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01-06-2020 | Rectal Cancer | Original Article

Clinical significance of an increased red blood cell distribution width in patients with rectal cancer undergoing chemoradiotherapy followed by surgery

Authors: Shozo Ide, Yuji Toiyama, Yoshinaga Okugawa, Yusuke Omura, Takahito Kitajima, Hiroyuki Fujikawa, Junichiro Hiro, Masaki Ohi, Masato Kusunoki

Published in: Surgery Today | Issue 6/2020

Abstract

Purpose

The clinical significance of the red blood cell distribution width (RDW) in patients with rectal cancer undergoing preoperative chemoradiotherapy (CRT) followed by surgery has not been fully evaluated.

Methods

In this retrospective study, we investigated the association between the RDW and the prognosis in 120 patients with locally advanced rectal cancer (LARC). We also performed a subgroup analysis limited to patients with pathological TNM stage I–II (ypN[−]) LARC.

Results

The RDW standard deviation was used to evaluate the RDW. We set 47.1% as the cut-off value of the RDW for the assessment of the prognosis. The RDW exhibited a significant negative relationship with the serum hemoglobin and albumin levels. An elevated RDW was an independent prognostic factor for the overall survival (OS) and disease-free survival (DFS) in patients with LARC. In addition, an elevated RDW predicted a poor OS and DFS in patients with pathological TNM stage I–II (ypN[−]) LARC.

Conclusions

The RDW is a promising predictor of a poor survival and recurrence in patients with LARC treated by CRT.

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Title: Clinical significance of an increased red blood cell distribution width in patients with rectal cancer undergoing chemoradiotherapy followed by surgery
Authors: Shozo Ide
Yuji Toiyama
Yoshinaga Okugawa
Yusuke Omura
Takahito Kitajima
Hiroyuki Fujikawa
Junichiro Hiro
Masaki Ohi
Masato Kusunoki
Publication date: 01-06-2020
Publisher: Springer Singapore
Keywords: Rectal Cancer
Rectal Cancer
Published in: Surgery Today / Issue 6/2020
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-019-01933-3

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Clinical significance of an increased red blood cell distribution width in patients with rectal cancer undergoing chemoradiotherapy followed by surgery

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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