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Published in: European Journal of Nuclear Medicine and Molecular Imaging 12/2022

10-08-2022 | Radioiodine Therapy | Editorial

SNMMI/EANM practice guideline vs. ETA Consensus Statement: differences and similarities in approaching differentiated thyroid cancer management—the EANM perspective

Authors: Petra Petranović Ovčariček, Michael C. Kreissl, Alfredo Campenni, Bart de Keizer, Murat Tuncel, Alexis Vrachimis, Desiree Deandreis, Luca Giovanella

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 12/2022

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Excerpt

During the last few years, especially since the American Thyroid Association guidelines was released in 2015, there has been an intense debate on the management of thyroid cancer with particular emphasis on the use of radioactive iodine for diagnostic and therapeutic purposes. The Society of Nuclear Medicine and Molecular Imaging (SNMMI) and The European Association of Nuclear Medicine (EANM) have just published joint practice guidelines on the nuclear medicine evaluation and therapy of differentiated thyroid cancer (DTC) [1]. Recently, the European Thyroid Association (ETA) also released the 2022 ETA Consensus Statement: “What are the indications for post-surgical radioiodine therapy in differentiated thyroid cancer?” [2]. In addition, not long ago, a German position paper from surgery and nuclear medicine was published in reaction to the ETA Consensus Statement with a very different perspective, similar to the newly published SNMMI/EANM guideline [3]. Overall, despite the use of the widely accepted risk-adapted therapy, its interpretation and relative approaches to DTC management, and in particular to the clinical use of radioactive iodine, still differ significantly in European countries [4]. …
Literature
1.
go back to reference Avram AM, Giovanella L, Greenspan B, Lawson SA, Luster M, Van Nostrand D, et al. SNMMI procedure standard/EANM practice guideline for nuclear medicine evaluation and therapy of differentiated thyroid cancer: abbreviated version. J Nucl Med. 2022;63(6):15N-35N.PubMed Avram AM, Giovanella L, Greenspan B, Lawson SA, Luster M, Van Nostrand D, et al. SNMMI procedure standard/EANM practice guideline for nuclear medicine evaluation and therapy of differentiated thyroid cancer: abbreviated version. J Nucl Med. 2022;63(6):15N-35N.PubMed
2.
go back to reference Pacini F, Fuhrer D, Elisei R, Handkiewicz-Junak D, Leboulleux S, Luster M, et al. 2022 ETA Consensus Statement: what are the indications for post-surgical radioiodine therapy in differentiated thyroid cancer? Eur Thyroid J. 2022;11(1):e210046. CrossRef Pacini F, Fuhrer D, Elisei R, Handkiewicz-Junak D, Leboulleux S, Luster M, et al. 2022 ETA Consensus Statement: what are the indications for post-surgical radioiodine therapy in differentiated thyroid cancer? Eur Thyroid J. 2022;11(1):e210046. CrossRef
3.
go back to reference Schmidt M, Bartenstein P, Bucerius J, Dietlein M, Drzezga A, Herrmann K, Lapa C, Lorenz K, Musholt TJ, Nagarajah J, Reiners C, Sahlmann CO, Kreissl MC. Individualized treatment of differentiated thyroid cancer: The value of surgery in combination with radioiodine imaging and therapy - A German position paper from surgery and nuclear medicine. Nuklearmedizin. 2022;61(2):87–96. English, German. Erratum in: Nuklearmedizin. Schmidt M, Bartenstein P, Bucerius J, Dietlein M, Drzezga A, Herrmann K, Lapa C, Lorenz K, Musholt TJ, Nagarajah J, Reiners C, Sahlmann CO, Kreissl MC. Individualized treatment of differentiated thyroid cancer: The value of surgery in combination with radioiodine imaging and therapy - A German position paper from surgery and nuclear medicine. Nuklearmedizin. 2022;61(2):87–96. English, German. Erratum in: Nuklearmedizin.
4.
go back to reference Forrer F, Fischer GF, Maas O, Giovanella L, Hoffmann M, Iakovou I, et al. Variations in radioiodine therapy in Europe: decision-making after total thyroidectomy. Oncology. 2022;100(2):74–81.CrossRef Forrer F, Fischer GF, Maas O, Giovanella L, Hoffmann M, Iakovou I, et al. Variations in radioiodine therapy in Europe: decision-making after total thyroidectomy. Oncology. 2022;100(2):74–81.CrossRef
5.
go back to reference Ruel E, Thomas S, Dinan M, Perkins JM, Roman SA, Sosa JA. Adjuvant radioactive iodine therapy is associated with improved survival for patients with intermediate-risk papillary thyroid cancer. J Clin Endocrinol Metab. 2015;100(4):1529–36.CrossRef Ruel E, Thomas S, Dinan M, Perkins JM, Roman SA, Sosa JA. Adjuvant radioactive iodine therapy is associated with improved survival for patients with intermediate-risk papillary thyroid cancer. J Clin Endocrinol Metab. 2015;100(4):1529–36.CrossRef
6.
go back to reference Sawka AM, Thephamongkhol K, Brouwers M, Thabane L, Browman G, Gerstein HC. Clinical review 170: a systematic review and metaanalysis of the effectiveness of radioactive iodine remnant ablation for well-differentiated thyroid cancer. J Clin Endocrinol Metab. 2004;89(8):3668–76.CrossRef Sawka AM, Thephamongkhol K, Brouwers M, Thabane L, Browman G, Gerstein HC. Clinical review 170: a systematic review and metaanalysis of the effectiveness of radioactive iodine remnant ablation for well-differentiated thyroid cancer. J Clin Endocrinol Metab. 2004;89(8):3668–76.CrossRef
7.
go back to reference Albano D, Bertagna F, Bonacina M, Durmo R, Cerudelli E, Gazzilli M, et al. Possible delayed diagnosis and treatment of metastatic differentiated thyroid cancer by adopting the 2015 ATA guidelines. Eur J Endocrinol. 2018;179(3):143–51.CrossRef Albano D, Bertagna F, Bonacina M, Durmo R, Cerudelli E, Gazzilli M, et al. Possible delayed diagnosis and treatment of metastatic differentiated thyroid cancer by adopting the 2015 ATA guidelines. Eur J Endocrinol. 2018;179(3):143–51.CrossRef
8.
go back to reference Spanu A, Nuvoli S, Marongiu A, Gelo I, Mele L, Piras B, et al. Neck lymph node metastasis detection in patients with differentiated thyroid carcinoma (DTC) in long-term follow-up: a 131 I-SPECT/CT study. BMC Cancer. 2020;20(1):239.CrossRef Spanu A, Nuvoli S, Marongiu A, Gelo I, Mele L, Piras B, et al. Neck lymph node metastasis detection in patients with differentiated thyroid carcinoma (DTC) in long-term follow-up: a 131 I-SPECT/CT study. BMC Cancer. 2020;20(1):239.CrossRef
9.
go back to reference Campennì A, Giovanella L, Pignata SA, Vento A, Alibrandi A, Sturiale L, et al. Undetectable or low (<1 ng/ml) postsurgical thyroglobulin values do not rule out metastases in early stage differentiated thyroid cancer patients. Oncotarget. 2018;9(25):17491–500.CrossRef Campennì A, Giovanella L, Pignata SA, Vento A, Alibrandi A, Sturiale L, et al. Undetectable or low (<1 ng/ml) postsurgical thyroglobulin values do not rule out metastases in early stage differentiated thyroid cancer patients. Oncotarget. 2018;9(25):17491–500.CrossRef
10.
go back to reference Perros P, Boelaert K, Colley S, Evans C, Evans RM, Gerrard Ba G, et al. Guidelines for the management of thyroid cancer. Clin Endocrinol (Oxf). 2014;81(Suppl 1(SUPPL. 1)):1–122.CrossRef Perros P, Boelaert K, Colley S, Evans C, Evans RM, Gerrard Ba G, et al. Guidelines for the management of thyroid cancer. Clin Endocrinol (Oxf). 2014;81(Suppl 1(SUPPL. 1)):1–122.CrossRef
11.
go back to reference Leenhardt L, Leboulleux S, Bournaud C, Zerdoud S, Schvartz C, Ciappuccini R, et al. Recombinant thyrotropin vs levothyroxine withdrawal in 131I therapy of N1 thyroid cancer: a large matched cohort study (ThyrNod). J Clin Endocrinol Metab. 2019;104(4):1020–8.CrossRef Leenhardt L, Leboulleux S, Bournaud C, Zerdoud S, Schvartz C, Ciappuccini R, et al. Recombinant thyrotropin vs levothyroxine withdrawal in 131I therapy of N1 thyroid cancer: a large matched cohort study (ThyrNod). J Clin Endocrinol Metab. 2019;104(4):1020–8.CrossRef
12.
go back to reference Pacini F, Ladenson PW, Schlumberger M, Driedger A, Luster M, Kloos RT, et al. Radioiodine ablation of thyroid remnants after preparation with recombinant human thyrotropin in differentiated thyroid carcinoma: results of an international, randomized, controlled study. J Clin Endocrinol Metab. 2006;91(3):926–32.CrossRef Pacini F, Ladenson PW, Schlumberger M, Driedger A, Luster M, Kloos RT, et al. Radioiodine ablation of thyroid remnants after preparation with recombinant human thyrotropin in differentiated thyroid carcinoma: results of an international, randomized, controlled study. J Clin Endocrinol Metab. 2006;91(3):926–32.CrossRef
13.
go back to reference Michael Tuttle R, Ahuja S, Avram AM, Bernet VJ, Bourguet P, Daniels GH, et al. Controversies, consensus, and collaboration in the use of 131 i therapy in differentiated thyroid cancer: a joint statement from the American Thyroid Association, the European Association of Nuclear Medicine, the Society of Nuclear Medicine and Molecular Imaging, and the European Thyroid Association. Thyroid. 2019;29(4):461–70.CrossRef Michael Tuttle R, Ahuja S, Avram AM, Bernet VJ, Bourguet P, Daniels GH, et al. Controversies, consensus, and collaboration in the use of 131 i therapy in differentiated thyroid cancer: a joint statement from the American Thyroid Association, the European Association of Nuclear Medicine, the Society of Nuclear Medicine and Molecular Imaging, and the European Thyroid Association. Thyroid. 2019;29(4):461–70.CrossRef
14.
go back to reference Zanotti-Fregonara P, Hindié E. On the effectiveness of recombinant human TSH as a stimulating agent for 131I treatment of metastatic differentiated thyroid cancer. Eur J Nucl Med Mol Imaging. 2010;37(12):2264–6.CrossRef Zanotti-Fregonara P, Hindié E. On the effectiveness of recombinant human TSH as a stimulating agent for 131I treatment of metastatic differentiated thyroid cancer. Eur J Nucl Med Mol Imaging. 2010;37(12):2264–6.CrossRef
15.
go back to reference Plyku D, Hobbs RF, Huang K, Atkins F, Garcia C, Sgouros G, et al. Recombinant human thyroid-stimulating hormone versus thyroid hormone withdrawal in 124 I PET/CT-based dosimetry for 131 I therapy of metastatic differentiated thyroid cancer. J Nucl Med. 2017;58(7):1146–54.CrossRef Plyku D, Hobbs RF, Huang K, Atkins F, Garcia C, Sgouros G, et al. Recombinant human thyroid-stimulating hormone versus thyroid hormone withdrawal in 124 I PET/CT-based dosimetry for 131 I therapy of metastatic differentiated thyroid cancer. J Nucl Med. 2017;58(7):1146–54.CrossRef
16.
go back to reference Gulec SA, Ahuja S, Avram AM, Bernet VJ, Bourguet P, Draganescu C, et al. A joint statement from the American Thyroid Association, the European Association of Nuclear Medicine, the European Thyroid Association, the Society of Nuclear Medicine and Molecular Imaging on Current Diagnostic and Theranostic Approaches in the Management of Thyroid Cancer. Thyroid. 2021;31(7):1009–19.CrossRef Gulec SA, Ahuja S, Avram AM, Bernet VJ, Bourguet P, Draganescu C, et al. A joint statement from the American Thyroid Association, the European Association of Nuclear Medicine, the European Thyroid Association, the Society of Nuclear Medicine and Molecular Imaging on Current Diagnostic and Theranostic Approaches in the Management of Thyroid Cancer. Thyroid. 2021;31(7):1009–19.CrossRef
17.
go back to reference Van Nostrand D, Aiken M, Atkins F, Moreau S, Garcia C, Acio E, et al. The utility of radioiodine scans prior to iodine 131 ablation in patients with well-differentiated thyroid cancer. Thyroid. 2009;19(8):849–55.CrossRef Van Nostrand D, Aiken M, Atkins F, Moreau S, Garcia C, Acio E, et al. The utility of radioiodine scans prior to iodine 131 ablation in patients with well-differentiated thyroid cancer. Thyroid. 2009;19(8):849–55.CrossRef
18.
go back to reference Wong KK, Sisson JC, Koral KF, Frey KA, Avram AM. Staging of differentiated thyroid carcinoma using diagnostic 131I SPECT/CT. AJR Am J Roentgenol. 2010;195(3):730–6.CrossRef Wong KK, Sisson JC, Koral KF, Frey KA, Avram AM. Staging of differentiated thyroid carcinoma using diagnostic 131I SPECT/CT. AJR Am J Roentgenol. 2010;195(3):730–6.CrossRef
19.
go back to reference Konijnenberg M, Herrmann K, Kobe C, Verburg F, Hindorf C, Hustinx R, et al. EANM position paper on article 56 of the Council Directive 2013/59/Euratom (basic safety standards) for nuclear medicine therapy. Eur J Nucl Med Mol Imaging. 2021;48(1):67–72.CrossRef Konijnenberg M, Herrmann K, Kobe C, Verburg F, Hindorf C, Hustinx R, et al. EANM position paper on article 56 of the Council Directive 2013/59/Euratom (basic safety standards) for nuclear medicine therapy. Eur J Nucl Med Mol Imaging. 2021;48(1):67–72.CrossRef
20.
go back to reference Avram AM, Rosculet N, Esfandiari NH, Gauger PG, Miller BS, Cohen M, et al. Differentiated thyroid cancer outcomes after surgery and activity-adjusted 131I theragnostics. Clin Nucl Med. 2019;44(1):11–20.CrossRef Avram AM, Rosculet N, Esfandiari NH, Gauger PG, Miller BS, Cohen M, et al. Differentiated thyroid cancer outcomes after surgery and activity-adjusted 131I theragnostics. Clin Nucl Med. 2019;44(1):11–20.CrossRef
Metadata
Title
SNMMI/EANM practice guideline vs. ETA Consensus Statement: differences and similarities in approaching differentiated thyroid cancer management—the EANM perspective
Authors
Petra Petranović Ovčariček
Michael C. Kreissl
Alfredo Campenni
Bart de Keizer
Murat Tuncel
Alexis Vrachimis
Desiree Deandreis
Luca Giovanella
Publication date
10-08-2022
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 12/2022
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-022-05935-1

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