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Published in:

01-07-2009

Recent advances in the biology of WASP and WIP

Authors: Narayanaswamy Ramesh, Raif Geha

Published in: Immunologic Research | Issue 1-3/2009

Abstract

WASP, the product of the gene mutated in Wiskott–Aldrich syndrome, is expressed only in hematopoietic cells and is the archetype of a family of proteins that include N-WASP and Scar/WAVE. WASP plays a critical role in T cell activation and actin reorganization. WASP has multiple protein-interacting domains. Through its N-terminal EVH1 domain WASP binds to its partner WASP interacting protein (WIP) and through its C-terminal end it interacts with and activates the Arp2/3 complex. In lymphocytes, most of WASP is sequestered with WIP and binding to WIP is essential for the stability of WASP. The central proline-rich region of WASP serves as docking site to several adaptor proteins. Through these multiple interactions WASP integrates many cellular signals to actin cytoskeleton remodeling. In this review, we have summarized recent developments in the biology of WASP and the role of WIP in regulating WASP function. We also discuss WASP-independent functions of WIP.

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Title: Recent advances in the biology of WASP and WIP
Authors: Narayanaswamy Ramesh
Raif Geha
Publication date: 01-07-2009
Publisher: Humana Press Inc
Published in: Immunologic Research / Issue 1-3/2009
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-008-8086-1

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Recent advances in the biology of WASP and WIP

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