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Open Access 01-12-2014 | Preliminary research

Radiation dosimetry of florbetapir F 18

Authors: Abhinay D Joshi, Michael J Pontecorvo, Lee Adler, Michael G Stabin, Daniel M Skovronsky, Alan P Carpenter, Mark A Mintun, Florbetapir F 18 study investigators

Published in: EJNMMI Research | Issue 1/2014

Abstract

Background

Florbetapir is one of several ¹⁸F-labeled amyloid plaque imaging tracers for positron emission tomography (PET). As the bio-distribution and radiation dose of PET tracers in human research are important for estimating the relative risks and benefits, a study was conducted to obtain this information on florbetapir.

Methods

Nine cognitively normal subjects (six females and three males, age 58 ± 10 years, weight 81 ± 17 kg) received an intravenous bolus injection of 395 ± 27.9 MBq of florbetapir, and whole-body emission scans were performed over approximately 6 h. Computed tomography scans were acquired for attenuation correction. Volumes of interest (VOIs) for source organs including the brain, liver, lung, heart wall, and vertebrae were defined on the PET images. The VOIs of the gallbladder, urinary bladder, and large and small intestines were also defined. Using reference man organ volumes (ICRP 30), total activity was calculated per organ for each time point. The resultant time-activity curves (TACs) were fitted with constrained exponentials. Kinetic data were entered into OLINDA/EXM software to calculate dose estimates; the dynamic urinary bladder and ICRP 30 GI tract models were employed. The effective dose (ED) for each subject was estimated from the acquired data using the adult model.

Results

The mean ED determined for nine healthy volunteers was 18.60 ± 4.26 μSv/MBq or 6.88 mSv for a 370-MBq dose. The organs that received the highest radiation absorbed doses were the gallbladder, upper large intestine, small intestine, liver, and urinary bladder at 143.0 ± 80.20, 74.50 ± 34.20, 65.50 ± 29.60, 64.40 ± 22.10, and 27.10 ± 11.70 μSv/MBq, respectively.

Conclusions

The ED for florbetapir has been calculated for nine healthy volunteers. At a dose of 370 MBq florbetapir, the total average ED is approximately 6.88 mSv.

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The National Institute on Aging and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment Of Alzheimer’s Disease: Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. Neurobiol Aging 1997, 18: S1-S2.CrossRef

Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergström M, Savitcheva I, Huang GF, Estrada S, Ausén B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G, Mathis CA, Långström BJ: Imaging brain amyloid in Alzheimer's disease with Pittsburg Compound-B. Ann Neurol 2004, 55: 306–319. 10.1002/ana.20009CrossRefPubMed

Nordberg A, Rinne JO, Kadir A, Långström B: The use of PET in Alzheimer disease. Nat Rev Neurol 2010, 6(2):78–87. 10.1038/nrneurol.2009.217CrossRefPubMed

Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Mathis CA: Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain. Life Sci 2001, 69(13):1471–1484. 10.1016/S0024-3205(01)01232-2CrossRefPubMed

Rowe CC, Villemagne VL: Brain amyloid imaging. J Nucl Med 2011, 52(11):1733. 1740PubMed

Choi SR, Golding G, Zhuang Z, Zhang W, Lim N, Hefti F, Benedum TE, Kilbourn MR, Skovronsky D, Kung HF: Preclinical properties of ¹⁸F-AV-45: a PET agent for Aβ plaques in the brain. J Nucl Med 2009, 50: 1887–1894. 10.2967/jnumed.109.065284PubMedCentralCrossRefPubMed

Wong DF, Rosenberg PB, Zhou Y, Kumar A, Raymont V, Ravert HT, Dannals RF, Nandi A, Brasić JR, Ye W, Hilton J, Lyketsos C, Kung HF, Joshi AD, Skovronsky DM, Pontecorvo MJ: In vivo imaging of amyloid deposition in Alzheimer's disease using the novel radioligand ¹⁸F-AV-45 (florbetapir F 18). J Nucl Med 2010, 51(6):913–920. 10.2967/jnumed.109.069088PubMedCentralCrossRefPubMed

Clark CM, Schneider JA, Bedell BJ, Beach TG, Bilker WB, Mintun MA, Pontecorvo MJ, Hefti F, Carpenter AP, Flitter ML, Krautkramer MJ, Kung HF, Coleman RE, Doraiswamy PM, Fleisher AS, Sabbagh MN, Sadowsky CH, Reiman EP, Zehntner SP, Skovronsky DM, AV45-A07 Study Group: Use of florbetapir-PET for imaging β-amyloid pathology. JAMA 2011, 305(3):275–283. 10.1001/jama.2010.2008CrossRefPubMed

Clark CM, Pontecorvo MJ, Beach TG, Bedell BJ, Coleman RE, Doraiswamy PM, Fleisher AS, Reiman EM, Sabbagh MN, Sadowsky CH, Schneider JA, Arora A, Carpenter AP, Flitter ML, Joshi AD, Krautkramer MJ, Lu M, Mintun MA, Skovronsky DM, AV-45-A16 Study Group: Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-β plaques: a prospective cohort study. Lancet Neurol 2012, 11(8):669–678. 10.1016/S1474-4422(12)70142-4CrossRefPubMed

10.

Rohen JK, Yokochi C: Color Atlas of Anatomy: A Photographic Study of the Human Body. 3rd edition. New York: Igaku-Shoin; 1992.

11.

Netter FH: Atlas of Human Anatomy. Dover: Ciba-Geigy Corporation; 1989.

12.

Foster DM, Barrett PHR: Developing and testing integrated multi-compartmental models to describe a single-input multiple-output study using the SAAM II software system. In Mathematical Modeling of Experimental Nutrition. Edited by: Clifford AJ. New York: Plenum; 1998:59–78.CrossRef

13.

Stabin MG, Siegel JA: Physical models and dose factors for use in internal dose assessment. Health Phys 2003, 85: 294–310. 10.1097/00004032-200309000-00006CrossRefPubMed

14.

Stabin MG, Sparks RB, Crowe E: OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine. J Nucl Med 2005, 46: 1023–1027.PubMed

15.

International Commission on Radiological Protection: Radiation Dose to Patients from Radiopharmaceuticals. ICRP Publication 106: Addendum 3 to Publication 53. Oxford: Pergamon; 1998.

16.

Lin KJ, Hsu WC, Hsiao IT, Wey SP, Jin LW, Skovronsky D, Wai YY, Chang HP, Lo CW, Yao CH, Yen TC, Kung MP: Whole-body distribution and brain PET imaging with [¹⁸F]AV-45, a novel amyloid imaging agent—a pilot study. Nucl Med Biol 2010, 37: 497–508. 10.1016/j.nucmedbio.2010.02.003CrossRefPubMed

17.

Koole M, Lewis D, Buckley C, Nelissen N, Vandenbulcke M, Brooks D, Vandenberghe R, Van Laere K: Whole-body biodistribution and radiation dosimetry of ¹⁸F-GEo67: a radioligand for in vivo brain amyloid imaging. J Nucl Med 2009, 50: 818–822. 10.2967/jnumed.108.060756CrossRefPubMed

18.

O’Keefe G, Saunder TH, Steven Ng, Ackerman UWE, Tochon-Danguy HJ, Chan GJ, Gong S, Dyrk T, Lindemann S, Holl G, Dinkelborg L, Villemagne V, Rowe CC: Radiation dosimetry of β-amyloid tracers ¹¹C-PIB and ¹⁸F-BAY94–9172. J Nucl Med 2009, 50: 309–315. 10.2967/jnumed.108.055756CrossRefPubMed

19.

Hays MT, Segall GM: A mathematical model for the distribution of fluorodeoxyglucose in humans. J Nucl Med 1999, 40: 1358–1366.PubMed

20.

Deloar HM, Fujiwara T, Shidahara M, Nakamura T, Watabe H, Narita Y, Itoh M, Miyake M, Watanuki S: Estimation of absorbed dose for 2-[F-18] fluoro-2-deoxy-D-glucose using whole-body positron emission tomography and magnetic resonance imaging. Eur J Nucl Med 1998, 25: 565–574. 10.1007/s002590050257CrossRefPubMed

21.

Mejia AA, Nakamura T, Masatoshi I, Hatazawa J, Masaki M, Watanuki S: Estimation of absorbed doses in humans due to intra-venous administration of fluorine-18-fluorodeoxyglucose in PET studies. J Nucl Med 1991, 32: 699–706.PubMed

Title: Radiation dosimetry of florbetapir F 18
Authors: Abhinay D Joshi
Michael J Pontecorvo
Lee Adler
Michael G Stabin
Daniel M Skovronsky
Alan P Carpenter
Mark A Mintun
Florbetapir F 18 study investigators
Publication date: 01-12-2014
Publisher: Springer Berlin Heidelberg
Published in: EJNMMI Research / Issue 1/2014
Electronic ISSN: 2191-219X
DOI: https://doi.org/10.1186/2191-219X-4-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Radiation dosimetry of florbetapir F 18

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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