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01-11-2008 | Breast Oncology

Radiofrequency Thermal Ablation of Breast Cancer Local Recurrence: A Phase II Clinical Trial

Authors: Jean-Rémi Garbay, MD, Marie-Christine Mathieu, MD, Michele Lamuraglia, MD, Nathalie Lassau, MD, PhD, Corrine Balleyguier, MD, Roman Rouzier, MD, PhD

Published in: Annals of Surgical Oncology | Issue 11/2008

Abstract

Background

The role of radiofrequency (RF) ablation to treat local recurrence of breast cancer is unknown.

Methods

We conducted a two-stage phase II clinical trial. Eligible patients had a histologically confirmed noninflammatory and ≤3 cm ipsilateral breast tumor recurrence. The tumor site was identified by intraoperative sonography. A LeVeen needle electrode (RadioTherapeutics Corp, Mountain View, Calif) was inserted into a single site within the tumor and radiofrequency ablation was performed using a RF-2000 generator (RadioTherapeutics Corp). After completion of radiofrequency, a mastectomy was performed. Conventional staining and nicotinamide adenine dinucleotide-diaphorase (NADH-diaphorase) cell viability staining were performed.

Results

During the first stage, procedures were uneventful. Conventional, cytokeratin, and NADH-diaphorase staining identified persistent viable tumor cells in the RF-ablated region in three patients. This phase II trial was stopped after completion of the first stage because of insufficient efficacy.

Conclusion

We demonstrate in this study that RF ablation is a potential technique to destroy local recurrence of breast tumors but the technique we tested in this phase II clinical trial had insufficient efficacy to recommend its use in routine.

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Title: Radiofrequency Thermal Ablation of Breast Cancer Local Recurrence: A Phase II Clinical Trial
Authors: Jean-Rémi Garbay, MD
Marie-Christine Mathieu, MD
Michele Lamuraglia, MD
Nathalie Lassau, MD, PhD
Corrine Balleyguier, MD
Roman Rouzier, MD, PhD
Publication date: 01-11-2008
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 11/2008
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-008-0026-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Radiofrequency Thermal Ablation of Breast Cancer Local Recurrence: A Phase II Clinical Trial

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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