F, et al. COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study. Lancet Oncol. 2020;21:914–22.PubMedCentralCrossRefPubMed
29.
go back to reference Lee LYW, Cazier J-B, Starkey T, Briggs SEW, Arnold R, Bisht V, et al. COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study. Lancet Oncol. 2020;21:1309–16.PubMedCentralCrossRefPubMed Lee LYW, Cazier J-B, Starkey T, Briggs SEW, Arnold R, Bisht V, et al. COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study. Lancet Oncol. 2020;21:1309–16.PubMedCentralCrossRefPubMed
30.
go back to reference Tuech J-J, Manceau G, Ouaissi M, Denet C, Chau A, Kartheuser A, et al. Are colorectal cancer patients at risk for COVID-19 infection during the postoperative period? The Covid-GRECCAR study. Int J Color Dis. 2021;36:611–5. Tuech J-J, Manceau G, Ouaissi M, Denet C, Chau A, Kartheuser A, et al. Are colorectal cancer patients at risk for COVID-19 infection during the postoperative period? The Covid-GRECCAR study. Int J Color Dis. 2021;36:611–5.
31.
go back to reference Rana SS. Risk of COVID-19 transmission during gastrointestinal endoscopy. J Dig Endosc. 2020;11:27–30.CrossRef Rana SS. Risk of COVID-19 transmission during gastrointestinal endoscopy. J Dig Endosc. 2020;11:27–30.CrossRef
32.
go back to reference Doubeni CA, Corley DA, Quinn VP, Jensen CD, Zauber AG, Goodman M, et al. Effectiveness of screening colonoscopy in reducing the risk of death from right and left colon cancer: a large community-based study. Gut. 2018;67:291–8.PubMedCrossRef Doubeni CA, Corley DA, Quinn VP, Jensen CD, Zauber AG, Goodman M, et al. Effectiveness of screening colonoscopy in reducing the risk of death from right and left colon cancer: a large community-based study. Gut. 2018;67:291–8.PubMedCrossRef
33.
go back to reference Morris EJA, Goldacre R, Spata E, Mafham M, Finan PJ, Shelton J, et al. Impact of the COVID-19 pandemic on the detection and management of colorectal cancer in England: a population-based study. Lancet Gastroenterol Hepatol. 2021;6:199–208.PubMedPubMedCentralCrossRef Morris EJA, Goldacre R, Spata E, Mafham M, Finan PJ, Shelton J, et al. Impact of the COVID-19 pandemic on the detection and management of colorectal cancer in England: a population-based study. Lancet Gastroenterol Hepatol. 2021;6:199–208.PubMedPubMedCentralCrossRef
34.
go back to reference Rutter MD, Brookes M, Lee TJ, Rogers P, Sharp L. Impact of the COVID-19 pandemic on UK endoscopic activity and cancer detection: a national endoscopy database analysis. Gut. 2021;70:537–43.PubMedCrossRef Rutter MD, Brookes M, Lee TJ, Rogers P, Sharp L. Impact of the COVID-19 pandemic on UK endoscopic activity and cancer detection: a national endoscopy database analysis. Gut. 2021;70:537–43.PubMedCrossRef
35.
go back to reference Kaufman HW, Chen Z, Niles J, Fesko Y. Changes in the number of us patients with newly identified cancer before and during the coronavirus disease 2019 (COVID-19) pandemic. JAMA Netw Open. 2020;3:e2017267.PubMedPubMedCentralCrossRef Kaufman HW, Chen Z, Niles J, Fesko Y. Changes in the number of us patients with newly identified cancer before and during the coronavirus disease 2019 (COVID-19) pandemic. JAMA Netw Open. 2020;3:e2017267.PubMedPubMedCentralCrossRef
36.
go back to reference •• Gawron AJ, Kaltenbach T, Dominitz JA. The impact of the coronavirus disease-19 pandemic on access to endoscopy procedures in the VA healthcare system. Gastroenterology. 2020;159:1216–1220.e1 One of the largest integrated health care systems in the United States, the Veterans Affairs health system, reported dramatic reductions in upper endoscopy and colonoscopies during the COVID-19 pandemic.PubMedCrossRef •• Gawron AJ, Kaltenbach T, Dominitz JA. The impact of the coronavirus disease-19 pandemic on access to endoscopy procedures in the VA healthcare system. Gastroenterology. 2020;159:1216–1220.e1 One of the largest integrated health care systems in the United States, the Veterans Affairs health system, reported dramatic reductions in upper endoscopy and colonoscopies during the COVID-19 pandemic.PubMedCrossRef
37.
go back to reference Meester RGS, Zauber AG, Doubeni CA, Jensen CD, Quinn VP, Helfand M, et al. Consequences of increasing time to colonoscopy examination after positive result from fecal colorectal cancer screening test. Clin Gastroenterol Hepatol. 2016;14:1445–1451.e8.PubMedCentralCrossRefPubMed Meester RGS, Zauber AG, Doubeni CA, Jensen CD, Quinn VP, Helfand M, et al. Consequences of increasing time to colonoscopy examination after positive result from fecal colorectal cancer screening test. Clin Gastroenterol Hepatol. 2016;14:1445–1451.e8.PubMedCentralCrossRefPubMed
38.
go back to reference Degeling K, Baxter NN, Emery J, Franchini F, Gibbs P, Mann GB, et al. An inverse stage-shift model to estimate the excess mortality and health economic impact of delayed access to cancer services due to the COVID-19 pandemic. medRxiv. 2020;2020(05):30.20117630. Degeling K, Baxter NN, Emery J, Franchini F, Gibbs P, Mann GB, et al. An inverse stage-shift model to estimate the excess mortality and health economic impact of delayed access to cancer services due to the COVID-19 pandemic. medRxiv. 2020;2020(05):30.20117630.
40.
go back to reference Perkons N, Kim C, Boedec C, Schneider CJ, Teitelbaum UR, Ben-Josef E, et al. Quantifying the impact of the COVID-19 pandemic on gastrointestinal cancer care delivery. JCO. 2021;39:30.CrossRef Perkons N, Kim C, Boedec C, Schneider CJ, Teitelbaum UR, Ben-Josef E, et al. Quantifying the impact of the COVID-19 pandemic on gastrointestinal cancer care delivery. JCO. 2021;39:30.CrossRef
43.
go back to reference Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2021. CA Cancer J Clin. 2021;71:7–33.PubMedCrossRef Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2021. CA Cancer J Clin. 2021;71:7–33.PubMedCrossRef
44.
go back to reference Siegel RL, Miller KD, Sauer AG, Fedewa SA, Butterly LF, Anderson JC, et al. Colorectal cancer statistics, 2020. CA Cancer J Clin. 2020;70:145–64.PubMedCrossRef Siegel RL, Miller KD, Sauer AG, Fedewa SA, Butterly LF, Anderson JC, et al. Colorectal cancer statistics, 2020. CA Cancer J Clin. 2020;70:145–64.PubMedCrossRef
45.
go back to reference May FP, Almario CV, Ponce N, Spiegel BMR. Racial minorities are more likely than whites to report lack of provider recommendation for colon cancer screening. Am J Gastroenterol. 2015;110:1388–94.PubMedCrossRef May FP, Almario CV, Ponce N, Spiegel BMR. Racial minorities are more likely than whites to report lack of provider recommendation for colon cancer screening. Am J Gastroenterol. 2015;110:1388–94.PubMedCrossRef
46.
go back to reference Warren Andersen S, Blot WJ, Lipworth L, Steinwandel M, Murff HJ, Zheng W. Association of race and socioeconomic status with colorectal cancer screening, colorectal cancer risk, and mortality in southern US adults. JAMA Netw Open. 2019;2:e1917995.PubMedPubMedCentralCrossRef Warren Andersen S, Blot WJ, Lipworth L, Steinwandel M, Murff HJ, Zheng W. Association of race and socioeconomic status with colorectal cancer screening, colorectal cancer risk, and mortality in southern US adults. JAMA Netw Open. 2019;2:e1917995.PubMedPubMedCentralCrossRef
47.
go back to reference Carethers JM, Doubeni CA. Causes of socioeconomic disparities in colorectal cancer and intervention framework and strategies. Gastroenterology. 2020;158:354–67.PubMedCrossRef Carethers JM, Doubeni CA. Causes of socioeconomic disparities in colorectal cancer and intervention framework and strategies. Gastroenterology. 2020;158:354–67.PubMedCrossRef
48.
go back to reference Lopez L, Hart LH, Katz MH. Racial and ethnic health disparities related to COVID-19. JAMA. 2021;325:719.CrossRefPubMed Lopez L, Hart LH, Katz MH. Racial and ethnic health disparities related to COVID-19. JAMA. 2021;325:719.CrossRefPubMed
49.
go back to reference Nodora JN, Gupta S, Howard N, Motadel K, Propst T, Rodriguez J, et al. The COVID-19 pandemic: identify-ing adaptive solutions for colorectal cancer screening in underserved communities. J Natl Cancer Inst. 2020:djaa117. Nodora JN, Gupta S, Howard N, Motadel K, Propst T, Rodriguez J, et al. The COVID-19 pandemic: identify-ing adaptive solutions for colorectal cancer screening in underserved communities. J Natl Cancer Inst. 2020:djaa117.
50.
go back to reference Balzora S, Issaka RB, Anyane-Yeboa A, Gray DM, May FP. Impact of COVID-19 on colorectal cancer disparities and the way forward. Gastrointest Endosc. 2020;92:946–50.PubMedCentralCrossRefPubMed Balzora S, Issaka RB, Anyane-Yeboa A, Gray DM, May FP. Impact of COVID-19 on colorectal cancer disparities and the way forward. Gastrointest Endosc. 2020;92:946–50.PubMedCentralCrossRefPubMed
51.
go back to reference Wolf AMD, Fontham ETH, Church TR, Flowers CR, Guerra CE, LaMonte SJ, et al. Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society. CA Cancer J Clin. 2018;68:250–81.CrossRefPubMed Wolf AMD, Fontham ETH, Church TR, Flowers CR, Guerra CE, LaMonte SJ, et al. Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society. CA Cancer J Clin. 2018;68:250–81.CrossRefPubMed
52.
go back to reference US Preventive Services Task Force, Davidson KW, Barry MJ, Mangione CM, Cabana M, Caughey AB, et al. Screening for colorectal cancer: US preventive services task force recommendation statement. JAMA. 2021;325:1965.CrossRef US Preventive Services Task Force, Davidson KW, Barry MJ, Mangione CM, Cabana M, Caughey AB, et al. Screening for colorectal cancer: US preventive services task force recommendation statement. JAMA. 2021;325:1965.CrossRef
53.
go back to reference Shah MA, Emlen MF, Shore T, Mayer S, Leonard JP, Rossi A, et al. Hematology and oncology clinical care during the coronavirus disease 2019 pandemic. CA Cancer J Clin. 2020;70:349–54. Shah MA, Emlen MF, Shore T, Mayer S, Leonard JP, Rossi A, et al. Hematology and oncology clinical care during the coronavirus disease 2019 pandemic. CA Cancer J Clin. 2020;70:349–54.
54.
go back to reference Kamposioras K, Lim KHJ, Saunders MP, Marti K, Anderson D, Cutting M, et al. The impact of changes in service delivery in patients with colorectal cancer during the first peak of the COVID-19 pandemic. JCO. 2021;39:28. Kamposioras K, Lim KHJ, Saunders MP, Marti K, Anderson D, Cutting M, et al. The impact of changes in service delivery in patients with colorectal cancer during the first peak of the COVID-19 pandemic. JCO. 2021;39:28.
55.
go back to reference Garcia R, Dwyer A, McDonnell M. Understanding the impact of COVID-19 on the colorectal cancer community: barriers and opportunities for care. JCO. 2021;39:29. Garcia R, Dwyer A, McDonnell M. Understanding the impact of COVID-19 on the colorectal cancer community: barriers and opportunities for care. JCO. 2021;39:29.
56.
go back to reference Jiang CY, El-Kouri NT, Elliot D, Shields J, Caram MEV, Frankel TL, et al. Telehealth for cancer care in veterans: opportunities and challenges revealed by COVID. JCO Oncol Pract. 2020;17:22–9. Jiang CY, El-Kouri NT, Elliot D, Shields J, Caram MEV, Frankel TL, et al. Telehealth for cancer care in veterans: opportunities and challenges revealed by COVID. JCO Oncol Pract. 2020;17:22–9.
58.
go back to reference Marshall JL, Yarden RI, Weinberg BA. Colorectal cancer care in the age of coronavirus: strategies to reduce risk and maintain benefit. Colorectal Cancer. 2020;9:1. Marshall JL, Yarden RI, Weinberg BA. Colorectal cancer care in the age of coronavirus: strategies to reduce risk and maintain benefit. Colorectal Cancer. 2020;9:1.
59.
go back to reference •• O’Leary MP, Choong KC, Thornblade LW, Fakih MG, Fong Y, Kaiser AM. Management Considerations for the Surgical Treatment of Colorectal Cancer During the Global Covid-19 Pandemic. Ann Surg. 2020;272:e98–105 Expert recommendations in colon cancer surgical management during the COVID-19 pandemic.CrossRefPubMed •• O’Leary MP, Choong KC, Thornblade LW, Fakih MG, Fong Y, Kaiser AM. Management Considerations for the Surgical Treatment of Colorectal Cancer During the Global Covid-19 Pandemic. Ann Surg. 2020;272:e98–105 Expert recommendations in colon cancer surgical management during the COVID-19 pandemic.CrossRefPubMed
60.
go back to reference •• Lou E, Beg S, Bergsland E, Eng C, Khorana A, Kopetz S, et al. Modifying practices in GI oncology in the face of COVID-19: recommendations from expert oncologists on minimizing patient risk. JCO Oncol Pract. 2020;16:383–8 Expert comprehensive recommendations in colon cancer management during the COVID-19 pandemic.CrossRefPubMed •• Lou E, Beg S, Bergsland E, Eng C, Khorana A, Kopetz S, et al. Modifying practices in GI oncology in the face of COVID-19: recommendations from expert oncologists on minimizing patient risk. JCO Oncol Pract. 2020;16:383–8 Expert comprehensive recommendations in colon cancer management during the COVID-19 pandemic.CrossRefPubMed
61.
go back to reference Vecchione L, Stintzing S, Pentheroudakis G, Douillard J-Y, Lordick F. ESMO management and treatment adapted recommendations in the COVID-19 era: colorectal cancer. ESMO Open. 2020;5:e000826.CrossRefPubMed Vecchione L, Stintzing S, Pentheroudakis G, Douillard J-Y, Lordick F. ESMO management and treatment adapted recommendations in the COVID-19 era: colorectal cancer. ESMO Open. 2020;5:e000826.CrossRefPubMed
62.
go back to reference Skowron KB, Hurst RD, Umanskiy K, Hyman NH, Shogan BD. Caring for patients with rectal cancer during the COVID-19 pandemic. J Gastrointest Surg. 2020;24:1698–703. Skowron KB, Hurst RD, Umanskiy K, Hyman NH, Shogan BD. Caring for patients with rectal cancer during the COVID-19 pandemic. J Gastrointest Surg. 2020;24:1698–703.
63.
go back to reference Marijnen CAM, Peters FP, Rödel C, Bujko K, Haustermans K, Fokas E, et al. International expert consensus statement regarding radiotherapy treatment options for rectal cancer during the COVID 19 pandemic. Radiother Oncol. 2020;148:213–5.CrossRefPubMedPubMedCentral Marijnen CAM, Peters FP, Rödel C, Bujko K, Haustermans K, Fokas E, et al. International expert consensus statement regarding radiotherapy treatment options for rectal cancer during the COVID 19 pandemic. Radiother Oncol. 2020;148:213–5.CrossRefPubMedPubMedCentral
64.
go back to reference Aguado C, García-Paredes B, Sotelo MJ, Sastre J, Díaz-Rubio E. Should capecitabine replace 5-fluorouracil in the first-line treatment of metastatic colorectal cancer? World J Gastroenterol. 2014;20:6092–101.PubMedCentralCrossRefPubMed Aguado C, García-Paredes B, Sotelo MJ, Sastre J, Díaz-Rubio E. Should capecitabine replace 5-fluorouracil in the first-line treatment of metastatic colorectal cancer? World J Gastroenterol. 2014;20:6092–101.PubMedCentralCrossRefPubMed
65.
go back to reference Sun JF, Wu RR, Norris C, Noone A-M, Amankwa-Sakyi M, Slack R, et al. Safety of chronic low-dose capecitabine as maintenance therapy in gastrointestinal cancers. Gastrointest Cancer Res. 2009;3:134–40.PubMedPubMedCentral Sun JF, Wu RR, Norris C, Noone A-M, Amankwa-Sakyi M, Slack R, et al. Safety of chronic low-dose capecitabine as maintenance therapy in gastrointestinal cancers. Gastrointest Cancer Res. 2009;3:134–40.PubMedPubMedCentral
66.
go back to reference Bryson E, Sakach E, Patel U, Watson M, Hall K, Draper A, et al. Safety and efficacy of 7 days on/7 days off versus 14 days on/7 days off schedules of capecitabine in patients with metastatic colorectal cancer: a retrospective review. Clin Colorectal Cancer. 2021;20:153–60. Bryson E, Sakach E, Patel U, Watson M, Hall K, Draper A, et al. Safety and efficacy of 7 days on/7 days off versus 14 days on/7 days off schedules of capecitabine in patients with metastatic colorectal cancer: a retrospective review. Clin Colorectal Cancer. 2021;20:153–60.
67.
go back to reference Falcone A, Ricci S, Brunetti I, Pfanner E, Allegrini G, Barbara C, et al. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. J Clin Oncol. 2007;25:1670–6.CrossRefPubMed Falcone A, Ricci S, Brunetti I, Pfanner E, Allegrini G, Barbara C, et al. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. J Clin Oncol. 2007;25:1670–6.CrossRefPubMed
68.
go back to reference Mayer RJ, Van Cutsem E, Falcone A, Yoshino T, Garcia-Carbonero R, Mizunuma N, et al. Randomized trial of TAS-102 for refractory metastatic colorectal cancer. N Engl J Med. 2015;372:1909–19.CrossRefPubMed Mayer RJ, Van Cutsem E, Falcone A, Yoshino T, Garcia-Carbonero R, Mizunuma N, et al. Randomized trial of TAS-102 for refractory metastatic colorectal cancer. N Engl J Med. 2015;372:1909–19.CrossRefPubMed
69.
go back to reference Long GV, Tykodi SS, Schneider JG, Garbe C, Gravis G, Rashford M, et al. Assessment of nivolumab exposure and clinical safety of 480 mg every 4 weeks flat-dosing schedule in patients with cancer. Ann Oncol. 2018;29:2208–13.PubMedCentralCrossRefPubMed Long GV, Tykodi SS, Schneider JG, Garbe C, Gravis G, Rashford M, et al. Assessment of nivolumab exposure and clinical safety of 480 mg every 4 weeks flat-dosing schedule in patients with cancer. Ann Oncol. 2018;29:2208–13.PubMedCentralCrossRefPubMed
70.
go back to reference Lala M, Akala O, Chartash E, Kalabis M, Su S-C, de Alwis D, et al. Abstract CT042: pembrolizumab 400 mg Q6W dosing: first clinical outcomes data from keynote-555 cohort B in metastatic melanoma patients. Cancer Res. 2020;80:CT042. Lala M, Akala O, Chartash E, Kalabis M, Su S-C, de Alwis D, et al. Abstract CT042: pembrolizumab 400 mg Q6W dosing: first clinical outcomes data from keynote-555 cohort B in metastatic melanoma patients. Cancer Res. 2020;80:CT042.
71.
go back to reference Yoshida Y, Hasegawa J, Nezu R, Mikata S, Kim Y, Nishimura J, et al. Clinical significance of bolus 5-fluorouracil for recurrent or metastatic colorectal cancer treated with FOLFOX therapy. JCO. 2010;28:e14078.CrossRef Yoshida Y, Hasegawa J, Nezu R, Mikata S, Kim Y, Nishimura J, et al. Clinical significance of bolus 5-fluorouracil for recurrent or metastatic colorectal cancer treated with FOLFOX therapy. JCO. 2010;28:e14078.CrossRef
72.
go back to reference Hochster HS, Grothey A, Hart L, Rowland K, Ansari R, Alberts S, et al. Improved time to treatment failure with an intermittent oxaliplatin strategy: results of CONcePT. Ann Oncol. 2014;25:1172–8.PubMedPubMedCentralCrossRef Hochster HS, Grothey A, Hart L, Rowland K, Ansari R, Alberts S, et al. Improved time to treatment failure with an intermittent oxaliplatin strategy: results of CONcePT. Ann Oncol. 2014;25:1172–8.PubMedPubMedCentralCrossRef
73.
go back to reference Maindrault-Goebel F, Lledo G, Chibaudel B, Mineur L, Andre T, Bennamoun M, et al. Final results of OPTIMOX2, a large randomized phase II study of maintenance therapy or chemotherapy-free intervals (CFI) after FOLFOX in patients with metastatic colorectal cancer (MRC): A GERCOR study. JCO. 2007;25:4013.CrossRef Maindrault-Goebel F, Lledo G, Chibaudel B, Mineur L, Andre T, Bennamoun M, et al. Final results of OPTIMOX2, a large randomized phase II study of maintenance therapy or chemotherapy-free intervals (CFI) after FOLFOX in patients with metastatic colorectal cancer (MRC): A GERCOR study. JCO. 2007;25:4013.CrossRef
74.
go back to reference Simkens LHJ, van Tinteren H, Punt CJA, Koopman M. Maintenance treatment in metastatic colorectal cancer. Lancet Oncol. 2015;16:e582–3.PubMedCrossRef Simkens LHJ, van Tinteren H, Punt CJA, Koopman M. Maintenance treatment in metastatic colorectal cancer. Lancet Oncol. 2015;16:e582–3.PubMedCrossRef
75.
go back to reference Kannarkatt J, Joseph J, Kurniali PC, Al-Janadi A, Hrinczenko B. Adjuvant chemotherapy for stage ii colon cancer: a clinical dilemma. JOP. 2017;13:233–41.PubMedCrossRef Kannarkatt J, Joseph J, Kurniali PC, Al-Janadi A, Hrinczenko B. Adjuvant chemotherapy for stage ii colon cancer: a clinical dilemma. JOP. 2017;13:233–41.PubMedCrossRef
76.
go back to reference Tournigand C, André T, Bonnetain F, Chibaudel B, Lledo G, Hickish T, et al. Adjuvant therapy with fluorouracil and oxaliplatin in stage ii and elderly patients (between ages 70 and 75 years) with colon cancer: subgroup analyses of the multicenter international study of oxaliplatin, fluorouracil, and leucovorin in the adjuvant treatment of colon cancer trial. JCO. 2012;30:3353–60.CrossRef Tournigand C, André T, Bonnetain F, Chibaudel B, Lledo G, Hickish T, et al. Adjuvant therapy with fluorouracil and oxaliplatin in stage ii and elderly patients (between ages 70 and 75 years) with colon cancer: subgroup analyses of the multicenter international study of oxaliplatin, fluorouracil, and leucovorin in the adjuvant treatment of colon cancer trial. JCO. 2012;30:3353–60.CrossRef
77.
go back to reference •• André T, Meyerhardt J, Iveson T, Sobrero A, Yoshino T, Souglakos I, et al. Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials. Lancet Oncol. 2020;21:1620–9 Prospective, pooled analysis of 6 randomized phase III trials failed to demonstrate non-inferiority of 3 months versus 6 months of adjuvant FOLFOX or CAPOX in stage III colorectal cancers. However, the absolute difference in 5-year overall survival was only 0.4% and survival data combined with reduced toxicities supported 3 months of adjuvant CAPOX use in most patients.PubMedCrossRefPubMedCentral •• André T, Meyerhardt J, Iveson T, Sobrero A, Yoshino T, Souglakos I, et al. Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials. Lancet Oncol. 2020;21:1620–9 Prospective, pooled analysis of 6 randomized phase III trials failed to demonstrate non-inferiority of 3 months versus 6 months of adjuvant FOLFOX or CAPOX in stage III colorectal cancers. However, the absolute difference in 5-year overall survival was only 0.4% and survival data combined with reduced toxicities supported 3 months of adjuvant CAPOX use in most patients.PubMedCrossRefPubMedCentral
78.
go back to reference Sun L, Xu Y, Zhang T, Yang Y. Impact of the COVID-19 outbreak on adjuvant chemotherapy for patients with stage II or III colon cancer: experiences from a multicentre clinical trial in China. Curr Oncol. 2020;27:159–62.PubMedPubMedCentralCrossRef Sun L, Xu Y, Zhang T, Yang Y. Impact of the COVID-19 outbreak on adjuvant chemotherapy for patients with stage II or III colon cancer: experiences from a multicentre clinical trial in China. Curr Oncol. 2020;27:159–62.PubMedPubMedCentralCrossRef
79.
go back to reference Power R, O’Donohoe C, Enright C, Glennon L, McDowell L, Gallagher DJ, et al. Analysis of systemic therapy delivery for gastrointestinal cancer patients during the COVID-19 pandemic. JCO. 2020;38:301.CrossRef Power R, O’Donohoe C, Enright C, Glennon L, McDowell L, Gallagher DJ, et al. Analysis of systemic therapy delivery for gastrointestinal cancer patients during the COVID-19 pandemic. JCO. 2020;38:301.CrossRef
80.
go back to reference Baxter MA, Murphy J, Cameron D, Jordan J, Crearie C, Lilley C, et al. The impact of COVID-19 on systemic anticancer treatment delivery in Scotland. Br J Cancer. 2021;124:1353–6.PubMedCentralCrossRefPubMed Baxter MA, Murphy J, Cameron D, Jordan J, Crearie C, Lilley C, et al. The impact of COVID-19 on systemic anticancer treatment delivery in Scotland. Br J Cancer. 2021;124:1353–6.PubMedCentralCrossRefPubMed
82.
go back to reference Mowery YM, Salama JK, Zafar SY, Moore HG, Willett CG, Czito BG, et al. Neoadjuvant long-course chemoradiation remains strongly favored over short-course radiotherapy by radiation oncologists in the United States. Cancer. 2017;123:1434–41.PubMedCrossRef Mowery YM, Salama JK, Zafar SY, Moore HG, Willett CG, Czito BG, et al. Neoadjuvant long-course chemoradiation remains strongly favored over short-course radiotherapy by radiation oncologists in the United States. Cancer. 2017;123:1434–41.PubMedCrossRef
83.
go back to reference Erlandsson J, Holm T, Pettersson D, Berglund Å, Cedermark B, Radu C, et al. Optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer (Stockholm III): a multicentre, randomised, non-blinded, phase 3, non-inferiority trial. Lancet Oncol. 2017;18:336–46.PubMedCrossRef Erlandsson J, Holm T, Pettersson D, Berglund Å, Cedermark B, Radu C, et al. Optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer (Stockholm III): a multicentre, randomised, non-blinded, phase 3, non-inferiority trial. Lancet Oncol. 2017;18:336–46.PubMedCrossRef
84.
go back to reference Ngan SY, Burmeister B, Fisher RJ, Solomon M, Goldstein D, Joseph D, et al. randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: Trans-Tasman Radiation Oncology Group Trial 01.04. JCO. 2012;30:3827–33.CrossRef Ngan SY, Burmeister B, Fisher RJ, Solomon M, Goldstein D, Joseph D, et al. randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: Trans-Tasman Radiation Oncology Group Trial 01.04. JCO. 2012;30:3827–33.CrossRef
85.
go back to reference Bujko K, Nowacki MP, Nasierowska-Guttmejer A, Michalski W, Bebenek M, Pudełko M, et al. Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy. Radiother Oncol. 2004;72:15–24.PubMedCrossRef Bujko K, Nowacki MP, Nasierowska-Guttmejer A, Michalski W, Bebenek M, Pudełko M, et al. Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy. Radiother Oncol. 2004;72:15–24.PubMedCrossRef
86.
go back to reference Dutta SW, Alonso CE, Jones TC, Waddle MR, Janowski E-M, Trifiletti DM. Short-course versus long-course neoadjuvant therapy for non-metastatic rectal cancer: patterns of care and outcomes from the national cancer database. Clin Colorectal Cancer. 2018;17:297–306.CrossRefPubMed Dutta SW, Alonso CE, Jones TC, Waddle MR, Janowski E-M, Trifiletti DM. Short-course versus long-course neoadjuvant therapy for non-metastatic rectal cancer: patterns of care and outcomes from the national cancer database. Clin Colorectal Cancer. 2018;17:297–306.CrossRefPubMed
87.
go back to reference Bujko K, Partycki M, Pietrzak L. Neoadjuvant radiotherapy (5 × 5 Gy): immediate versus delayed surgery. Recent Results Cancer Res. 2014;203:171–87.CrossRefPubMed Bujko K, Partycki M, Pietrzak L. Neoadjuvant radiotherapy (5 × 5 Gy): immediate versus delayed surgery. Recent Results Cancer Res. 2014;203:171–87.CrossRefPubMed
88.
go back to reference Lefèvre JH, Mineur L, Cachanado M, Denost Q, Rouanet P, de Chaisemartin C, et al. Does A longer waiting period after neoadjuvant radio-chemotherapy improve the oncological prognosis of rectal cancer?: three years’ follow-up results of the greccar-6 randomized multicenter trial. Ann Surg. 2019;270:747–54.CrossRefPubMed Lefèvre JH, Mineur L, Cachanado M, Denost Q, Rouanet P, de Chaisemartin C, et al. Does A longer waiting period after neoadjuvant radio-chemotherapy improve the oncological prognosis of rectal cancer?: three years’ follow-up results of the greccar-6 randomized multicenter trial. Ann Surg. 2019;270:747–54.CrossRefPubMed
89.
go back to reference • Hospers G, Bahadoer RR, Dijkstra EA, van Etten B, Marijnen C, Putter H, et al. Short-course radiotherapy followed by chemotherapy before TME in locally advanced rectal cancer: The randomized RAPIDO trial. JCO. 2020;38:4006 This prospective phase III trial in high risk locally advanced rectal cancers found adding neoadjuvant chemotherapy to neoadjuvant chemoradiation resulted in statistically significant higher complete response rates and lower rates of distant metastases compared to the standard practice of neoadjuvant chemoradiation and optional adjuvant chemotherapy.CrossRef • Hospers G, Bahadoer RR, Dijkstra EA, van Etten B, Marijnen C, Putter H, et al. Short-course radiotherapy followed by chemotherapy before TME in locally advanced rectal cancer: The randomized RAPIDO trial. JCO. 2020;38:4006 This prospective phase III trial in high risk locally advanced rectal cancers found adding neoadjuvant chemotherapy to neoadjuvant chemoradiation resulted in statistically significant higher complete response rates and lower rates of distant metastases compared to the standard practice of neoadjuvant chemoradiation and optional adjuvant chemotherapy.CrossRef
90.
go back to reference Lin Z, Cai M, Zhang P, Li X, Cai K, Nie X, et al. Short-course radiotherapy and subsequent CAPOX plus camrelizumab followed by delayed surgery for locally advanced rectal cancer: Short-term results of a phase II trial. JCO. 2021;39:63.CrossRef Lin Z, Cai M, Zhang P, Li X, Cai K, Nie X, et al. Short-course radiotherapy and subsequent CAPOX plus camrelizumab followed by delayed surgery for locally advanced rectal cancer: Short-term results of a phase II trial. JCO. 2021;39:63.CrossRef
91.
go back to reference Felice FD, Petrucciani N. Treatment approach in locally advanced rectal cancer during coronavirus (COVID-19) pandemic: long course or short course? Color Dis. 2020;22:642–3.CrossRef Felice FD, Petrucciani N. Treatment approach in locally advanced rectal cancer during coronavirus (COVID-19) pandemic: long course or short course? Color Dis. 2020;22:642–3.CrossRef
92.
go back to reference Romesser PB, Wu AJ, Cercek A, Smith JJ, Weiser M, Saltz L, et al. Management of locally advanced rectal cancer during the covid-19 pandemic: a necessary paradigm change at Memorial Sloan Kettering Cancer Center. Adv Radiat Oncol. 2020;5:687–9.PubMedCentralCrossRefPubMed Romesser PB, Wu AJ, Cercek A, Smith JJ, Weiser M, Saltz L, et al. Management of locally advanced rectal cancer during the covid-19 pandemic: a necessary paradigm change at Memorial Sloan Kettering Cancer Center. Adv Radiat Oncol. 2020;5:687–9.PubMedCentralCrossRefPubMed
94.
go back to reference Doglietto F, Vezzoli M, Gheza F, Lussardi GL, Domenicucci M, Vecchiarelli L, et al. Factors associated with surgical mortality and complications among patients with and without coronavirus disease 2019 (COVID-19) in Italy. JAMA Surg. 2020;155:691.CrossRefPubMed Doglietto F, Vezzoli M, Gheza F, Lussardi GL, Domenicucci M, Vecchiarelli L, et al. Factors associated with surgical mortality and complications among patients with and without coronavirus disease 2019 (COVID-19) in Italy. JAMA Surg. 2020;155:691.CrossRefPubMed
95.
go back to reference Abate SM, Mantefardo B, Basu B. Postoperative mortality among surgical patients with COVID-19: a systematic review and meta-analysis. Patient Saf Surg. 2020;14:37.PubMedCentralCrossRefPubMed Abate SM, Mantefardo B, Basu B. Postoperative mortality among surgical patients with COVID-19: a systematic review and meta-analysis. Patient Saf Surg. 2020;14:37.PubMedCentralCrossRefPubMed
96.
go back to reference Spinelli A, Carvello M, Carrano FM, Pasini F, Foppa C, Taffurelli G, et al. Reduced length of stay after 1057 elective colorectal surgery during the peak phase of 1058 Covid-19 pandemic: a positive effect of infection risk awareness? Surgery. 2020;20:30852–7. Spinelli A, Carvello M, Carrano FM, Pasini F, Foppa C, Taffurelli G, et al. Reduced length of stay after 1057 elective colorectal surgery during the peak phase of 1058 Covid-19 pandemic: a positive effect of infection risk awareness? Surgery. 2020;20:30852–7.
97.
go back to reference Grass F, Behm KT, Duchalais E, Crippa J, Spears GM, Harmsen WS, et al. Impact of delay to surgery on survival in stage I-III colon cancer. Eur J Surg Oncol. 2020;46:455–61.CrossRefPubMed Grass F, Behm KT, Duchalais E, Crippa J, Spears GM, Harmsen WS, et al. Impact of delay to surgery on survival in stage I-III colon cancer. Eur J Surg Oncol. 2020;46:455–61.CrossRefPubMed
98.
go back to reference Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier P, et al. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet. 2008;371:1007–16.PubMedPubMedCentralCrossRef Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier P, et al. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet. 2008;371:1007–16.PubMedPubMedCentralCrossRef
99.
go back to reference Santoro GA, Grossi U, Murad-Regadas S, Nunoo-Mensah JW, Mellgren A, Di Tanna GL, et al. DElayed COloRectal cancer care during COVID-19 Pandemic (DECOR-19): global perspective from an international survey. Surgery. 2021;169:796–807.CrossRefPubMed Santoro GA, Grossi U, Murad-Regadas S, Nunoo-Mensah JW, Mellgren A, Di Tanna GL, et al. DElayed COloRectal cancer care during COVID-19 Pandemic (DECOR-19): global perspective from an international survey. Surgery. 2021;169:796–807.CrossRefPubMed
100.
go back to reference Larson DW, Aziz MAAE, Mandrekar JN. How many lives will delay of colon cancer surgery cost during the COVID-19 pandemic? An analysis based on the US national cancer database. Mayo Clin Proc. 2020;95:1805–7.CrossRefPubMed Larson DW, Aziz MAAE, Mandrekar JN. How many lives will delay of colon cancer surgery cost during the COVID-19 pandemic? An analysis based on the US national cancer database. Mayo Clin Proc. 2020;95:1805–7.CrossRefPubMed
103.
105.
go back to reference Gottlieb RL, Nirula A, Chen P, Boscia J, Heller B, Morris J, et al. Effect of bamlanivimab as monotherapy or in combination with etesevimab on viral load in patients with mild to moderate COVID-19: a randomized clinical trial. JAMA. 2021;325:632.CrossRefPubMedPubMedCentral Gottlieb RL, Nirula A, Chen P, Boscia J, Heller B, Morris J, et al. Effect of bamlanivimab as monotherapy or in combination with etesevimab on viral load in patients with mild to moderate COVID-19: a randomized clinical trial. JAMA. 2021;325:632.CrossRefPubMedPubMedCentral
106.
go back to reference Chen P, Nirula A, Heller B, Gottlieb RL, Boscia J, Morris J, et al. SARS-CoV-2 neutralizing antibody LY-CoV555 in outpatients with Covid-19. N Engl J Med. 2021;384:229–37.CrossRefPubMed Chen P, Nirula A, Heller B, Gottlieb RL, Boscia J, Morris J, et al. SARS-CoV-2 neutralizing antibody LY-CoV555 in outpatients with Covid-19. N Engl J Med. 2021;384:229–37.CrossRefPubMed
107.
go back to reference An EUA for bamlanivimab—a monoclonal antibody for COVID-19. JAMA. 2021;325:880. An EUA for bamlanivimab—a monoclonal antibody for COVID-19. JAMA. 2021;325:880.
109.
go back to reference Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, et al. Remdesivir for the treatment of Covid-19 — final report. N Engl J Med. 2020;383:1813–26.CrossRefPubMed Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, et al. Remdesivir for the treatment of Covid-19 — final report. N Engl J Med. 2020;383:1813–26.CrossRefPubMed
110.
go back to reference van Paassen J, Vos JS, Hoekstra EM, Neumann KMI, Boot PC, Arbous SM. Corticosteroid use in COVID-19 patients: a systematic review and meta-analysis on clinical outcomes. Crit Care. 2020;24:696.PubMedPubMedCentralCrossRef van Paassen J, Vos JS, Hoekstra EM, Neumann KMI, Boot PC, Arbous SM. Corticosteroid use in COVID-19 patients: a systematic review and meta-analysis on clinical outcomes. Crit Care. 2020;24:696.PubMedPubMedCentralCrossRef
111.
go back to reference The RECOVERY Collaborative Group. Dexamethasone in hospitalized patients with Covid-19. N Engl J Med. 2021;384:693–704.CrossRef The RECOVERY Collaborative Group. Dexamethasone in hospitalized patients with Covid-19. N Engl J Med. 2021;384:693–704.CrossRef
112.
go back to reference Kalil AC, Patterson TF, Mehta AK, Tomashek KM, Wolfe CR, Ghazaryan V, et al. Baricitinib plus remdesivir for hospitalized adults with Covid-19. N Engl J Med. 2021;384:795–807.PubMedCrossRef Kalil AC, Patterson TF, Mehta AK, Tomashek KM, Wolfe CR, Ghazaryan V, et al. Baricitinib plus remdesivir for hospitalized adults with Covid-19. N Engl J Med. 2021;384:795–807.PubMedCrossRef
113.
go back to reference Honjo K, Russell RM, Li R, Liu W, Stoltz R, Tabengwa EM, et al. Convalescent plasma-mediated resolution of COVID-19 in a patient with humoral immunodeficiency. Cell Rep Med. 2021;2:100164.PubMedCrossRef Honjo K, Russell RM, Li R, Liu W, Stoltz R, Tabengwa EM, et al. Convalescent plasma-mediated resolution of COVID-19 in a patient with humoral immunodeficiency. Cell Rep Med. 2021;2:100164.PubMedCrossRef
114.
go back to reference Hueso T, Pouderoux C, Péré H, Beaumont A-L, Raillon L-A, Ader F, et al. Convalescent plasma therapy for B-cell-depleted patients with protracted COVID-19. Blood. 2020;136:2290–5.CrossRefPubMed Hueso T, Pouderoux C, Péré H, Beaumont A-L, Raillon L-A, Ader F, et al. Convalescent plasma therapy for B-cell-depleted patients with protracted COVID-19. Blood. 2020;136:2290–5.CrossRefPubMed
115.
go back to reference Taplitz RA, Kennedy EB, Bow EJ, Crews J, Gleason C, Hawley DK, et al. Outpatient management of fever and neutropenia in adults treated for malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update. J Clin Oncol. 2018;36:1443–53.PubMedCrossRef Taplitz RA, Kennedy EB, Bow EJ, Crews J, Gleason C, Hawley DK, et al. Outpatient management of fever and neutropenia in adults treated for malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update. J Clin Oncol. 2018;36:1443–53.PubMedCrossRef
116.
go back to reference Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in Wuhan, China. Clin Infect Dis. 2020;71:762–8.PubMedCrossRef Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in Wuhan, China. Clin Infect Dis. 2020;71:762–8.PubMedCrossRef
117.
go back to reference Taha M, Sharma A, Soubani A. Clinical deterioration during neutropenia recovery after G-CSF therapy in patient with COVID-19. Respir Med Case Rep. 2020;31:101231.PubMedPubMedCentral Taha M, Sharma A, Soubani A. Clinical deterioration during neutropenia recovery after G-CSF therapy in patient with COVID-19. Respir​ Med Case Rep. 2020;31:101231.PubMedPubMedCentral
118.
go back to reference Nawar T, Morjaria S, Kaltsas A, Patel D, Perez-Johnston R, Daniyan AF, et al. Granulocyte-colony stimulating factor in COVID-19: is it stimulating more than just the bone marrow? Am J Hematol. 2020;95:E210–3.PubMedCrossRef Nawar T, Morjaria S, Kaltsas A, Patel D, Perez-Johnston R, Daniyan AF, et al. Granulocyte-colony stimulating factor in COVID-19: is it stimulating more than just the bone marrow? Am J Hematol. 2020;95:E210–3.PubMedCrossRef
120.
go back to reference Sadoff J, Le Gars M, Shukarev G, Heerwegh D, Truyers C, de Groot AM, et al. Interim results of a phase 1–2a trial of Ad26.COV2.S Covid-19 vaccine. N Engl J Med. 2021;384:1824–35. Sadoff J, Le Gars M, Shukarev G, Heerwegh D, Truyers C, de Groot AM, et al. Interim results of a phase 1–2a trial of Ad26.COV2.S Covid-19 vaccine. N Engl J Med. 2021;384:1824–35.
121.
go back to reference Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R, et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med. 2021;384:403–16.PubMedCrossRef Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R, et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med. 2021;384:403–16.PubMedCrossRef
122.
go back to reference Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 2020;383:2603–15.PubMedCrossRef Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 2020;383:2603–15.PubMedCrossRef
123.
go back to reference Blanchette PS, Chung H, Pritchard KI, Earle CC, Campitelli MA, Buchan SA, et al. Influenza Vaccine effectiveness among patients with cancer: a population-based study using health administrative and laboratory testing data from Ontario, Canada. JCO. 2019;37:2795–804.CrossRef Blanchette PS, Chung H, Pritchard KI, Earle CC, Campitelli MA, Buchan SA, et al. Influenza Vaccine effectiveness among patients with cancer: a population-based study using health administrative and laboratory testing data from Ontario, Canada. JCO. 2019;37:2795–804.CrossRef
124.
125.
go back to reference Rubin LG, Levin MJ, Ljungman P, Davies EG, Avery R, Tomblyn M, et al. 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host. Clin Infect Dis. 2014;58:e44–100.PubMedCrossRef Rubin LG, Levin MJ, Ljungman P, Davies EG, Avery R, Tomblyn M, et al. 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host. Clin Infect Dis. 2014;58:e44–100.PubMedCrossRef
126.
go back to reference Keam B, Kim M-K, Choi Y, Choi S-J, Choe PG, Lee K-H, et al. Optimal timing of influenza vaccination during 3-week cytotoxic chemotherapy cycles. Cancer. 2017;123:841–8.CrossRefPubMed Keam B, Kim M-K, Choi Y, Choi S-J, Choe PG, Lee K-H, et al. Optimal timing of influenza vaccination during 3-week cytotoxic chemotherapy cycles. Cancer. 2017;123:841–8.CrossRefPubMed
127.
go back to reference Desai A, Gainor JF, Hegde A, Schram AM, Curigliano G, Pal S, et al. COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials. Nat Rev Clin Oncol. 2021;18:313–9. Desai A, Gainor JF, Hegde A, Schram AM, Curigliano G, Pal S, et al. COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials. Nat Rev Clin Oncol. 2021;18:313–9.
129.
go back to reference van der Veldt AAM, Oosting SF, Dingemans A-MC, Fehrmann RSN, Geurtsvan Kessel C, Jalving M, et al. COVID-19 vaccination: the VOICE for patients with cancer. Nat Med. 2021;27:568–9. van der Veldt AAM, Oosting SF, Dingemans A-MC, Fehrmann RSN, Geurtsvan Kessel C, Jalving M, et al. COVID-19 vaccination: the VOICE for patients with cancer. Nat Med. 2021;27:568–9.
Metadata
Title
Lessons Learned in Managing Patients with Colorectal Cancer During the COVID-19 Pandemic
Authors
Reetu Mukherji, MD
John L. Marshall, MD
Publication date
01-10-2021
Publisher
Springer US
Published in
Current Treatment Options in Oncology / Issue 10/2021
Print ISSN: 1527-2729
Electronic ISSN: 1534-6277
DOI
https://doi.org/10.1007/s11864-021-00888-3

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