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BMC Neurology
Published in: BMC Neurology 1/2010

Open Access 01-12-2010 | Research article

Quality of life in childhood epilepsy with lateralized epileptogenic foci

Authors: Krystyna A Mathiak, Małgorzata Łuba, Klaus Mathiak, Katarzyna Karzel, Tomasz Wolańczyk, Elżbieta Szczepanik, Paweł Ostaszewski

Published in: BMC Neurology | Issue 1/2010

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Abstract

Background

Measuring quality of life (QOL) helps to delineate mechanisms underlying the interaction of disease and psychosocial factors. In adults, epileptic foci in the left temporal lobe led to lower QOL and higher depression and anxiety as compared to the right-sided foci. No study addressed the development of QOL disturbances depending on the lateralization of epileptogenic focus. The objective of our study was to examine QOL in children with lateralized epileptiform discharges.

Methods

Thirty-one parents of children with epilepsy filled the Health-Related Quality of Life in Childhood Epilepsy Questionnaire (QOLCE). Fifteen children had foci in the left hemisphere and sixteen in the right, as verified with Electroencephalography (EEG) examinations.

Results

We found a significant correlation between foci lateralization and reduced QOL (Spearman's rho = 0.361, p < 0.046). Children with right hemispheric foci exhibited lower overall QOL, particularly in five areas: anxiety, social-activities, stigma, general-health, and quality-of-life.

Conclusions

We demonstrated for the first time that in children left- and right-hemispheric foci were associated with discordant QOL scores. Unlike in adults, foci in the right hemisphere led to worse emotional and social functioning demonstrating that seizures impact the brain differentially during development.
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Metadata
Title
Quality of life in childhood epilepsy with lateralized epileptogenic foci
Authors
Krystyna A Mathiak
Małgorzata Łuba
Klaus Mathiak
Katarzyna Karzel
Tomasz Wolańczyk
Elżbieta Szczepanik
Paweł Ostaszewski
Publication date
01-12-2010
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2010
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/1471-2377-10-69

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