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The Journal of Obstetrics and Gynecology of India

Published in:

01-12-2011 | Editorial

Recombinant or Urinary Human Chorionic Gonadotropin in Ovulation Induction?

Author: Gautam Allahbadia

Published in: The Journal of Obstetrics and Gynecology of India | Issue 6/2011

Excerpt

The onset of the spontaneous LH surge in women is relatively abrupt with concentrations doubling within 2 h to between 100 and 200 IU/l being sustained for 12–14 h over a mean duration of 50 h [1]. This mid-cycle surge, in addition to follicular rupture [2], promotes several peri-ovulatory events including disruption of the oocyte–cumulus oophorus cell contact and induction of the resumption of the oocyte’s meiotic maturation [3], cumulus oophorus mucification, luteinization of the follicular granulosa cells [4] and secretion of progesterone. …

Hoff JD, Quigley ME, Yen SSC. Hormonal dynamics at midcycle: a revelation. J Clin Endocrinol Metab. 1983;57:792–5.PubMedCrossRef

Espy LL. Ovarian proteolytic enzymes and ovulation. Biol Reprod. 1974;10:216–35.CrossRef

Laurence TS, Dekel N, Beers WH. Binding of human chorionic gonadotropin by rat cumuli oophori and granulosa cells: a comparative study. Endocrinology. 1980;106:1114–8.CrossRef

Brailly S, Gougeon A, Milgrom E. Androgens and progestins in the human ovarian follicle: differences in the evolution of preovulatory, healthy nonovulatory, and atretic follicles. J Clin Endocrinol Metab. 1981;53:128–34.PubMedCrossRef

Fischer RA, Nakajama ST, Gibson M, et al. Ovulation after intravenous and intramuscular human chorionic gonadotrophin. Fertil Steril. 1993;60:418–22.PubMed

Abdalla HI, Ah-Moye M, Brinsden P. The effect of the dose of human chorionic gonadotrophin stimulation on oocyte recovery rates in an in vitro fertilisation program. Fertil Steril. 1987;48:958–63.PubMed

Lunenfeld B, Insler V. From animal gonadotrophins to recombinant FSH. Perth: Ladybrook Publishing; 1999.

Ludwig M, Doody KJ, Doody KM. Use of recombinant human chorionic gonadotropin in ovulation induction. Fertil Steril. 2003;79(5):1051–9.PubMedCrossRef

Hincal F. An introduction to safety issues in biosimilars. Follow-on biopharmaceuticals. J Med CBR Def. 2009;7:1–17.

10.

Driscoll GL, Tyler JP, Hangan JT, et al. A prospective, randomized, controlled, double-blind, double-dummy comparison of recombinant and urinary HCG for inducing oocyte maturation and follicular luteinization in ovarian stimulation. Hum Reprod. 2000;15(6):1305–10.PubMedCrossRef

11.

International Recombinant Human Chorionic Gonadotropin Study Group. Induction of ovulation in World Health Organization group II anovulatory women undergoing follicular stimulation with recombinant human follicle-stimulating hormone: a comparison of recombinant human chorionic gonadotropin (rhCG) and urinary hCG. Fertil Steril. 2001;75(6):1111–8.CrossRef

12.

The European Recombinant Human Chorionic Gonadotrophin Study Group. Induction of final follicular maturation and early luteinization in women undergoing ovulation induction for assisted reproduction treatment-recombinant HCG versus urinary HCG. Hum Reprod. 2000;15(7):1446–51.CrossRef

13.

Farrag A, Costantini A, Manna C, et al. Recombinant HCG for triggering ovulation increases the rate of mature oocytes in women treated for ICSI. J Assist Reprod Genet. 2008;25(9–10):461–6.PubMedCrossRef

14.

Uhler ML, Beltsos AN, Grotjan HE, et al. Age-matched comparison of recombinant and urinary HCG for final follicular maturation. Reprod Biomed Online. 2006;13(3):315–20.PubMedCrossRef

15.

Abdelmassih V, Oliveira FG, Goncalves SP, et al. A prospective, randomized and blinded comparison between 10, 000 IU urinary and 250 μg recombinant human chorionic gonadotropin for oocyte maturation in in vitro fertilization cycles. J Assist Reprod Genet. 2005;22(4):149–53.PubMedCrossRef

16.

Kovacs P, Kovats T, Bernard A, et al. Comparison of serum and follicular fluid hormone levels with recombinant and urinary human chorionic gonadotropin during in vitro fertilization. Fertil Steril. 2008;90(6):2133–7. (Epub 2008 Jan 4).PubMedCrossRef

17.

Chan CC, Ng EH, Tang OS, et al. A prospective, randomized, double-blind study to compare two doses of recombinant human chorionic gonadotropin in inducing final oocyte maturity and the hormonal profile during the luteal phase. J Clin Endocrinol Metab. 2005;90(7):3933–8. (Epub 2005 May 3).PubMedCrossRef

18.

Littman ED, Milki AA. The combination of urinary and recombinant HCG improves outcome in patients with decreased oocyte/follicle ratio in previous cycles. Eur J Obstet Gynecol Reprod Biol. 2003;109(1):60–2.PubMedCrossRef

19.

Lorusso F, Palmisano M, Serratì G, et al. Intrauterine insemination with recombinant or urinary human chorionic gonadotropin: a prospective randomized trial. Gynecol Endocrinol. 2008;24(11):644–8.PubMedCrossRef

Title: Recombinant or Urinary Human Chorionic Gonadotropin in Ovulation Induction?
Author: Gautam Allahbadia
Publication date: 01-12-2011
Publisher: Springer-Verlag
Published in: The Journal of Obstetrics and Gynecology of India / Issue 6/2011
Print ISSN: 0971-9202
Electronic ISSN: 0975-6434
DOI: https://doi.org/10.1007/s13224-011-0114-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Recombinant or Urinary Human Chorionic Gonadotropin in Ovulation Induction?

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Keynote webinar | Spotlight on medication adherence

Springer Medicine

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