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01-12-2008 | Review

Recent advances in the aetiology of adolescent idiopathic scoliosis

Authors: Kenneth M. C. Cheung, T. Wang, G. X. Qiu, Keith D. K. Luk

Published in: International Orthopaedics | Issue 6/2008

Abstract

The aetiology of adolescent idiopathic scoliosis (AIS) is still unknown despite many years of research effort. Theories on AIS’s aetiology have included mechanical, hormonal, metabolic, neuromuscular, growth, and genetic abnormalities. Amongst these, some factors may be epiphenomena rather than the cause itself. Other factors may even contribute to curve progression, rather than curve initiation. Current views maintain that AIS is a multifactorial disease with genetic predisposing factors [Lowe et al. in J Bone Joint Surg [Am] 82:1157–1168, 2000]. With improvements in diagnostic methods, imaging and genomics, there has been considerable recent work on aetiology. This review aims to bring readers up-to-date with the latest developments in scoliosis research.

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Title: Recent advances in the aetiology of adolescent idiopathic scoliosis
Authors: Kenneth M. C. Cheung
T. Wang
G. X. Qiu
Keith D. K. Luk
Publication date: 01-12-2008
Publisher: Springer-Verlag
Published in: International Orthopaedics / Issue 6/2008
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-007-0393-y

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Recent advances in the aetiology of adolescent idiopathic scoliosis

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