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Supportive Care in Cancer
Published in: Supportive Care in Cancer 2/2017

01-02-2017 | Original Article

Quality of life trajectories after diagnosis of gynecologic cancer: a theoretically based approach

Authors: Brian D. Gonzalez, Sharon L. Manne, Jerod Stapleton, Shannon Myers-Virtue, Melissa Ozga, David Kissane, Carolyn Heckman, Mark Morgan

Published in: Supportive Care in Cancer | Issue 2/2017

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Abstract

Purpose

The course of quality of life after diagnosis of gynecologic cancer is not well understood. We aimed to identify subgroups of gynecologic cancer patients with distinct trajectories of quality of life outcomes in the 18-month period after diagnosis. We also aimed to determine whether these subgroups could be distinguished by predictors derived from Social-Cognitive Processing Theory.

Methods

Gynecologic cancer patients randomized to usual care as part of a psychological intervention trial (NCT01951807) reported on depressed mood, quality of life, and physical impairment soon after diagnosis and at five additional assessments ending 18 months after baseline. Clinical, demographic, and psychosocial predictors were assessed at baseline, and additional clinical factors were assessed between 6 and 18 months after baseline.

Results

A two-group growth mixture model provided the best and most interpretable fit to the data for all three outcomes. One class revealed subclinical and improving scores for mood, quality of life, and physical function across 18 months. A second class represented approximately 12 % of patients with persisting depression, diminished quality of life, and greater physical disability. Membership of this high-risk subgroup was associated with holding back concerns, more intrusive thoughts, and use of pain medications at the baseline assessment (ps < .05).

Conclusions

Trajectories of quality of life outcomes were identified in the 18-month period after diagnosis of gynecologic cancer. Potentially modifiable psychosocial risk factors were identified that can have implications for preventing quality of life disruptions and treating impaired quality of life in future research.
Literature
1.
Greimel E, Thiel I, Peintinger F, Cegnar I, Pongratz E (2002) Prospective assessment of quality of life of female cancer patients. Gynecol Oncol 85:140–147CrossRefPubMed
2.
Lutgendorf SK, Anderson B, Ullrich P, Johnsen EL, Buller RE, Sood AK, Sorosky JI, Ritchie J (2002) Quality of life and mood in women with gynecologic cancer. Cancer 94:131–140CrossRefPubMed
3.
Roland KB, Rodriguez JL, Patterson JR, Trivers KF (2013) A literature review of the social and psychological needs of ovarian cancer survivors. Psycho-Oncology 22:2408–2418CrossRefPubMed
4.
Creamer M, Burgess P, Pattison P (1990) Cognitive processing in post-trauma reactions: some preliminary findings. Psychol Med 20:597–604CrossRefPubMed
5.
Manne S, Ostroff JS, Winkel G (2007) Social-cognitive processes as moderators of a couple-focused group intervention for women with early stage breast cancer. Health Psychol 26:735CrossRefPubMed
6.
Manne SL, Ostroff J, Winkel G, Grana G, Fox K (2005) Partner unsupportive responses, avoidant coping, and distress among women with early stage breast cancer: patient and partner perspectives. Health Psychol 24:635CrossRefPubMed
7.
Dakof GA, Taylor SE (1990) Victims' perceptions of social support: what is helpful from whom? J Pers Soc Psychol 58:80CrossRefPubMed
8.
Koopman C, Hermanson K, Diamond S, Angell K, Spiegel D (1998) Social support, life stress, pain and emotional adjustment to advanced breast cancer. Psycho-Oncology 7:101–111CrossRefPubMed
9.
Norton TR, Manne SL, Rubin S, Hernandez E, Carlson J, Bergman C, Rosenblum N (2005) Ovarian cancer patients' psychological distress: the role of physical impairment, perceived unsupportive family and friend behaviors, perceived control, and self-esteem. Health Psychol 24:143CrossRefPubMed
10.
11.
12.
Manne S, Badr H, Zaider T, Nelson C, Kissane D (2010) Cancer-related communication, relationship intimacy, and psychological distress among couples coping with localized prostate cancer. J Cancer Surviv 4:74–85CrossRefPubMed
13.
Lepore SJ (2001) A social–cognitive processing model of emotional adjustment to cancer. In: Baum A, Andersen B (eds) Psychological interventions for cancer. American Psychological Association, Washington, D.C., pp. 99–116CrossRef
14.
Figueiredo MI, Fries E, Ingram KM (2004) The role of disclosure patterns and unsupportive social interactions in the well-being of breast cancer patients. Psycho-Oncology 13:96–105CrossRefPubMed
15.
Porter LS, Keefe FJ, Hurwitz H, Faber M (2005) Disclosure between patients with gastrointestinal cancer and their spouses. Psycho-Oncology 14:1030–1042CrossRefPubMed
16.
Myers SB, Manne SL, Kissane DW, Ozga M, Kashy DA, Rubin S, Heckman C, Rosenblum N, Morgan M, Graff JJ (2013) Social–cognitive processes associated with fear of recurrence among women newly diagnosed with gynecological cancers. Gynecol Oncol 128:120–127CrossRefPubMed
17.
Lutgendorf SK, Anderson B, Rothrock N, Buller RE, Sood AK, Sorosky JI (2000) Quality of life and mood in women receiving extensive chemotherapy for gynecologic cancer. Cancer 89:1402–1411CrossRefPubMed
18.
Costanzo ES, Lutgendorf SK, Rothrock NE, Anderson B (2006) Coping and quality of life among women extensively treated for gynecologic cancer. Psycho-Oncology 15:132–142CrossRefPubMed
19.
Donovan KA, Gonzalez BD, Small BJ, Andrykowski MA, Jacobsen PB (2013) Depressive symptom trajectories during and after adjuvant treatment for breast cancer. Ann Behav Med 47:292–302CrossRef
20.
Zhou Y, Irwin ML, Ferrucci LM, McCorkle R, Ercolano EA, Li F, Stein K, Cartmel B (2016) Health-related quality of life in ovarian cancer survivors: results from the American Cancer Society's study of cancer survivors—I. Gynecol Oncol 141:543–549CrossRefPubMed
21.
Zeng Y, Cheng A, Liu X, Feuerstein M (2016) Symptom profiles, work productivity and quality of life among Chinese female cancer survivors. Gynecology & Obstetrics 6:2161CrossRef
22.
Mirabeau-Beale KL, Kornblith AB, Penson RT, Lee H, Goodman A, Campos SM, Duska L, Pereira L, Bryan J, Matulonis UA (2009) Comparison of the quality of life of early and advanced stage ovarian cancer survivors. Gynecol Oncol 114:353–359CrossRefPubMed
23.
Teng FF, Kalloger SE, Brotto L, McAlpine JN (2014) Determinants of quality of life in ovarian cancer survivors: a pilot study. J Obstet Gynaecol Can 36:708–715CrossRefPubMed
24.
Ahmed-Lecheheb D, Joly F (2016) Ovarian cancer survivors’ quality of life: a systematic review. J Cancer Surviv 10:1–13CrossRef
25.
Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:561CrossRefPubMed
26.
Avis NE, Levine BJ, Case LD, Naftalis EZ, Van Zee KJ (2015) Trajectories of depressive symptoms following breast cancer diagnosis. Cancer Epidemiol Biomark Prev 24:1789–1795CrossRef
27.
Beck AT, Steer RA, Carbin MG (1988) Psychometric properties of the Beck depression inventory: twenty-five years of evaluation. Clin Psychol Rev 8:77–100CrossRef
28.
Norman GR, Sloan JA, Wyrwich KW (2003) Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Med Care 41:582–592PubMed
29.
Cella DF, Tulsky DS, Gray G, Sarafian B, Linn E, Bonomi A, Silberman M, Yellen SB, Winicour P, Brannon J et al (1993) The functional assessment of cancer therapy scale: development and validation of the general measure. J Clin Oncol 11:570–579PubMed
30.
Ledermann J, Harter P, Gourley C, Friedlander M, Vergote I, Rustin G, Scott C, Meier W, Shapira-Frommer R, Safra T (2012) Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer. N Engl J Med 366:1382–1392CrossRefPubMed
31.
Stafford L, Foley E, Judd F, Gibson P, Kiropoulos L, Couper J (2013) Mindfulness-based cognitive group therapy for women with breast and gynecologic cancer: a pilot study to determine effectiveness and feasibility. Support Care Cancer 21:3009–3019CrossRefPubMed
32.
McCarroll M, Armbruster S, Frasure H, Gothard M, Gil K, Kavanagh M, Waggoner S, von Gruenigen V (2014) Self-efficacy, quality of life, and weight loss in overweight/obese endometrial cancer survivors (SUCCEED): a randomized controlled trial. Gynecol Oncol 132:397–402CrossRefPubMed
33.
Yost KJ, Eton DT (2005) Combining distribution-and anchor-based approaches to determine minimally important differences the FACIT experience. Evaluation & the Health Professions 28:172–191CrossRef
34.
Brucker PS, Yost K, Cashy J, Webster K, Cella D (2005) General population and cancer patient norms for the functional assessment of cancer therapy-general (FACT-G). Evaluation & the Health Professions 28:192–211CrossRef
35.
Ganz P, Schag C, Lee J, Sim M-S (1992) The CARES: a generic measure of health-related quality of life for patients with cancer. Qual Life Res 1:19–29CrossRefPubMed
36.
Hawighorst-Knapstein S, Schönefußrs G, Hoffmann SO, Knapstein PG (1997) Pelvic exenteration: effects of surgery on quality of life and body image—a prospective longitudinal study. Gynecol Oncol 66:495–500CrossRefPubMed
37.
Boehmer U, Glickman M, Winter M, Clark MA (2014) Coping and benefit finding among long-term breast cancer survivors of different sexual orientations. Women & Therapy 37:222–241CrossRef
38.
Manne S, Schnoll R (2001) Measuring supportive and unsupportive responses during cancer treatment: a factor analytic assessment of the partner responses to cancer inventory. J Behav Med 24:297–321CrossRefPubMed
39.
Antoni MH, Lehman JM, Kilbourn KM, Boyers AE, Culver JL, Alferi SM, Yount SE, McGregor BA, Arena PL, Harris SD (2001) Cognitive-behavioral stress management intervention decreases the prevalence of depression and enhances benefit finding among women under treatment for early-stage breast cancer. Health Psychol 20:20CrossRefPubMed
40.
Tomich PL, Helgeson VS (2004) Is finding something good in the bad always good? Benefit finding among women with breast cancer. Health Psychol 23:16CrossRefPubMed
41.
Horowitz M, Wilner N, Alvarez W (1979) Impact of event scale: a measure of subjective stress. Psychosom Med 41:209–218CrossRefPubMed
42.
Carver CS, Scheier MF, Weintraub JK (1989) Assessing coping strategies: a theoretically based approach. J Pers Soc Psychol 56:267CrossRefPubMed
43.
Ram N, Grimm KJ (2009) Methods and measures: growth mixture modeling: a method for identifying differences in longitudinal change among unobserved groups. Int J Behav Dev 33:565–576CrossRefPubMedPubMedCentral
44.
Manne SL, Norton TR, Ostroff JS, Winkel G, Fox K, Grana G (2007) Protective buffering and psychological distress among couples coping with breast cancer: the moderating role of relationship satisfaction. J Fam Psychol 21:380CrossRefPubMed
45.
Harding S, Sanipour F, Moss T (2014) Existence of benefit finding and posttraumatic growth in people treated for head and neck cancer: a systematic review. Peer J 2:e256CrossRefPubMedPubMedCentral
46.
Carver CS, Antoni MH (2004) Finding benefit in breast cancer during the year after diagnosis predicts better adjustment 5 to 8 years after diagnosis. Health Psychol 23:595CrossRefPubMed
47.
Wang Y, Zhu X, Yi J, Tang L, He J, Chen G, Li L, Yang Y (2015) Benefit finding predicts depressive and anxious symptoms in women with breast cancer. Qual Life Res 24:2681–2688CrossRefPubMed
48.
Costa RV, Pakenham KI (2012) Associations between benefit finding and adjustment outcomes in thyroid cancer. Psycho-Oncology 21:737–744CrossRefPubMed
49.
50.
Jansen L, Koch L, Brenner H, Arndt V (2010) Quality of life among long-term (⩾ 5 years) colorectal cancer survivors—systematic review. Eur J Cancer 46:2879–2888CrossRefPubMed
51.
Tickoo RS, Key RG, Breitbart WS (2015) Cancer-related pain. In: Holland JC, Breitbart WS, Butow PN, Jacobsen PB, Loscalzo MJ, McCorkle R (eds) Psycho-oncology. Oxford University Press, New York, pp. 171–198
Metadata
Title
Quality of life trajectories after diagnosis of gynecologic cancer: a theoretically based approach
Authors
Brian D. Gonzalez
Sharon L. Manne
Jerod Stapleton
Shannon Myers-Virtue
Melissa Ozga
David Kissane
Carolyn Heckman
Mark Morgan
Publication date
01-02-2017
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 2/2017
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-016-3443-4

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