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Published in: Immunologic Research 5/2021

01-10-2021 | Review

Recent advances in the role of Th17/Treg cells in tumor immunity and tumor therapy

Authors: Yin Qianmei, Su Zehong, Wang Guang, Li Hui, Gaojian Lian

Published in: Immunologic Research | Issue 5/2021

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Abstract

Th17 and Treg cells play an important role in regulating tissue inflammation and maintaining the stability of the immune system. They regulate inflammatory responses, participate in the occurrence and development of autoimmune diseases and tumors, and determine the disease progress. Malignant tumor is one of the diseases with the highest mortality rate in the world. However, the efficacy of traditional treatment is limited, so it is necessary to find safe and efficient treatment methods. Studies have shown that the balance of Th17/Treg cells plays a critical role in tumor progression. In this paper, we review the antitumor and tumor-suppressing effects of Th17/Treg cells, and new strategies for tumor therapy, combined with new research hotspots such as immune checkpoint therapy, miRNA-related gene therapy, and metabolic pathway regulation of Th17/Treg cell differentiation and tumor generation. The synergistic therapy is expected to be widely used in the future clinical practice, providing a new choice for the prevention and treatment of malignant tumors.
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Metadata
Title
Recent advances in the role of Th17/Treg cells in tumor immunity and tumor therapy
Authors
Yin Qianmei
Su Zehong
Wang Guang
Li Hui
Gaojian Lian
Publication date
01-10-2021
Publisher
Springer US
Published in
Immunologic Research / Issue 5/2021
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-021-09211-6

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