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Open Access 01-12-2022 | Rectal Cancer | Commentary

A novel trial methodology to test interventions with very large effect sizes: the case of dostarlimab in mismatch repair-deficient, locally advanced rectal cancer

Authors: Kerrington Powell, Timothée Olivier, Vinay Prasad

Published in: Trials | Issue 1/2022

Abstract

Dostarlimab (Jemperli, GlaxoSmithKline) is an anti-programmed death receptor-1 monoclonal antibody (anti-PD-1) recently tested in a non-randomized, phase II trial (NCT04165772) which included patients with mismatch repair-deficient, locally advanced rectal cancer. Among the first 12 patients treated with dostarlimab, 100% achieved a clinical complete response with no patients experiencing progression or recurrence to date. Most impressive, none required chemotherapy, radiotherapy or surgery the prevailing standard of care. In this paper, we discuss the impressive results of this trial and how they relate to cancer policy, as well as propose a novel trial methodology to assess dostarlimab.

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Title: A novel trial methodology to test interventions with very large effect sizes: the case of dostarlimab in mismatch repair-deficient, locally advanced rectal cancer
Authors: Kerrington Powell
Timothée Olivier
Vinay Prasad
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Rectal Cancer
Rectal Cancer
Imatinib
Published in: Trials / Issue 1/2022
Electronic ISSN: 1745-6215
DOI: https://doi.org/10.1186/s13063-022-06988-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A novel trial methodology to test interventions with very large effect sizes: the case of dostarlimab in mismatch repair-deficient, locally advanced rectal cancer

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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