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BMC Psychiatry
Published in: BMC Psychiatry 1/2016

Open Access 01-12-2016 | Research article

Psychotherapy effectiveness for major depression: a randomized trial in a Finnish community

Authors: Hannu P. Saloheimo, John Markowitz, Tuija H. Saloheimo, Jarmo J. Laitinen, Jari Sundell, Matti O. Huttunen, Timo A. Aro, Tuitu N. Mikkonen, Heikki O. Katila

Published in: BMC Psychiatry | Issue 1/2016

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Abstract

Background

The purpose of this study is to assess the relative effectiveness of Interpersonal Psychotherapy (IPT), Psychoeducative Group Therapy (PeGT), and treatment as usual (TAU) for patients with Major Depressive Disorder (MDD) in municipal psychiatric secondary care in one Finnish region.

Methods

All adult patients (N = 1515) with MDD symptoms referred to secondary care in 2004-2006 were screened. Eligible, consenting patients were assigned randomly to 10-week IPT (N = 46), PeGT (N = 42), or TAU (N = 46) treatment arms. Antidepressant pharmacotherapy among study participants was evaluated. The Hamilton Depression Rating scale (HAM-D) was the primary outcome measure. Assessment occurred at 1, 5, 3, 6, and 12 months. Actual amount of therapists’ labor was also evaluated. All statistical analyses were performed with R software.

Results

All three treatment cells showed marked improvement at 12-month follow-up. At 3 months, 42 % in IPT, 61 % in PeGT, and 42 % in TAU showed a mean ≥50 % in HAM-D improvement; after 12 months, these values were 61 %, 76 %, and 68 %.
Concomitant medication and limited sample size minimized between-treatment differences. Statistically significant differences emerged only between PeGT and TAU favoring PeGT. Secondary outcome measures (CGI-s and SOFAS) showed parallel results.

Conclusion

All three treatments notably benefited highly comorbid MDD patients in a public sector secondary care unit.

Trial registration

ClinicalTrials.gov NCT02314767 (09.12.2014).
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Metadata
Title
Psychotherapy effectiveness for major depression: a randomized trial in a Finnish community
Authors
Hannu P. Saloheimo
John Markowitz
Tuija H. Saloheimo
Jarmo J. Laitinen
Jari Sundell
Matti O. Huttunen
Timo A. Aro
Tuitu N. Mikkonen
Heikki O. Katila
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2016
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-016-0838-1

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