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BMC Cancer
Published in: BMC Cancer 1/2018

Open Access 01-12-2018 | Research article

Reconsideration of the optimal minimum lymph node count for young colon cancer patients: a population-based study

Authors: Xu Guan, Yuliuming Wang, Hanqing Hu, Zhixun Zhao, Zheng Jiang, Zheng Liu, Yinggang Chen, Guiyu Wang, Xishan Wang

Published in: BMC Cancer | Issue 1/2018

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Abstract

Background

Currently, young colon cancer (CC) patients continue to increase and represent a heterogeneous patient group. The aim of this study was to explore the optimal minimum lymph node count after CC resection for young patients.

Methods

We performed a comprehensive search of the Surveillance, Epidemiology, and End Results (SEER) database, 2360 CC patients aged from 20 to 40 were analyzed. X-tile was used to determine the optimal cut-off point of lymph node based on survival outcomes of young patients. The cancer specific survival (CSS) was estimated with Kaplan-Meier method, the Cox proportional hazards regression model was used to analyse independent prognostic factors and exact 95% confidence intervals (CIs).

Results

Using X-tile analysis, 22-node measure was identified as the optimal choice for CC patients aged < 40. The 5-year CSS were 85.8% and 80.9% for patients examining ≥22 nodes and < 22 nodes. Furthermore, we identified that examining < 22 nodes was an independent adverse prognostic factor in patients aged < 40. In addition, the revised 22-node measure could examine more positive nodes than the standard 12-node measure in young patients.

Conclusions

For young colon cancer patients, the lymph node examination should be differently evaluated. We suggest that 22-node measure may be more suitable for CC patients aged < 40.

Trial registration

Retrospectively registered.
Appendix
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Metadata
Title
Reconsideration of the optimal minimum lymph node count for young colon cancer patients: a population-based study
Authors
Xu Guan
Yuliuming Wang
Hanqing Hu
Zhixun Zhao
Zheng Jiang
Zheng Liu
Yinggang Chen
Guiyu Wang
Xishan Wang
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-018-4428-0

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