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European Radiology
Published in: European Radiology 4/2017

01-04-2017 | Cardiac

Quantification of global myocardial function by cine MRI deformable registration-based analysis: Comparison with MR feature tracking and speckle-tracking echocardiography

Authors: Mariana M. Lamacie, Paaladinesh Thavendiranathan, Kate Hanneman, Andreas Greiser, Marie-Pierre Jolly, Richard Ward, Bernd J. Wintersperger

Published in: European Radiology | Issue 4/2017

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Abstract

Objectives

To evaluate deformable registration algorithms (DRA)-based quantification of cine steady-state free-precession (SSFP) for myocardial strain assessment in comparison with feature-tracking (FT) and speckle-tracking echocardiography (STE).

Methods

Data sets of 28 patients/10 volunteers, undergoing same-day 1.5T cardiac MRI and echocardiography were included. LV global longitudinal (GLS), circumferential (GCS) and radial (GRS) peak systolic strain were assessed on cine SSFP data using commercially available FT algorithms and prototype DRA-based algorithms. STE was applied as standard of reference for accuracy, precision and intra-/interobserver reproducibility testing.

Results

DRA showed narrower limits of agreement compared to STE for GLS (-4.0 [-0.9,-7.9]) and GCS (-5.1 [1.1,-11.2]) than FT (3.2 [11.2,-4.9]; 3.8 [13.9,-6.3], respectively). While both DRA and FT demonstrated significant differences to STE for GLS and GCS (all p<0.001), only DRA correlated significantly to STE for GLS (r=0.47; p=0.006). However, good correlation was demonstrated between MR techniques (GLS:r=0.74; GCS:r=0.80; GRS:r=0.45, all p<0.05). Comparing DRA with FT, intra-/interobserver coefficient of variance was lower (1.6 %/3.2 % vs. 6.4 %/5.7 %) and intraclass-correlation coefficient was higher. DRA GCS and GRS data presented zero variability for repeated observations.

Conclusions

DRA is an automated method that allows myocardial deformation assessment with superior reproducibility compared to FT.

Key Points

• Inverse deformable registration algorithms (DRA) allow myocardial strain analysis on cine MRI.
• Inverse DRA demonstrated superior reproducibility compared to feature-tracking (FT) methods.
• Cine MR DRA and FT analysis demonstrate differences to speckle-tracking echocardiography
• DRA demonstrated better correlation with STE than FT for MR-derived global strain data.
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Metadata
Title
Quantification of global myocardial function by cine MRI deformable registration-based analysis: Comparison with MR feature tracking and speckle-tracking echocardiography
Authors
Mariana M. Lamacie
Paaladinesh Thavendiranathan
Kate Hanneman
Andreas Greiser
Marie-Pierre Jolly
Richard Ward
Bernd J. Wintersperger
Publication date
01-04-2017
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 4/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4514-0

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