Skip to main content
Top
Published in: Obesity Surgery 3/2021

01-03-2021 | Public Health | Original Contributions

Development and Validation of a Predictive Model of Success in Bariatric Surgery

Authors: Carina A. Blume, Priscila G. Brust-Renck, Miriam K. Rocha, Gabriel Leivas, Jeruza L. Neyeloff, Michel J. Anzanello, Flavio S. Fogliatto, Luciana R. Bahia, Gabriela H. Telo, Beatriz D. Schaan

Published in: Obesity Surgery | Issue 3/2021

Login to get access

Abstract

Purpose

There are no criteria to establish priority for bariatric surgery candidates in the public health system in several countries. The aim of this study is to identify preoperative characteristics that allow predicting the success after bariatric surgery.

Materials and Methods

Four hundred and sixty-one patients submitted to Roux-en-Y gastric bypass were included. Success of the surgery was defined as the sum of five outcome variables, assessed at baseline and 12 months after the surgery: excess weight loss, use of continuous positive airway pressure (CPAP) or bilevel positive airway pressure (BiPAP) as a treatment for obstructive sleep apnea (OSA), daily number of antidiabetics, daily number of antihypertensive drugs, and all-cause mortality. Partial least squares (PLS) regression and multiple linear regression were performed to identify preoperative predictors. We performed a 90/10 split of the dataset in train and test sets and ran a leave-one-out cross-validation on the train set and the best PLS model was chosen based on goodness-of-fit criteria.

Results

The preoperative predictors of success after bariatric surgery included lower age, presence of non-alcoholic fatty liver disease and OSA, more years of CPAP/BiPAP use, negative history of cardiovascular disease, and lower number of antihypertensive drugs. The PLS model displayed a mean absolute percent error of 0.1121 in the test portion of the dataset, leading to accurate predictions of postoperative outcomes.

Conclusion

This success index allows prioritizing patients with the best indication for the procedure and could be incorporated in the public health system as a support tool in the decision-making process.
Appendix
Available only for authorised users
Literature
1.
go back to reference World Health Organization. Noncommunicable Diseases Progress Monitor 2020. Geneva; 2020. Licence: CC BY-NC-SA 3.0 IGO. World Health Organization. Noncommunicable Diseases Progress Monitor 2020. Geneva; 2020. Licence: CC BY-NC-SA 3.0 IGO.
2.
go back to reference Blüher M. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 2019;15(5):288–98.CrossRef Blüher M. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 2019;15(5):288–98.CrossRef
3.
go back to reference Fontaine KR, Redden DT, Wang C, et al. Years of life lost due to obesity. JAMA. 2003;289(2):187–93.CrossRef Fontaine KR, Redden DT, Wang C, et al. Years of life lost due to obesity. JAMA. 2003;289(2):187–93.CrossRef
4.
go back to reference Sheng B, Truong K, Spitler H, et al. The long-term effects of bariatric surgery on type 2 diabetes remission, microvascular and macrovascular complications, and mortality: a systematic review and meta-analysis. Obes Surg. 2017;27(10):2724–32.CrossRef Sheng B, Truong K, Spitler H, et al. The long-term effects of bariatric surgery on type 2 diabetes remission, microvascular and macrovascular complications, and mortality: a systematic review and meta-analysis. Obes Surg. 2017;27(10):2724–32.CrossRef
5.
go back to reference Jakobsen GS, Småstuen MC, Sandbu R, et al. Association of bariatric surgery vs medical obesity treatment with long-term medical complications and obesity-related comorbidities. JAMA. 2018;319(3):291–301.CrossRef Jakobsen GS, Småstuen MC, Sandbu R, et al. Association of bariatric surgery vs medical obesity treatment with long-term medical complications and obesity-related comorbidities. JAMA. 2018;319(3):291–301.CrossRef
6.
go back to reference National Institutes of Health. Gastrointestinal surgery for severe obesity. Consensus Development Conference Panel. Ann Intern Med. 1991;115(12):956–61. National Institutes of Health. Gastrointestinal surgery for severe obesity. Consensus Development Conference Panel. Ann Intern Med. 1991;115(12):956–61.
8.
go back to reference Cohen RV, Luque A, Junqueira S, et al. What is the impact on the healthcare system if access to bariatric surgery is delayed? Surg Obes Relat Dis. 2017;13(9):1619–27. Cohen RV, Luque A, Junqueira S, et al. What is the impact on the healthcare system if access to bariatric surgery is delayed? Surg Obes Relat Dis. 2017;13(9):1619–27.
9.
go back to reference Alvarez R, Bonham AJ, Buda CM, et al. Factors associated with long wait times for bariatric surgery. Ann Surg. 2019;270(6):1103–9.CrossRef Alvarez R, Bonham AJ, Buda CM, et al. Factors associated with long wait times for bariatric surgery. Ann Surg. 2019;270(6):1103–9.CrossRef
10.
go back to reference Arteaga-González IJ, Martín-Malagón AI, Ruiz de Adana JC, et al. Bariatric surgery waiting lists in Spain. Obes Surg. 2018;28(12):3992–6.CrossRef Arteaga-González IJ, Martín-Malagón AI, Ruiz de Adana JC, et al. Bariatric surgery waiting lists in Spain. Obes Surg. 2018;28(12):3992–6.CrossRef
11.
go back to reference Flanagan E, Ghaderi I, Overby DW, et al. Reduced survival in bariatric surgery candidates delayed or denied by lack of insurance approval. Am Surg. 2016;82(2):166–70.CrossRef Flanagan E, Ghaderi I, Overby DW, et al. Reduced survival in bariatric surgery candidates delayed or denied by lack of insurance approval. Am Surg. 2016;82(2):166–70.CrossRef
12.
go back to reference Padwal RS, Klarenbach SW, Wang X, et al. A simple prediction rule for all-cause mortality in a cohort eligible for bariatric surgery. JAMA Surg. 2013;148(12):1109–15.CrossRef Padwal RS, Klarenbach SW, Wang X, et al. A simple prediction rule for all-cause mortality in a cohort eligible for bariatric surgery. JAMA Surg. 2013;148(12):1109–15.CrossRef
13.
go back to reference Padwal RS, Pajewski NM, Allison DB, et al. Using the Edmonton obesity staging system to predict mortality in a population-representative cohort of people with overweight and obesity. CMAJ. 2011;183(14):E1059–66.CrossRef Padwal RS, Pajewski NM, Allison DB, et al. Using the Edmonton obesity staging system to predict mortality in a population-representative cohort of people with overweight and obesity. CMAJ. 2011;183(14):E1059–66.CrossRef
14.
go back to reference DeMaria EJ, Portenier D, Wolfe L. Obesity surgery mortality risk score: proposal for a clinically useful score to predict mortality risk in patients undergoing gastric bypass. Surg Obes Relat Dis. 2007;3(2):134–40.CrossRef DeMaria EJ, Portenier D, Wolfe L. Obesity surgery mortality risk score: proposal for a clinically useful score to predict mortality risk in patients undergoing gastric bypass. Surg Obes Relat Dis. 2007;3(2):134–40.CrossRef
15.
go back to reference Stenberg E, Cao Y, Szabo E, et al. Risk prediction model for severe postoperative complication in bariatric surgery. Obes Surg. 2018;28(7):1869–75.CrossRef Stenberg E, Cao Y, Szabo E, et al. Risk prediction model for severe postoperative complication in bariatric surgery. Obes Surg. 2018;28(7):1869–75.CrossRef
16.
go back to reference Collins GS, Reitsma JB, Altman DG, et al. Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD). Ann Intern Med. 2015;162(10):735–6.CrossRef Collins GS, Reitsma JB, Altman DG, et al. Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD). Ann Intern Med. 2015;162(10):735–6.CrossRef
17.
go back to reference World Health Organization. Physical status: the use and interpretation of anthropometry. WHO Technical Report Series 854. Geneva; 1995. World Health Organization. Physical status: the use and interpretation of anthropometry. WHO Technical Report Series 854. Geneva; 1995.
18.
19.
go back to reference Panunzi S, Carlsson L, De Gaetano A, et al. Determinants of diabetes remission and glycemic control after bariatric surgery. Diabetes Care. 2016;39(1):166–74.CrossRef Panunzi S, Carlsson L, De Gaetano A, et al. Determinants of diabetes remission and glycemic control after bariatric surgery. Diabetes Care. 2016;39(1):166–74.CrossRef
20.
go back to reference Schiavon CA, Bersch-Ferreira AC, Santucci EV, et al. Effects of bariatric surgery in obese patients with hypertension: the GATEWAY randomized trial (Gastric Bypass to Treat Obese Patients With Steady Hypertension). Circulation. 2018;137(11):1132–42.CrossRef Schiavon CA, Bersch-Ferreira AC, Santucci EV, et al. Effects of bariatric surgery in obese patients with hypertension: the GATEWAY randomized trial (Gastric Bypass to Treat Obese Patients With Steady Hypertension). Circulation. 2018;137(11):1132–42.CrossRef
21.
go back to reference Schiavon CA, Bhatt DL, Ikeoka D, et al. Three-year outcomes of bariatric surgery in patients with obesity and hypertension: a randomized clinical trial. Ann Intern Med. 2020;173(9):685–93. Schiavon CA, Bhatt DL, Ikeoka D, et al. Three-year outcomes of bariatric surgery in patients with obesity and hypertension: a randomized clinical trial. Ann Intern Med. 2020;173(9):685–93.
22.
go back to reference Ashrafian H, Toma T, Rowland SP, et al. Bariatric surgery or non-surgical weight loss for obstructive sleep apnoea? A systematic review and comparison of meta-analyses. Obes Surg. 2015;25(7):1239–50.CrossRef Ashrafian H, Toma T, Rowland SP, et al. Bariatric surgery or non-surgical weight loss for obstructive sleep apnoea? A systematic review and comparison of meta-analyses. Obes Surg. 2015;25(7):1239–50.CrossRef
23.
go back to reference Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2018;138(17):e484–594.PubMed Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2018;138(17):e484–594.PubMed
24.
go back to reference American Diabetes Association. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes – 2020. Diabetes Care. 2020;43(Suppl 1):S14–31. American Diabetes Association. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes – 2020. Diabetes Care. 2020;43(Suppl 1):S14–31.
25.
go back to reference Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;139(25):e1082–e143.PubMed Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;139(25):e1082–e143.PubMed
26.
go back to reference Laratta CR, Ayas NT, Povitz M, et al. Diagnosis and treatment of obstructive sleep apnea in adults. CMAJ. 2017;189(48):E1481–E8.CrossRef Laratta CR, Ayas NT, Povitz M, et al. Diagnosis and treatment of obstructive sleep apnea in adults. CMAJ. 2017;189(48):E1481–E8.CrossRef
27.
go back to reference Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41(6):1313–21.CrossRef Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41(6):1313–21.CrossRef
28.
go back to reference Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2018;67(1):328–57.CrossRef Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2018;67(1):328–57.CrossRef
29.
go back to reference Global BMI Mortality Collaboration, Di Angelantonio E, Bhupathiraju SN, et al. Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. Lancet. 2016;388(10046):776–86.CrossRef Global BMI Mortality Collaboration, Di Angelantonio E, Bhupathiraju SN, et al. Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. Lancet. 2016;388(10046):776–86.CrossRef
30.
go back to reference Pories WJ, Dohm LG, Mansfield CJ. Beyond the BMI: the search for better guidelines for bariatric surgery. Obesity (Silver Spring). 2010;18(5):865–71.CrossRef Pories WJ, Dohm LG, Mansfield CJ. Beyond the BMI: the search for better guidelines for bariatric surgery. Obesity (Silver Spring). 2010;18(5):865–71.CrossRef
31.
go back to reference Casimiro Pérez JA, Fernández Quesada C, Del Val Groba Marco M, et al. Obesity Surgery Score (OSS) for prioritization in the bariatric surgery waiting list: a need of public health systems and a literature review. Obes Surg. 2018;28(4):1175–84.CrossRef Casimiro Pérez JA, Fernández Quesada C, Del Val Groba Marco M, et al. Obesity Surgery Score (OSS) for prioritization in the bariatric surgery waiting list: a need of public health systems and a literature review. Obes Surg. 2018;28(4):1175–84.CrossRef
32.
go back to reference Whitty JA, Ratcliffe J, Kendall E, et al. Prioritising patients for bariatric surgery: building public preferences from a discrete choice experiment into public policy. BMJ Open. 2015;5(10):e008919.CrossRef Whitty JA, Ratcliffe J, Kendall E, et al. Prioritising patients for bariatric surgery: building public preferences from a discrete choice experiment into public policy. BMJ Open. 2015;5(10):e008919.CrossRef
33.
go back to reference Rubino F, Cohen RV, Mingrone G, et al. Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery. Lancet Diabetes Endocrinol. 2020;8(7):640–8.CrossRef Rubino F, Cohen RV, Mingrone G, et al. Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery. Lancet Diabetes Endocrinol. 2020;8(7):640–8.CrossRef
34.
go back to reference Pirlet C, Biertho L, Poirier P, et al. Comparison of short and long term cardiovascular outcomes after bariatric surgery in patients with vs without coronary artery disease. Am J Cardiol. 2020;125(1):40–7.CrossRef Pirlet C, Biertho L, Poirier P, et al. Comparison of short and long term cardiovascular outcomes after bariatric surgery in patients with vs without coronary artery disease. Am J Cardiol. 2020;125(1):40–7.CrossRef
35.
go back to reference Delling L, Karason K, Olbers T, et al. Feasibility of bariatric surgery as a strategy for secondary prevention in cardiovascular disease: a report from the Swedish obese subjects trial. J Obes. 2010;2010:1–6.CrossRef Delling L, Karason K, Olbers T, et al. Feasibility of bariatric surgery as a strategy for secondary prevention in cardiovascular disease: a report from the Swedish obese subjects trial. J Obes. 2010;2010:1–6.CrossRef
36.
go back to reference Gill RS, Majumdar SR, Wang X, et al. Prioritization and willingness to pay for bariatric surgery: the patient perspective. Can J Surg. 2014;57(1):33–9.CrossRef Gill RS, Majumdar SR, Wang X, et al. Prioritization and willingness to pay for bariatric surgery: the patient perspective. Can J Surg. 2014;57(1):33–9.CrossRef
37.
go back to reference Sjöström L, Peltonen M, Jacobson P, et al. Bariatric surgery and long-term cardiovascular events. JAMA. 2012;307(1):56–65.CrossRef Sjöström L, Peltonen M, Jacobson P, et al. Bariatric surgery and long-term cardiovascular events. JAMA. 2012;307(1):56–65.CrossRef
38.
go back to reference Sjöström L. Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. J Intern Med. 2013;273(3):219–34.CrossRef Sjöström L. Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. J Intern Med. 2013;273(3):219–34.CrossRef
39.
go back to reference Lee Y, Doumouras AG, Yu J, et al. Complete resolution of nonalcoholic fatty liver disease after bariatric surgery: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2019;17(6):1040–60.e11.CrossRef Lee Y, Doumouras AG, Yu J, et al. Complete resolution of nonalcoholic fatty liver disease after bariatric surgery: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2019;17(6):1040–60.e11.CrossRef
40.
go back to reference Horvath CM, Jossen J, Kröll D, et al. Prevalence and prediction of obstructive sleep apnea prior to bariatric surgery-gender-specific performance of four sleep questionnaires. Obes Surg. 2018;28(9):2720–6.CrossRef Horvath CM, Jossen J, Kröll D, et al. Prevalence and prediction of obstructive sleep apnea prior to bariatric surgery-gender-specific performance of four sleep questionnaires. Obes Surg. 2018;28(9):2720–6.CrossRef
41.
go back to reference Kositanurit W, Muntham D, Udomsawaengsup S, et al. Prevalence and associated factors of obstructive sleep apnea in morbidly obese patients undergoing bariatric surgery. Sleep Breath. 2018;22(1):251–6.CrossRef Kositanurit W, Muntham D, Udomsawaengsup S, et al. Prevalence and associated factors of obstructive sleep apnea in morbidly obese patients undergoing bariatric surgery. Sleep Breath. 2018;22(1):251–6.CrossRef
42.
go back to reference O'Reilly E, Doherty L, O'Boyle C. How relevant is pre-operative obstructive sleep apnoea in the asymptomatic bariatric surgery patient? Obes Surg. 2020;30(3):969–74.CrossRef O'Reilly E, Doherty L, O'Boyle C. How relevant is pre-operative obstructive sleep apnoea in the asymptomatic bariatric surgery patient? Obes Surg. 2020;30(3):969–74.CrossRef
43.
go back to reference Duarte RLM, Fonseca LBM, Magalhães-da-Silveira FJ, et al. Validation of the STOP-Bang questionnaire as a means of screening for obstructive sleep apnea in adults in Brazil. J Bras Pneumol. 2017;43(6):456–63.CrossRef Duarte RLM, Fonseca LBM, Magalhães-da-Silveira FJ, et al. Validation of the STOP-Bang questionnaire as a means of screening for obstructive sleep apnea in adults in Brazil. J Bras Pneumol. 2017;43(6):456–63.CrossRef
Metadata
Title
Development and Validation of a Predictive Model of Success in Bariatric Surgery
Authors
Carina A. Blume
Priscila G. Brust-Renck
Miriam K. Rocha
Gabriel Leivas
Jeruza L. Neyeloff
Michel J. Anzanello
Flavio S. Fogliatto
Luciana R. Bahia
Gabriela H. Telo
Beatriz D. Schaan
Publication date
01-03-2021
Publisher
Springer US
Published in
Obesity Surgery / Issue 3/2021
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-020-05103-0

Other articles of this Issue 3/2021

Obesity Surgery 3/2021 Go to the issue