Published in:
01-05-2010 | Poster presentation
Radiotherapy fraction size sensitivity is modulated by DNA repair systems
Authors:
N Somaiah, J Yarnold, F Daley, A Pearson, K Rothkamm, T Helleday
Published in:
Breast Cancer Research
|
Special Issue 1/2010
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Excerpt
There is level I evidence that breast cancers are significantly more sensitive to fraction size than previously thought, so that small fractions spare the cancer as much as the dose-limiting normal tissues. In skin, sensitivity to fraction size is associated with the proliferative status of cells in the basal epidermis, which are more sensitive to fraction size during the first 3 weeks of radiotherapy (RT) than during weeks 4 and 5. This study exploits RT-induced proliferation in human epidermis as a model of human cancer to investigate changes in DNA double-strand break (DSB) repair pathways postulated to determine RT fractionation sensitivity. …
