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International Journal of Hematology
Published in: International Journal of Hematology 1/2011

01-07-2011 | Progress in Hematology

Reactive oxygen species and hematopoietic stem cell senescence

Authors: Lijian Shao, Hongliang Li, Senthil K. Pazhanisamy, Aimin Meng, Yong Wang, Daohong Zhou

Published in: International Journal of Hematology | Issue 1/2011

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Abstract

Hematopoietic stem cells (HSCs) are responsible for sustaining hematopoietic homeostasis and regeneration after injury for the entire lifespan of an organism through self-renewal, proliferation, differentiation, and mobilization. Their functions can be affected by reactive oxygen species (ROS) that are produced endogenously through cellular metabolism or after exposure to exogenous stress. At physiological levels, ROS function as signal molecules which can regulate a variety of cellular functions, including HSC proliferation, differentiation, and mobilization. However, an abnormal increase in ROS production occurs under various pathological conditions, which can inhibit HSC self-renewal and induce HSC senescence, resulting in premature exhaustion of HSCs and hematopoietic dysfunction. This review aims to provide a summary of a number of recent findings regarding the cellular sources of ROS in HSCs and the mechanisms of action whereby ROS induce HSC senescence. In particular, we highlight the roles of the p38 mitogen-activated protein kinase (p38)-p16Ink4a (p16) pathway in mediating ROS-induced HSC senescence.
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Metadata
Title
Reactive oxygen species and hematopoietic stem cell senescence
Authors
Lijian Shao
Hongliang Li
Senthil K. Pazhanisamy
Aimin Meng
Yong Wang
Daohong Zhou
Publication date
01-07-2011
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 1/2011
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-011-0872-1

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