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BioDrugs
Published in: BioDrugs 5/2008

01-09-2008 | Drug Development

Recombinant Antibodies as Therapeutic Agents

Pathways for Modeling New Biodrugs

Authors: Frederico Aires da Silva, Sofia Corte-Real, Dr Joao Goncalves

Published in: BioDrugs | Issue 5/2008

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Abstract

Hybridoma fusion technology, proposed by Köhler and Milstein in 1975, started major developments in the field of monoclonal antibodies (mAbs). During the following 2 decades, their high potential as laboratory tools was rapidly exploited for biotechnology and biomedical applications. Today, mAbs represent over 30% of all biological proteins undergoing clinical trials and are the second largest class of biodrugs after vaccines. With the help of antibody engineering, mAbs have been reduced in size, rebuilt into multivalent molecules, and conjugated with drugs, toxins, or radioisotopes for the treatment of cancer, autoimmune disorders, graft rejection, and infectious diseases. Additionally, in the past few years, important advances have been made in the design, selection, and production of these new types of engineered antibodies. The present review focuses on the structural and functional characteristics of mAbs and their fragments, and also provides a walk through the most important methods used in antibody selection. In addition, the recent trends in antibody engineering for improving antibody clinical efficacy are also reviewed.
Footnotes
1
The use of trade names is for product identification purposes only and does not imply endorsement.
 
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Metadata
Title
Recombinant Antibodies as Therapeutic Agents
Pathways for Modeling New Biodrugs
Authors
Frederico Aires da Silva
Sofia Corte-Real
Dr Joao Goncalves
Publication date
01-09-2008
Publisher
Springer International Publishing
Published in
BioDrugs / Issue 5/2008
Print ISSN: 1173-8804
Electronic ISSN: 1179-190X
DOI
https://doi.org/10.2165/00063030-200822050-00003

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