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Breast Cancer Research
Published in: Breast Cancer Research 1/2008

01-02-2008 | Review

Re-evaluation of mammary stem cell biology based on in vivotransplantation

Authors: Gilbert H Smith, Daniel Medina

Published in: Breast Cancer Research | Issue 1/2008

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Abstract

Over nearly half a century, transplantation methods have been employed to regenerate the mammary gland in vivo. Recent highly cited reports claim to have demonstrated the regeneration of an entire functional mammary gland from a single mammary epithelial cell. Nevertheless, re-examination of the literature on the transplantation biology of mammary gland regeneration reveals that a complex, combinatorial interaction between variously differentiated mammary epithelial cells and the mammary fat pad stroma is indispensable to this process. In the present article, these issues are reviewed and discussed to provide a greater understanding of the complexity of these multiplex interactions.
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Metadata
Title
Re-evaluation of mammary stem cell biology based on in vivotransplantation
Authors
Gilbert H Smith
Daniel Medina
Publication date
01-02-2008
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 1/2008
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1856

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