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Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2010

Open Access 01-12-2010 | Research

Quality of life in colon cancer patients with skin side effects: preliminary results from a monocentric cross sectional study

Authors: Federica Andreis, Anna Rizzi, Paola Mosconi, Claudia Braun, Luigina Rota, Fausto Meriggi, Maria Mazzocchi, Alberto Zaniboni

Published in: Health and Quality of Life Outcomes | Issue 1/2010

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Abstract

Background

Epidermal growth factor receptor inhibitors are widely prescribed anticancer drugs. Patients treated commonly develop dermatologic adverse drugs reactions, but rarely they are involved in systematic evaluation of their quality of life. This monocentric cross sectional study is carried out to assess quality of life in colon cancer patients experienced skin side effects due to anti epidermal growth factor receptor inhibitors therapy.

Methods

Consecutive patients with skin side effects to therapy treated at Fondazione Poliambulanza were enrolled in this study. Quality of life was evaluated with the Italian validated version of Skindex-29 questionnaire, exploring three dimensions: symptoms, emotional, and physical functioning. Skindex-29 was administered one time between the eighth and the twelfth week of the treatment.

Results

Forty-five consecutive patients, mainly with metastatic colon cancer (29 female, 16 male), with an average age of 59.31 years (ranging from 34-78) were included in the study and analyzed. Patients showed a great impact of skin side effects on symptoms (mean 43), followed by emotional (mean 30), and functioning (mean 26) scales. In general women, the 55-65 age class, and patients with partial remission reported the worst quality of life.

Conclusions

Epidermal growth factor receptor inhibitors' skin side effects have an important impact on quality of life in advanced colon cancer patients; symptoms scale is the most effect respect to emotional and functioning scales.
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Metadata
Title
Quality of life in colon cancer patients with skin side effects: preliminary results from a monocentric cross sectional study
Authors
Federica Andreis
Anna Rizzi
Paola Mosconi
Claudia Braun
Luigina Rota
Fausto Meriggi
Maria Mazzocchi
Alberto Zaniboni
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2010
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-8-40

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