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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 2/2020

01-02-2020 | Rectal Cancer | ASO Author Reflections

ASO Author Reflections: Tumor Location Affects Local Recurrence in Rectal Cancer

Authors: Clemens Franz, MD, Yakup Kulu, MD

Published in: Annals of Surgical Oncology | Issue 2/2020

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Excerpt

The circumferential resection margin (CRM) is one of the most important prognostic indicators in rectal cancer.1 Preoperative magnetic resonance imaging and evaluation of the CRM can identify those patients at high risk for local recurrence.2 Current guidelines recommend neoadjuvant treatment in all patients with American Joint Committee on Cancer (AJCC) stage II and III rectal cancer. However, local recurrence rates are similar with and without neoadjuvant treatment before surgery if only high-risk patients are selected for treatment.3,4 …
Literature
1.
Nagtegaal ID, Quirke P. What is the role for the circumferential margin in the modern treatment of rectal cancer? J Clin Oncol. 2008;26(2):303–312.CrossRef
2.
Taylor FG, Quirke P, Heald RJ, et al. Preoperative high-resolution magnetic resonance imaging can identify good prognosis stage I, II, and III rectal cancer best managed by surgery alone: a prospective, multicenter, European study. Ann Surg. 2011;253(4):711–719.CrossRef
3.
Ruppert R, Junginger T, Ptok H, et al. Oncological outcome after MRI-based selection for neoadjuvant chemoradiotherapy in the OCUM Rectal Cancer Trial. Br J Surg. 2018;105(11):1519–1529.CrossRef
4.
Kulu Y, Tarantino I, Billeter AT, et al. Comparative outcomes of neoadjuvant treatment prior to total mesorectal excision and total mesorectal excision alone in selected stage II/III low and mid rectal cancer. Ann Surg Oncol. 2016;23(1):106–113.CrossRef
5.
Metadata
Title
ASO Author Reflections: Tumor Location Affects Local Recurrence in Rectal Cancer
Authors
Clemens Franz, MD
Yakup Kulu, MD
Publication date
01-02-2020
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 2/2020
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-019-08032-0

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