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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-02-2018 | Inflammatory Disorders

Recovery of macular cone photoreceptors in Vogt-Koyanagi-Harada disease

Authors: Tomoko Nakamura, Atsushi Hayashi, Toshihiko Oiwake

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 2/2018

Abstract

Purpose

Our purpose was to study changes in macular cone photoreceptors in Vogt-Koyanagi-Harada (VKH) disease patients after high-dose corticosteroid treatment using an adaptive optics (AO) fundus camera.

Methods

We retrospectively analyzed 16 eyes of eight patients with new-onset acute VKH disease that were studied retrospectively. After serous retinal detachment (SRD) had resolved, AO images were obtained using the rtx1™ AO fundus camera over a 12-month course. Cone counting was performed in the nasal, temporal, superior and inferior areas of the macula 0.75 mm from the foveal center. A control group of 30 eyes of 30 healthy subjects was established for comparison.

Results

In the eyes with VKH disease, the mean cone densities 0.75 mm from the foveal center were 11,847 at baseline (resolution of SRD), and 15,218, 16,684 and 17,686 cones/mm², at 3, 6, and 12 months later, respectively. The mean cone densities at 3, 6, and 12 months were significantly increased compared to those of baseline (p = 0.007, p < 0.001, and p < 0.001, respectively); however, they were significantly lower than that of the healthy control eyes (p < 0.001). The mean cone densities at areas with a previous presence of cystoid spaces were significantly lower than those without cystoid spaces at the baseline, and at 3, 6, and 12 months (p < 0.001, p = 0.007, p < 0.001, and p = 0.008, respectively).

Conclusions

Cone densities were gradually increased after the resolution of SRD in the eyes of VKH disease patients. The presence of cystoid spaces might be a marker of severe damage to cone photoreceptors.

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Title: Recovery of macular cone photoreceptors in Vogt-Koyanagi-Harada disease
Authors: Tomoko Nakamura
Atsushi Hayashi
Toshihiko Oiwake
Publication date: 01-02-2018
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 2/2018
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-017-3869-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Recovery of macular cone photoreceptors in Vogt-Koyanagi-Harada disease

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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