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Open Access 01-11-2013 | Meeting abstract

PW01-035 – Mutations in PB30.2D and complexing with caspase-1

Authors: K Nazaryan, G Arakelov

Published in: Pediatric Rheumatology | Special Issue 1/2013

Excerpt

Mutations M680I, M694V and V726A of Pyrin - the product of MEFV gene - are localized at the domain B30.2 (PB30.2D) and responsible for manifestation of the most widespread and severe forms of FMF. From the other hand, it is well known that malfunction of the pyrin-caspase-1complex is the main reason for inflammation during FMF. Therefore, we suggest that comparative investigation of normal and mutated pyrin and caspase-1 interaction will help to reveal possible link between those mutations and structural changes that influence formation of pyrin-caspase-1 complex. …

Title: PW01-035 – Mutations in PB30.2D and complexing with caspase-1
Authors: K Nazaryan
G Arakelov
Publication date: 01-11-2013
Publisher: BioMed Central
Published in: Pediatric Rheumatology / Issue Special Issue 1/2013
Electronic ISSN: 1546-0096
DOI: https://doi.org/10.1186/1546-0096-11-S1-A88

Keynote webinar | Spotlight on medication adherence

Springer Medicine

PW01-035 – Mutations in PB30.2D and complexing with caspase-1

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

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