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Journal of Medical Case Reports

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Open Access 01-12-2008 | Case report

Radiofrequency-induced thermotherapy of nasopharyngeal angiofibroma and immunohistochemical analysis of vessel proliferation: a case report

Authors: Mira Krstulja, Milodar Kujundžić, Adelaida Halaj, Tamara Braut, Niko Cvjetković

Published in: Journal of Medical Case Reports | Issue 1/2008

Abstract

Introduction

Nasopharyngeal angiofibroma presents with symptoms of nasal obstruction and epistaxis. The treatment of choice is embolization followed by surgery.

Case presentation

A 52-year-old man underwent surgery for nasopharyngeal angiofibroma after adjuvant radiofrequency-induced thermotherapy. To the best of the authors' knowledge, this is the first case of angiofibroma with clinical follow-up after thermocoagulation therapy supported by quantitative, double immunohistochemistry. We found this case of angiofibroma to be of interest owing to the presentation of symptoms leading to biopsy, the pathohistological observations obtained with synchronous Ki67/cluster of differentiation 34 and Ki67/smooth muscle actin immunohistochemistry and high pericyte proliferation.

Conclusion

Coagulation of angiofibroma vessels followed by acquisition of a thick mantle of pericytes in a patient with a nasopharyngeal growth suggests that radiofrequency-induced thermotherapy could be a useful, palliative therapy for bleeding nasopharyngeal angiofibroma, supporting vessel maturation prior to surgical tumor removal.

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Title: Radiofrequency-induced thermotherapy of nasopharyngeal angiofibroma and immunohistochemical analysis of vessel proliferation: a case report
Authors: Mira Krstulja
Milodar Kujundžić
Adelaida Halaj
Tamara Braut
Niko Cvjetković
Publication date: 01-12-2008
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2008
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/1752-1947-2-278

At a glance: The STEP trials

Springer Medicine

Radiofrequency-induced thermotherapy of nasopharyngeal angiofibroma and immunohistochemical analysis of vessel proliferation: a case report

Abstract

Introduction

Case presentation

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Case presentation

Conclusion

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