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01-06-2020 | Rectal Cancer | Original Article

Delayed surgery after radio-chemotherapy for rectal adenocarcinoma is protective for anastomotic dehiscence: a single-center observational retrospective cohort study

Authors: Damiano Caputo, Silvia Angeletti, Michele Fiore, Massimo Ciccozzi, Alessandro Coppola, Mariacristina Cartillone, Vincenzo La Vaccara, Giuseppe Spagnolo, Lucio Trodella, Roberto Coppola

Published in: Updates in Surgery | Issue 2/2020

Abstract

Ideal time interval between end of neoadjuvant radio-chemotherapy (NRCT) and surgery for rectal cancer is debated. Effect that different time intervals have on postoperative complications with particular regard to anastomotic dehiscence (AD) was evaluated on 167 patients who underwent surgery after long-course NRCT. Three different time intervals were considered: (0–42; 43–56; > 57 days). A time interval > 57 days was significantly protective for AD (p = 0.04, Odds ratio = 0.35; 95% CI 0.1254–0.9585) without influence on early oncological outcomes. Optimal time interval after end of NRCT and surgery may help achieving the best pathological response with lowest postoperative morbidity.

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Title: Delayed surgery after radio-chemotherapy for rectal adenocarcinoma is protective for anastomotic dehiscence: a single-center observational retrospective cohort study
Authors: Damiano Caputo
Silvia Angeletti
Michele Fiore
Massimo Ciccozzi
Alessandro Coppola
Mariacristina Cartillone
Vincenzo La Vaccara
Giuseppe Spagnolo
Lucio Trodella
Roberto Coppola
Publication date: 01-06-2020
Publisher: Springer International Publishing
Keywords: Rectal Cancer
Rectal Cancer
Cytostatic Therapy
Published in: Updates in Surgery / Issue 2/2020
Print ISSN: 2038-131X
Electronic ISSN: 2038-3312
DOI: https://doi.org/10.1007/s13304-020-00770-1

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Delayed surgery after radio-chemotherapy for rectal adenocarcinoma is protective for anastomotic dehiscence: a single-center observational retrospective cohort study

Abstract

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Abstract

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