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01-10-2015 | Neurology and Preclinical Neurological Studies - Original Article

Putaminal alteration in multiple sclerosis patients with spinal cord lesions

Authors: Hilga Zimmermann, Hans O. Rolfsnes, Swantje Montag, Janine Wilting, Amgad Droby, Eva Reuter, Joachim Gawehn, Frauke Zipp, Adriane Gröger

Published in: Journal of Neural Transmission | Issue 10/2015

Abstract

Typical multiple sclerosis (MS) lesions occur in the brain as well as in the spinal cord. However, two extreme magnetic resonance imaging phenotypes appear occasionally: those with predominantly spinal cord lesions (MS + SL) and those with cerebral lesions and no detectable spinal lesions (MS + CL). We assessed whether morphological differences can be found between these two extreme phenotypes. We examined 19 patients with MS + SL, 18 with MS + CL and 20 controls. All subjects were examined using magnetic resonance imaging, including anatomical and diffusion tensor imaging sequences. Voxel-based morphologic and regions of interest-based analyses and tract-based spatial statistics were performed. Patients also underwent neuropsychological testing. Demographic, clinical and neuropsychological characteristics did not differ between MS + SL and MS + CL patients. Patients with MS + SL showed significantly larger putamen volumes than those with MS + CL which correlated negatively with disability. Compared to controls, only MS + CL revealed clear cortical and deep gray matter atrophy, which correlated with cerebral lesion volume. Additionally, extensive white matter microstructural damage was found only in MS + CL compared to MS + SL and controls in the tract-based spatial statistics. Higher putamen volumes in MS + SL could suggest compensatory mechanisms in this area responsible for motor control. Widely reduced fractional anisotropy values in MS + CL were caused by higher cerebral lesion volume and thus presumably stronger demyelination, which subsequently leads to higher global gray matter atrophy.

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Title: Putaminal alteration in multiple sclerosis patients with spinal cord lesions
Authors: Hilga Zimmermann
Hans O. Rolfsnes
Swantje Montag
Janine Wilting
Amgad Droby
Eva Reuter
Joachim Gawehn
Frauke Zipp
Adriane Gröger
Publication date: 01-10-2015
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 10/2015
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-015-1406-4

At a glance: The STEP trials

Springer Medicine

Putaminal alteration in multiple sclerosis patients with spinal cord lesions

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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