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Quality of Life Research
Published in: Quality of Life Research 7/2016

Open Access 01-07-2016

Quality of life increases in patients with painful diabetic neuropathy following treatment with spinal cord stimulation

Authors: Rui V. Duarte, Lazaros Andronis, Mathieu W. P. M. Lenders, Cecile C. de Vos

Published in: Quality of Life Research | Issue 7/2016

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Abstract

Purpose

This study aims to explore the changes in pain intensity and quality of life (QoL) experienced by patients with painful diabetic neuropathy (PDN) treated with spinal cord stimulation (SCS) and conventional medical practice (CMP).

Methods

Patient-reported pain intensity and QoL data were obtained from participants in an international multicentre randomised controlled trial comparing SCS versus CMP. Data were collected at randomisation and 6 month follow up by means of a visual analogue scale for pain intensity, the EuroQoL Visual Analogue Scale (EQ VAS) and the EuroQol EQ-5D index. Quality-adjusted life years (QALYs) were calculated for each treatment using the ‘area under the curve’ method. Differences in QALYs were calculated after adjusting for between-treatment imbalances in baseline QoL.

Results

At 6 months, patients allocated to SCS reported larger reductions in pain intensity and improvements in QoL measured by the EQ-5D utility score and EQ VAS as compared to those allocated to CMP. Initial calculations of QALYs for the SCS and CMP groups suggested no statistical differences between the groups. Adjusting for imbalances in baseline EQ-5D scores showed SCS to be associated with significantly higher QALYs compared to CMP.

Conclusions

SCS resulted in significant improvement in pain intensity and QoL in patients with PDN, offering further support for SCS as an effective treatment for patients suffering from PDN. From a methodological point of view, different results would have been obtained if QALY calculations were not adjusted for baseline EQ-5D scores, highlighting the need to account for imbalances in baseline QoL.
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Metadata
Title
Quality of life increases in patients with painful diabetic neuropathy following treatment with spinal cord stimulation
Authors
Rui V. Duarte
Lazaros Andronis
Mathieu W. P. M. Lenders
Cecile C. de Vos
Publication date
01-07-2016
Publisher
Springer International Publishing
Published in
Quality of Life Research / Issue 7/2016
Print ISSN: 0962-9343
Electronic ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-015-1211-4

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