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World Journal of Surgery

Published in:

01-11-2012

Randomized Controlled Trial of Tamsulosin for Prevention of Acute Voiding Difficulty After Rectal Cancer Surgery

Authors: Je-Ho Jang, Sung-Bum Kang, Sung-Min Lee, Jun-Seok Park, Duck-Woo Kim, Soyeon Ahn

Published in: World Journal of Surgery | Issue 11/2012

Abstract

Background

We conducted a randomized clinical trial to investigate the efficacy of the selective α_1A-adrenoceptor antagonist tamsulosin in preventing acute voiding difficulty after rectal cancer surgery.

Methods

A total of 94 rectal cancer patients with an International Prostate Symptom Score (IPSS) of ≤7 were randomly assigned (1:1) to the tamsulosin group (0.2 mg/day orally for 7 days) (n = 47) or the control group (n = 47). The primary endpoint was the reinsertion rate of the urinary catheter after its removal on postoperative day (POD) 3. The secondary endpoints included the maximum (Qmax) and average (Qavg) urinary flow rates on POD 3, and the voided volume (VV), residual urine volume (RU), and IPSS on POD 7. Analyses were based on an intention-to-treat population.

Results

The reinsertion rate of the urinary catheter in the tamsulosin group was similar to that in the control group (23.4 vs. 21.3 %, respectively; p = 0.804). The postoperative voiding parameters and IPSS were not better in the tamsulosin group than in the control group after adjustments were made for the baseline measurements with analysis of covariance (Qmax, p = 0.537; Qavg, p = 0.399; VV, p = 0.645; RU, p = 0.703; IPSS, p = 0.761). Multivariate analysis revealed that being male was the only independent risk factor for reinsertion of the urinary catheter (odds ratio 0.239; 95 % confidence interval 0.069–0.823; p = 0.023).

Conclusions

This controlled trial showed that tamsulosin at 0.2 mg/day does not prevent acute voiding difficulty after rectal cancer surgery.

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Title: Randomized Controlled Trial of Tamsulosin for Prevention of Acute Voiding Difficulty After Rectal Cancer Surgery
Authors: Je-Ho Jang
Sung-Bum Kang
Sung-Min Lee
Jun-Seok Park
Duck-Woo Kim
Soyeon Ahn
Publication date: 01-11-2012
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 11/2012
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-012-1712-z

At a glance: The STEP trials

Springer Medicine

Randomized Controlled Trial of Tamsulosin for Prevention of Acute Voiding Difficulty After Rectal Cancer Surgery

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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