Top

Journal of Cardiothoracic Surgery

Published in:

Open Access 01-12-2017 | Case report

Pulmonary inflammatory Myofibroblastic tumor indistinguishable from tuberculosis: a case report in a five-year-old child with hemoptysis

Authors: Tao Zuo, Jun Fu, Zhengyi Ni, Baojun Chen

Published in: Journal of Cardiothoracic Surgery | Issue 1/2017

Abstract

Background

Pulmonary inflammatory myofibroblastic tumor (PIMT) is a rare disease in China and its incidence is much lower than that of tuberculosis. PIMT accounts for only 0.04–1.2% of all lung tumors. PIMT can occurs in any age and nearly every part of the body. The clinical symptoms and radiological features of PIMT are nonspecific. Diagnosis is only made on the basis of histopathologic or immunohistochemical evaluation of the postoperation resected tissue. The therapeutic approach to PIMT should rely mainly on complete surgical resection.

Case presentation

We report a case of PIMT with hemoptysis. The girl was misdiagnosed with tuberculosis and treated with anti-tuberculous drugs for a long period of time. A right upper and middle lobectomy was performed and further assessment of the tissue demonstrated a pathologic diagnosis of PIMT.

Conclusions

Despite a high incidence of tuberculosis, we must consider the possibility of PIMTs in such cases to prevent misdiagnosis and mistreatment.

Coffin CM, Hornick JL, Fletcher CD. Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases. Am J Surg Pathol. 2007;31:509–20.

Zhang Y, Dong ZJ, Zhi XY, Liu L, Inflammatory HM. Myofibroblastic tumor in lung with osteopulmonary arthropathy. Chin Med J. 2009 Dec 20;122(24):3094–6.PubMed

LoefflerRagg J, Bodner J, Freund M, Steurer M, Uprimny C, Zelger B, Kähler CM. Diagnostic and Therapeutic Challenges of a Large Pleural Inflammatory Myofibroblastic Tumor. Case Reports in Pulmonology. 2012;2012:102196.

Hammas N, Chbani L, Rami M, Boubbou M, Benmiloud S, Bouabdellah Y, Tizniti S, Hida M, Amarti AA. Rare tumor of the lung: inflammatory myofibroblastic tumor. Diagn Pathol. 2012;7:83.

Brunn H. Two interesting benign lung tumors of contradictory histopathology. J Thorac Surg. 1939;9:119–31.

Li J, Yin WH, Takeuchi K, Guan H, Huang YH, Chan JK. Inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement: a report of two cases and literature review. Diagn Pathol. 2013;8:147.

Kozu Y, Isaka M, Ohde Y, Takeuchi K, Nakajima T. Epithelioid inflammatory myofibroblastic sarcoma arising in the pleural cavity. Gen Thorac Cardiovasc Surg. 2014;62(3):191–4.

Takeda S, Onishi Y, Kawamura T, Maeda H. Clinical spectrum of pulmonary inflammatory myofibroblastic tumor. Interact Cardiovasc Thorac Surg. 2008;7(4):629–33.

Gallego L, Santamarta TR, Blanco V, García-Consuegra L, Cutilli T, Junquera L. Inflammatory myofibroblastic tumor of the lung and the maxillary region: a benign lesion with aggressive behavior. Case Rep Dent. 2013;2013:879792.PubMedPubMedCentral

10.

İçmeli ÖS, Alpay LA, Gündoğuş B, Türker H, Şen A. Inflammatory myofibroblastictumor: a rare tumor of the lung. Eur Clin Respir J. 2014;19:1.

11.

Schweckendiek D, Inci I, Schneiter D, Weder W. Inflammatory Myofibroblastic tumor of the lung: two progressing pulmonary nodules in a 25-year-old adult with a Moraxella catharalis infection. Ann Thorac Surg. 2015;100(6):e123–4.

12.

Yan Q, Inflammatory HXL. Myofibroblastic tumor of the larynx: report of a case and review of the literature. Int J Clin Exp Pathol. 2015;8(10):13557–60.

13.

Hornick JL, Sholl LM, Dal Cin P, Childress MA, Lovly CM. Expression of ROS1 predicts ROS1 gene rearrangement in inflammatory myofibroblastic tumors. Mod Pathol. 2015;28(5):732–9.

14.

Pavithran K, Manoj P, Vidhyadharan G, Shanmughasundaram P. Inflammatory myofibroblastic tumor of the lung: unusual imaging findings. World J Nucl Med. 2013;12(3):126–8.

15.

Wu J, Zhu H, Li K, Yuan CY, Wang YF, Imaging LGM. Observations of pulmonary inflammatory myofibroblastic tumors in patients over 40 years old. Oncol Lett. 2015;9(4):1877–84.

16.

Hussain SF, Salahuddin N, Khan A, Memon SS, Fatimi SH, Ahmed R. The insidious onset of dyspnea and right lung collapse in a 35-year-old man. Chest. 2005;127(5):1844–7.

17.

Brambilla E, Travis WD, Colby TV, Corrin B, Shimosato Y. The new World Health Organization classification of lung tumours. Eur Respir J. 2001;18(6):1059–68. ReviewCrossRefPubMed

18.

Dishop MK, Warner BW, Dehner LP, Kriss VM, Greenwood MF, Geil JD, Moscow JA. Successful treatment of inflammatory myofibroblastic tumor with malignant transformation by surgical resection and chemotherapy. J Pediatr Hematol Oncol. 2003;25(2):153–8. ReviewCrossRefPubMed

19.

Chen CH, Lin RL, Liu HC, Chen CH, Hung TT, Huang WC. Inflammatory myofibroblastic tumor mimicking anterior mediastinal malignancy. Ann Thorac Surg. 2008;86(4):1362–4.

20.

Lee MH, Lee HB, Lee YC, Rhee YK, Lee EJ, Chung MJ, Jin GY, Kweon EY, Park SJ. Bilateral multiple inflammatory myofibroblastic tumors of the lung successfully treated with corticosteroids. Lung. 2011;189(5):433–5.

Title: Pulmonary inflammatory Myofibroblastic tumor indistinguishable from tuberculosis: a case report in a five-year-old child with hemoptysis
Authors: Tao Zuo
Jun Fu
Zhengyi Ni
Baojun Chen
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Journal of Cardiothoracic Surgery / Issue 1/2017
Electronic ISSN: 1749-8090
DOI: https://doi.org/10.1186/s13019-017-0670-9

At a glance: The STEP trials

Springer Medicine

Pulmonary inflammatory Myofibroblastic tumor indistinguishable from tuberculosis: a case report in a five-year-old child with hemoptysis

Abstract

Background

Case presentation

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case presentation

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2017

Xenoantigenicity of porcine decellularized valves

Should high risk patients with concomitant severe aortic stenosis and mitral valve disease undergo double valve surgery in the TAVR era?

Rare association of two cardiovascular malformations successfully corrected in a single surgery: a case report

Concomitant aorto-right subclavian artery bypass with off-pump coronary artery bypass grafting: a case report

Is there a correlation between late re-exploration after cardiac surgery and removal of epicardial pacemaker wires?

Robotic sleeve lobectomy with four arms for lung cancer centrally located in the right lower lobe: a case report