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Critical Care
Published in: Critical Care 1/2004

01-02-2004 | Poster presentation

Recombinant human activated protein C upregulates cyclooxygenase-2 and release of prostaglandins from cultured human endothelial cells via the endothelial protein C receptor

Authors: M Brueckmann, K Fukudome, S Horn, S Lang, V Liebe, U Hoffmann, M Borggrefe, K Haase, G Huhle

Published in: Critical Care | Special Issue 1/2004

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Excerpt

Cyclooxygenase-2 (COX-2) is the inducible COX isoform that catalyzes the formation of prostaglandins in response to proinflammatory cytokines. Prostacyclin, the major prostanoid generated by endothelial cells, is a potent inhibitor of platelet aggregation and a powerful vasodilator. Although the role of Drotrecogin alfa (activated) (recombinant human activated protein C [rhAPC]) in modulating microvascular coagulation through the inhibition of thrombin generation has been well studied in experimental and clinical settings of severe sepsis, little is known about its effects on prostanoid release from endothelial cells. …
Metadata
Title
Recombinant human activated protein C upregulates cyclooxygenase-2 and release of prostaglandins from cultured human endothelial cells via the endothelial protein C receptor
Authors
M Brueckmann
K Fukudome
S Horn
S Lang
V Liebe
U Hoffmann
M Borggrefe
K Haase
G Huhle
Publication date
01-02-2004
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 1/2004
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc2576

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