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International Journal of Colorectal Disease

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01-11-2021 | Rectal Cancer | Original Article

Disease recurrence after colorectal cancer surgery in the modern era: a population-based study

Authors: Seyed M. Qaderi, Boris Galjart, Cornelis Verhoef, Gerrit D. Slooter, Miriam Koopman, Robert H. A. Verhoeven, Johannes H. W. de Wilt, Felice N. van Erning

Published in: International Journal of Colorectal Disease | Issue 11/2021

Abstract

Purpose

This population-based study determined the cumulative incidence (CI) of local, regional, and distant recurrences, examined metastatic patterns, and identified risk factors for recurrence after curative treatment for CRC.

Methods

All patients undergoing resection for pathological stage I–III CRC between January 2015 and July 2015 and registered in the Netherlands Cancer Registry were selected (N = 5412). Additional patient record review and data collection on recurrences was conducted by trained administrators in 2019. Three-year CI of recurrence was calculated according to sublocation (right-sided: RCC, left-sided: LCC and rectal cancer: RC) and stage. Cox competing risk regression analyses were used to identify risk factors for recurrence.

Results

The 3-year CI of recurrence for stage I, II, and III RCC and LCC was 0.03 vs. 0.03, 0.12 vs. 0.16, and 0.31 vs. 0.24, respectively. The 3-year CI of recurrence for stage I, II, and III RC was 0.08, 0.24, and 0.38. Distant metastases were found in 14, 12, and 16% of patients with RCC, LCC, and RC. Multiple site metastases were found often in patients with RCC, LCC, and RC (42 vs. 32 vs. 28%). Risk factors for recurrence in stage I–II CRC were age 65–74 years, pT4 tumor size, and poor tumor differentiation whereas in stage III CRC, these were ASA III, pT4 tumor size, N2, and poor tumor differentiation.

Conclusions

Recurrence rates in recently treated patients with CRC were lower than reported in the literature and the metastatic pattern and recurrence risks varied between anatomical sublocations.

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Title: Disease recurrence after colorectal cancer surgery in the modern era: a population-based study
Authors: Seyed M. Qaderi
Boris Galjart
Cornelis Verhoef
Gerrit D. Slooter
Miriam Koopman
Robert H. A. Verhoeven
Johannes H. W. de Wilt
Felice N. van Erning
Publication date: 01-11-2021
Publisher: Springer Berlin Heidelberg
Keywords: Rectal Cancer
Metastasis
Rectal Cancer
Colorectal Cancer
Colorectal Cancer
Published in: International Journal of Colorectal Disease / Issue 11/2021
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-021-03914-w

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Springer Medicine

Disease recurrence after colorectal cancer surgery in the modern era: a population-based study

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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