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Published in: Clinical Oral Investigations 7/2014

01-09-2014 | Original Article

Radiotherapy does not impair dentin adhesive properties in head and neck cancer patients

Authors: Roberta Galetti, Alan Roger Santos-Silva, Alberto Nogueira da Gama Antunes, Fabio de Abreu Alves, Marcio Ajudarte Lopes, Mario Fernando de Goes

Published in: Clinical Oral Investigations | Issue 7/2014

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Abstract

Objectives

This study evaluated the influence of radiotherapy on the dentin bond strength of teeth extracted from patients who had undergone head and neck radiotherapy.

Materials and methods

A total of 36 samples were divided into two experimental groups: group I (control group, n = 18) and group II (in vivo irradiated group, n = 18). Groups I and II were further separated into three subgroups (six specimens per subgroup), which were further assigned to the three adhesive system protocols employed: Single Bond 2 (SB) (3M ESPE), Easy Bond (EB) (3M ESPE) and Clearfil SE Bond (CSE) (Kuraray). The adhesive systems were applied to the prepared surface according to the manufacturers’ instructions and restored using composite resin (Filtek Supreme, 3M ESPE). After 24 h in deionised water (37oC), teeth were horizontally and vertically cut to obtain beam specimens with a cross-section area of 0.8 ± 1.0 mm2. Specimens were tested in tension using a universal testing machine at a cross-speed of 0.5 mm/min. Fracture patterns were observed under SEM. Data was analysed by two-way analysis of variance (p ≤ 0.05).

Results

No statistically significant difference was found between the irradiated (R/SB = 44.66 ± 10.12 MPa; R/EB = 41.48 ± 12.71 MPa; and R/CSE = 46.01 ± 6.98 MPa) and control group (C/SB = 39.12 ± 9.51 MPa; C/EB = 42.40 ± 6.66 MPa; and C/CSE = 36.58 ± 7.06 MPa) for any of the adhesive systems. All groups presented a predominance of mixed fracture modes.

Conclusion

Head and neck radiotherapy did not affect dentin bond strength for the adhesive materials tested in this study.
Literature
1.
go back to reference Kielbassa AM, Hinkelbein W, Hellwig E, Meyer-Lückel H (2006) Radiation-related damage to dentition. Lancet Oncol 7:326–335PubMedCrossRef Kielbassa AM, Hinkelbein W, Hellwig E, Meyer-Lückel H (2006) Radiation-related damage to dentition. Lancet Oncol 7:326–335PubMedCrossRef
2.
go back to reference Regezi JA, Courtney RM, Kerr DA (1976) Dental management of patients irradiated for oral cancer. Cancer 38:994–1000PubMedCrossRef Regezi JA, Courtney RM, Kerr DA (1976) Dental management of patients irradiated for oral cancer. Cancer 38:994–1000PubMedCrossRef
3.
go back to reference Sulaiman F, Huryn JM, Zlotolow IM (2003) Dental extractions in the irradiated head and neck patient: a retrospective analysis of memorial sloan-kettering cancer center protocols, criteria, and results. Br J Oral Maxillofac Surg 61:1123–1131CrossRef Sulaiman F, Huryn JM, Zlotolow IM (2003) Dental extractions in the irradiated head and neck patient: a retrospective analysis of memorial sloan-kettering cancer center protocols, criteria, and results. Br J Oral Maxillofac Surg 61:1123–1131CrossRef
4.
go back to reference Frank RM, Herdly J, Philippe E (1965) Acquired dental defects and salivary gland lesions after irradiation for carcinoma. J Am Dent Assoc 70:868–883PubMed Frank RM, Herdly J, Philippe E (1965) Acquired dental defects and salivary gland lesions after irradiation for carcinoma. J Am Dent Assoc 70:868–883PubMed
5.
go back to reference Silva ARS, Alves FA, Antunes A, De Goes MF, Lopes MA (2009) Patterns of demineralization and dentin reactions in radiation-related caries. Caries Res 43:43–49PubMedCrossRef Silva ARS, Alves FA, Antunes A, De Goes MF, Lopes MA (2009) Patterns of demineralization and dentin reactions in radiation-related caries. Caries Res 43:43–49PubMedCrossRef
6.
go back to reference Shaw MJ, Kumar NDK, Duggal M, Fiske J, Lewis DA, Kinsella T, Nisbet T (2000) Oral management of patients following oncology treatment: literature review. Br J Oral Maxillofac Surg 38:519–524PubMedCrossRef Shaw MJ, Kumar NDK, Duggal M, Fiske J, Lewis DA, Kinsella T, Nisbet T (2000) Oral management of patients following oncology treatment: literature review. Br J Oral Maxillofac Surg 38:519–524PubMedCrossRef
7.
go back to reference Andrews N, Griffiths C (2001) Dental complications of head and neck radiotherapy: Part 2. Aust Dent J 46:174–182PubMedCrossRef Andrews N, Griffiths C (2001) Dental complications of head and neck radiotherapy: Part 2. Aust Dent J 46:174–182PubMedCrossRef
8.
go back to reference Hancock PJ, Epstein JB, Sadler GR (2003) Oral and management related to radiation therapy for head and neck cancer. J Can Dent Assoc 69:585–590PubMed Hancock PJ, Epstein JB, Sadler GR (2003) Oral and management related to radiation therapy for head and neck cancer. J Can Dent Assoc 69:585–590PubMed
9.
go back to reference Silva ARS, Alves FA, Berger SB, Gianini M, De Goes MF, Lopes MA (2010) Radiation-related caries and early restoration failure in head and neck cancer patients. A polarized light microscopy and scanning electron microscopy study. Support Care Cancer 18:83–87PubMedCrossRef Silva ARS, Alves FA, Berger SB, Gianini M, De Goes MF, Lopes MA (2010) Radiation-related caries and early restoration failure in head and neck cancer patients. A polarized light microscopy and scanning electron microscopy study. Support Care Cancer 18:83–87PubMedCrossRef
10.
go back to reference Yadav S, Yadav H (2013) Ionizing irradiation affects the microtensile resin dentin bond strength under simulated clinical conditions. J Conserv Dent 16:148–151PubMedCentralPubMedCrossRef Yadav S, Yadav H (2013) Ionizing irradiation affects the microtensile resin dentin bond strength under simulated clinical conditions. J Conserv Dent 16:148–151PubMedCentralPubMedCrossRef
11.
go back to reference Kielbassa AM, Beetz I, Schendera A, Hellwig E (1997) Irradiation effects on microhardness of fluorated and non-fluorated bovine dentin. Eur J Oral Sci 105:444–447PubMedCrossRef Kielbassa AM, Beetz I, Schendera A, Hellwig E (1997) Irradiation effects on microhardness of fluorated and non-fluorated bovine dentin. Eur J Oral Sci 105:444–447PubMedCrossRef
12.
go back to reference Naves LZ, Novais VR, Armstrong SR, Correr-Sobrinho L, Soares CJ (2012) Effect of gamma radiation on bonding to human enamel and dentin. Support Care Cancer 20:2873–2878PubMedCrossRef Naves LZ, Novais VR, Armstrong SR, Correr-Sobrinho L, Soares CJ (2012) Effect of gamma radiation on bonding to human enamel and dentin. Support Care Cancer 20:2873–2878PubMedCrossRef
13.
go back to reference Kielbassa AM (2000) In situ induced demineralization in irradiated and non-irradiated human dentin. Eur J Oral Sci 108:214–221PubMedCrossRef Kielbassa AM (2000) In situ induced demineralization in irradiated and non-irradiated human dentin. Eur J Oral Sci 108:214–221PubMedCrossRef
14.
go back to reference Kielbassa AM, Schendera A, Schulte-Mönting J (2000) Microradiographic and microscopic studies on in situ induced initial caries in irradiated and nonirradiated dental enamel. Caries Res 34:41–47PubMedCrossRef Kielbassa AM, Schendera A, Schulte-Mönting J (2000) Microradiographic and microscopic studies on in situ induced initial caries in irradiated and nonirradiated dental enamel. Caries Res 34:41–47PubMedCrossRef
15.
go back to reference Jansma J, Vissink A, Spijkervet FKL, Roodenburg JLN, Panders AK, Vermey A, Szabó BG, Gravenmade EJ (1992) Protocol for the prevention and treatment of oral sequelae resulting from head and neck radiation therapy. Cancer 70:2171–2180PubMedCrossRef Jansma J, Vissink A, Spijkervet FKL, Roodenburg JLN, Panders AK, Vermey A, Szabó BG, Gravenmade EJ (1992) Protocol for the prevention and treatment of oral sequelae resulting from head and neck radiation therapy. Cancer 70:2171–2180PubMedCrossRef
16.
go back to reference Hong CHL, Napeñas JJ, Hodgson BD, Stokman MA, Mathers-Stauffer V, Elting LS, Spijkervet FK, Brennan MT (2010) A systematic review of dental disease in patients undergoing cancer therapy. Support Care Cancer 18:1007–1021PubMedCentralPubMedCrossRef Hong CHL, Napeñas JJ, Hodgson BD, Stokman MA, Mathers-Stauffer V, Elting LS, Spijkervet FK, Brennan MT (2010) A systematic review of dental disease in patients undergoing cancer therapy. Support Care Cancer 18:1007–1021PubMedCentralPubMedCrossRef
17.
go back to reference Hu JY, Smales RJ, Li YQ, Yip KH (2002) Restoration of teeth with more-viscous glass ionomer cements following radiation-induced caries. Int Dent J 52:445–448PubMedCrossRef Hu JY, Smales RJ, Li YQ, Yip KH (2002) Restoration of teeth with more-viscous glass ionomer cements following radiation-induced caries. Int Dent J 52:445–448PubMedCrossRef
18.
go back to reference Schratter-Sehn AU, Schmidt WF, Kielhauser R, Langer H, Kärcher KH (1992) The prevention of mucosal lesions during oropharyngeal irradiation with a dental-filling shield. Strahlenther Onkol 168:35–38PubMed Schratter-Sehn AU, Schmidt WF, Kielhauser R, Langer H, Kärcher KH (1992) The prevention of mucosal lesions during oropharyngeal irradiation with a dental-filling shield. Strahlenther Onkol 168:35–38PubMed
19.
go back to reference Mcomb D, Erickson RL, Maxymiw WG, Wood RE (2002) A clinical comparison of glass ionomer, resin modified glass ionomer and resin composites restorations in the treatment of cervical caries in xerostomic head and neck radiation patients. Oper Dent 27:430–437 Mcomb D, Erickson RL, Maxymiw WG, Wood RE (2002) A clinical comparison of glass ionomer, resin modified glass ionomer and resin composites restorations in the treatment of cervical caries in xerostomic head and neck radiation patients. Oper Dent 27:430–437
20.
go back to reference Odlum O (1991) Preventive resins in the management of radiation-induced xerostomia complications. J Esthet Dent 3:227–229PubMedCrossRef Odlum O (1991) Preventive resins in the management of radiation-induced xerostomia complications. J Esthet Dent 3:227–229PubMedCrossRef
21.
go back to reference Gernhardt CR, Kielbassa AM, Hahn P, Schaller HG (2001) Tensile bond strengths of four different dentin adhesives on irradiated and non-irradiated human dentin in vitro. J Oral Rehabil 28:814–820PubMedCrossRef Gernhardt CR, Kielbassa AM, Hahn P, Schaller HG (2001) Tensile bond strengths of four different dentin adhesives on irradiated and non-irradiated human dentin in vitro. J Oral Rehabil 28:814–820PubMedCrossRef
22.
go back to reference Inoue S, Vargas MA, Abe Y, Yoshida Y, Lambrechts P, Vanherle G, Sano H, Van Meerbeek B (2003) Microtensile bond strength of eleven contemporary adhesives to enamel. Am J Dent 16:329–334PubMed Inoue S, Vargas MA, Abe Y, Yoshida Y, Lambrechts P, Vanherle G, Sano H, Van Meerbeek B (2003) Microtensile bond strength of eleven contemporary adhesives to enamel. Am J Dent 16:329–334PubMed
23.
go back to reference Perdigão J, Geraldeli S, Carmo AR, Dutra HR (2002) In vivo influence of residual moisture on microtensile bond strengths of one-bottle adhesives. J Esthet Restor Dent 14:31–38PubMedCrossRef Perdigão J, Geraldeli S, Carmo AR, Dutra HR (2002) In vivo influence of residual moisture on microtensile bond strengths of one-bottle adhesives. J Esthet Restor Dent 14:31–38PubMedCrossRef
24.
go back to reference Bodrumlu E, Avsar A, Meydan AD, Tuloglu N (2009) Can radiotherapy affect the apical sealing ability of resin-based root canal sealers. J Am Dent Assoc 140:326–330PubMedCrossRef Bodrumlu E, Avsar A, Meydan AD, Tuloglu N (2009) Can radiotherapy affect the apical sealing ability of resin-based root canal sealers. J Am Dent Assoc 140:326–330PubMedCrossRef
25.
go back to reference Gernhardt CR, Koravu T, Gerlach R, Schaller HG (2004) The influence of dentin adhesives on the demineralization of irradiated and non-irradiated human root dentin. Oper Dent 29:454–461PubMed Gernhardt CR, Koravu T, Gerlach R, Schaller HG (2004) The influence of dentin adhesives on the demineralization of irradiated and non-irradiated human root dentin. Oper Dent 29:454–461PubMed
26.
go back to reference Kielbassa AM, Wrbas KT, Schulte-Mönting J, Hellwig E (1999) Correlation of transversal microradiography and microhardness on in situ-induced demineralization in irradiated and nonirradiated human dental enamel. Arch Oral Biol 44:243–251PubMedCrossRef Kielbassa AM, Wrbas KT, Schulte-Mönting J, Hellwig E (1999) Correlation of transversal microradiography and microhardness on in situ-induced demineralization in irradiated and nonirradiated human dental enamel. Arch Oral Biol 44:243–251PubMedCrossRef
27.
go back to reference Pioch T, Staehle HJ (1996) Experimental investigation of the shear strengths of teeth in the region of the dentinoenamel junction. Quintessence Int 7:711–714 Pioch T, Staehle HJ (1996) Experimental investigation of the shear strengths of teeth in the region of the dentinoenamel junction. Quintessence Int 7:711–714
28.
go back to reference Bulucu B, Avsar A, Demiryürek EO, Yesilyurt C (2009) Effect of radiotherapy on the microleakage of adhesive systems. J Adhes Dent 11:305–309PubMed Bulucu B, Avsar A, Demiryürek EO, Yesilyurt C (2009) Effect of radiotherapy on the microleakage of adhesive systems. J Adhes Dent 11:305–309PubMed
29.
go back to reference Hey J, Seidel J, Schweyen R, Paelecke Habermann Y, Vordemark D, Gernhardt C, Kuhnt T (2013) The influence of parotid gland sparing on radiation damages of dental hard tissue. Clin Oral Investig 17:1619–1625PubMedCrossRef Hey J, Seidel J, Schweyen R, Paelecke Habermann Y, Vordemark D, Gernhardt C, Kuhnt T (2013) The influence of parotid gland sparing on radiation damages of dental hard tissue. Clin Oral Investig 17:1619–1625PubMedCrossRef
30.
go back to reference Gomez DR, Estilo CL, Wolden SL, Zelefsky MJ, Kraus DH, Wong RJ, Shaha AR, Shah JP, Mechalakos JG, Lee NY (2011) Correlation of osteoradionecrosis and dental events with dosimetric parameters in intensity-modulation radiation therapy for head and neck cancer. Int J Radiat Oncol Biol Phys 81:207–213CrossRef Gomez DR, Estilo CL, Wolden SL, Zelefsky MJ, Kraus DH, Wong RJ, Shaha AR, Shah JP, Mechalakos JG, Lee NY (2011) Correlation of osteoradionecrosis and dental events with dosimetric parameters in intensity-modulation radiation therapy for head and neck cancer. Int J Radiat Oncol Biol Phys 81:207–213CrossRef
31.
go back to reference Van Meerbeek B, De Munk J, Yoshida Y, Inoue S, Vargas M, Vijay P, Van Landuyt K, Lambrechts P, Vanherle G (2003) Buonocore memorial lecture—adhesion to enamel and dentin: current status and future challenges. Oper Dent 28:215–235PubMed Van Meerbeek B, De Munk J, Yoshida Y, Inoue S, Vargas M, Vijay P, Van Landuyt K, Lambrechts P, Vanherle G (2003) Buonocore memorial lecture—adhesion to enamel and dentin: current status and future challenges. Oper Dent 28:215–235PubMed
32.
go back to reference Tay FR, King NM, Chan KM, Pashley DH (2002) How can nanoleakage occur in self-etching adhesive systems that demineralize and infiltrate simultaneously? J Adhes Dent 4:255–269PubMed Tay FR, King NM, Chan KM, Pashley DH (2002) How can nanoleakage occur in self-etching adhesive systems that demineralize and infiltrate simultaneously? J Adhes Dent 4:255–269PubMed
33.
go back to reference Springer IN, Niehoff P, Warnke PH, Böcek G, Kovács G, Suhr M, Wiltfang J, Açil Y (2005) Radiation caries-radiogenic destruction of dental collagen. Oral Oncol 41:723–728PubMedCrossRef Springer IN, Niehoff P, Warnke PH, Böcek G, Kovács G, Suhr M, Wiltfang J, Açil Y (2005) Radiation caries-radiogenic destruction of dental collagen. Oral Oncol 41:723–728PubMedCrossRef
Metadata
Title
Radiotherapy does not impair dentin adhesive properties in head and neck cancer patients
Authors
Roberta Galetti
Alan Roger Santos-Silva
Alberto Nogueira da Gama Antunes
Fabio de Abreu Alves
Marcio Ajudarte Lopes
Mario Fernando de Goes
Publication date
01-09-2014
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 7/2014
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-013-1155-4

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