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Current Sleep Medicine Reports

06-05-2024 | Quetiapine | REVIEW

Effects of Mood Stabilizers on Sleep and Circadian Rhythms: A Systematic Review

Authors: Valerio Caruso, Pierre A. Geoffroy, Gaspare Alfì, Mario Miniati, Dieter Riemann, Angelo Gemignani, Laura Palagini

Published in: Current Sleep Medicine Reports

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Abstract

Purpose of Review

Mood disorders tend to be recurrent, chronic, and disabling, caused by a complex interplay of factors. Within this context, sleep, which is crucial for mental health, may contribute to mental disorders, including mood disorders. Sleep disturbances can serve as risk factors for the onset, exacerbation, and relapse of mood disorders. Treatments for mood disorders should ideally normalize sleep disturbances or may act on mood symptoms through sleep regulation. In this context, the present work aims to systematically review the effects on sleep of mood stabilizers such as lithium as well as carbamazepine, lamotrigine, olanzapine, quetiapine, and valproate.

Recent Findings

A systematic review was implemented to draw useful insights from the literature on the drugs chosen. A total of 85 studies were retained after meeting the inclusion/exclusion criteria. The largest amount of evidence is for lithium as a potential regulator of sleep and circadian rhythm systems. Although fewer studies have been conducted on valproate, it is also emerging as a potential regulator of the sleep and circadian systems. Conversely, more studies are needed for other mood stabilizers such as lamotrigine, carbamazepine, quetiapine, and olanzapine.

Summary

First-generation mood stabilizers like lithium and valproate may exert a regulating role on sleep and circadian systems, demonstrating a tendency to normalize sleep disturbances associated with mood disorders. It is possible that their impact on mood regulation occurs through the regulation of the sleep and circadian systems.
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Metadata
Title
Effects of Mood Stabilizers on Sleep and Circadian Rhythms: A Systematic Review
Authors
Valerio Caruso
Pierre A. Geoffroy
Gaspare Alfì
Mario Miniati
Dieter Riemann
Angelo Gemignani
Laura Palagini
Publication date
06-05-2024
Publisher
Springer International Publishing
Published in
Current Sleep Medicine Reports
Electronic ISSN: 2198-6401
DOI
https://doi.org/10.1007/s40675-024-00298-5