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01-02-2011

Qi-Shao-Shuang-Gan, a Combination of Astragalus membranaceus Saponins with Paeonia lactiflora Glycosides, Ameliorates Polymicrobial Sepsis Induced by Cecal Ligation and Puncture in Mice

Authors: Xing-hua Gao, Xian-xiang Xu, Rong Pan, Chong Wang, Rong Sheng, Yu-feng Xia, Yue Dai

Published in: Inflammation | Issue 1/2011

Abstract

The present study was performed to investigate the anti-septic effects of Qi-Shao-Shuang-Gan (QSSG), a combination of Astragalus membranaceus saponins (SAM) and Paeonia lactiflora glycosides (GPL), in septic mice induced by cecal ligation and puncture. QSSG was shown to elevate the survival rate of mice, decrease infiltration of polymorphonuclear leukocytes into livers and lungs, lower serum levels of myeloperoxidase, nitric oxide, and lactate dehydrogenase, and decrease mRNA expressions of inducible nitric oxide synthase and interleukin-1β in livers. It also restored the impaired expressions of protein C (PC) mRNA in mouse livers and expressions of thrombomodulin and endothelial PC receptor mRNA in endothelial cells. Neither SAM nor GPL alone could significantly increase the survival rate of septic mice. The findings indicate that QSSG exerts protective action against polymicrobial sepsis by inhibiting systemic inflammatory response and upregulating PC pathway, and there are synergistic effects between SAM and GPL.

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Title: Qi-Shao-Shuang-Gan, a Combination of Astragalus membranaceus Saponins with Paeonia lactiflora Glycosides, Ameliorates Polymicrobial Sepsis Induced by Cecal Ligation and Puncture in Mice
Authors: Xing-hua Gao
Xian-xiang Xu
Rong Pan
Chong Wang
Rong Sheng
Yu-feng Xia
Yue Dai
Publication date: 01-02-2011
Publisher: Springer US
Published in: Inflammation / Issue 1/2011
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-010-9202-7

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