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Published in: Current Neurology and Neuroscience Reports 9/2017

01-09-2017 | Epilepsy (CW Bazil, Section Editor)

Psychogenic Non-Epileptic Seizures

Authors: David K. Chen, Esha Sharma, W. Curt LaFrance Jr

Published in: Current Neurology and Neuroscience Reports | Issue 9/2017

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Abstract

Purpose of Review

In this review, we elucidate the evaluation process involved in the diagnosis of psychogenic non-epileptic seizures (PNES). Minimum clinical criteria required to attain this diagnosis via a staged approach are delineated. The psychological underpinnings and management of PNES from the neurologists’ perspective are also explored.

Recent Findings

Helpful clues can be deduced from history-taking, seizure semiology, ictal/peri-ictal physical exam, and ictal/inter-ictal EEG data. No single clinical data point is definitively diagnostic of PNES. Instead, the level of certainty for PNES diagnosis is contingent upon concordance of the composite clinical evidence available. Robust neurologist-patient alliance not only facilitates the evaluation process but can influence therapeutic impact.

Summary

While diagnosis of PNES can be challenging, this diagnosis can be reliably made upon establishing concordance of the historical, physical exam, and video-EEG findings. Evidence-based treatments are available for patients with PNES. Continued efforts remain necessary to enhance timely diagnosis and interdisciplinary management for patients with PNES.
Literature
1.
go back to reference Benbadis SR. How many patients with pseudoseizures receive antiepileptic drugs prior to diagnosis? Eur Neurol. 1999;41:114–5.CrossRefPubMed Benbadis SR. How many patients with pseudoseizures receive antiepileptic drugs prior to diagnosis? Eur Neurol. 1999;41:114–5.CrossRefPubMed
2.
go back to reference Smith D, Defalla BA, Chadwick DW. The misdiagnosis of epilepsy and the management of refractory epilepsy. QJM. 1999;92:15–23.CrossRefPubMed Smith D, Defalla BA, Chadwick DW. The misdiagnosis of epilepsy and the management of refractory epilepsy. QJM. 1999;92:15–23.CrossRefPubMed
3.
go back to reference Reuber M, Fernández G, Bauer J, Helmstaedter C, Elger CE. Diagnostic delay in psychogenic seizures. Neurology. 2002;58:493–5.CrossRefPubMed Reuber M, Fernández G, Bauer J, Helmstaedter C, Elger CE. Diagnostic delay in psychogenic seizures. Neurology. 2002;58:493–5.CrossRefPubMed
4.
go back to reference Magee JA, Burke T, Deluaty N, Pender N, Fortune GM. The economic costs of nonepileptic attack disorder in Ireland. Epilepsy Behav. 2014;33:45–8.CrossRefPubMed Magee JA, Burke T, Deluaty N, Pender N, Fortune GM. The economic costs of nonepileptic attack disorder in Ireland. Epilepsy Behav. 2014;33:45–8.CrossRefPubMed
5.
go back to reference Reuber M, Baker GA, Gill R, Smith DF, Chadwick DW. Failure to recognize psychogenic nonepileptic seizures may cause death. Neurology. 2004;62:834–5.CrossRefPubMed Reuber M, Baker GA, Gill R, Smith DF, Chadwick DW. Failure to recognize psychogenic nonepileptic seizures may cause death. Neurology. 2004;62:834–5.CrossRefPubMed
6.
go back to reference Selwa LM, Geyer J, Nikakhtar N, Brown MB, Schuh LA, Drury I. Nonepileptic seizure outcome varies by type of spell and duration of illness. Epilepsia. 2000;41:1330–4.CrossRefPubMed Selwa LM, Geyer J, Nikakhtar N, Brown MB, Schuh LA, Drury I. Nonepileptic seizure outcome varies by type of spell and duration of illness. Epilepsia. 2000;41:1330–4.CrossRefPubMed
7.
go back to reference Reuber M. Psychogenic nonepilepsy seizures: answers and questions. Epielpsy Behav. 2008;12:622–35.CrossRef Reuber M. Psychogenic nonepilepsy seizures: answers and questions. Epielpsy Behav. 2008;12:622–35.CrossRef
8.
go back to reference Bhatia MS, Sapra S. Pseudoseizures in children: a profile of 50 cases. Clin Pediatr (Phila). 2005;44:617–21.CrossRef Bhatia MS, Sapra S. Pseudoseizures in children: a profile of 50 cases. Clin Pediatr (Phila). 2005;44:617–21.CrossRef
9.
go back to reference Bowman ES, Markand ON. Psychodynamics and psychiatric diagnoses of pseudoseizure subjects. Am J Psychiatry. 1996;153:57–63.CrossRefPubMed Bowman ES, Markand ON. Psychodynamics and psychiatric diagnoses of pseudoseizure subjects. Am J Psychiatry. 1996;153:57–63.CrossRefPubMed
10.
go back to reference Myers L, Perrine K, Lancman M, Fleming M, Lancman M. Psychological trauma in patients with psychogenic nonepileptic seizures: trauma characteristics and those who develop PTSD. Epilepsy Behav. 2013;28:121–6.CrossRefPubMed Myers L, Perrine K, Lancman M, Fleming M, Lancman M. Psychological trauma in patients with psychogenic nonepileptic seizures: trauma characteristics and those who develop PTSD. Epilepsy Behav. 2013;28:121–6.CrossRefPubMed
11.
go back to reference Dixit R, Popescu A, Bagic A, Ghearing G, Hendrickson R. Medical comorbidities in patients with psychogenic nonepileptic spells (PNES) referred for video-EEG monitoring. Epilepsy Behav. 2013;28:137–40.CrossRefPubMed Dixit R, Popescu A, Bagic A, Ghearing G, Hendrickson R. Medical comorbidities in patients with psychogenic nonepileptic spells (PNES) referred for video-EEG monitoring. Epilepsy Behav. 2013;28:137–40.CrossRefPubMed
12.
go back to reference Westbrook LE, Devinski O, Geocadin R. Nonepileptic seizures after head injury. Epilepsia. 1998;39:978–82.CrossRefPubMed Westbrook LE, Devinski O, Geocadin R. Nonepileptic seizures after head injury. Epilepsia. 1998;39:978–82.CrossRefPubMed
13.
go back to reference Reuber M, Kral T, Kurthen M. New-onset psychogenic seizures after intracranial neurosurgery. Acta Neurochir. 2002;144:901–7.CrossRefPubMed Reuber M, Kral T, Kurthen M. New-onset psychogenic seizures after intracranial neurosurgery. Acta Neurochir. 2002;144:901–7.CrossRefPubMed
14.
go back to reference Duncan R, Oto M. Predictors of antecedent factors on psychogenic nonepileptic attacks: multivariate analyses. Neurology. 2008;71:1000–5.CrossRefPubMed Duncan R, Oto M. Predictors of antecedent factors on psychogenic nonepileptic attacks: multivariate analyses. Neurology. 2008;71:1000–5.CrossRefPubMed
15.
go back to reference Blum AS, LaFrance WC Jr. Overview of psychological nonepileptic seizures. In: Ettinger AD, Kanner AM, editors. Psychiatric issues in epilepsy: a practical guide to diagnosis and treatment. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2007. p.420–431. Blum AS, LaFrance WC Jr. Overview of psychological nonepileptic seizures. In: Ettinger AD, Kanner AM, editors. Psychiatric issues in epilepsy: a practical guide to diagnosis and treatment. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2007. p.420–431.
16.
go back to reference Reuber M, Pukrop R, Mitchell AJ, Bauer J, Elger CE. Clinical significance of recurrent psychogenic nonepileptic seizure status. J Neurol. 2003;250:1355–62.CrossRefPubMed Reuber M, Pukrop R, Mitchell AJ, Bauer J, Elger CE. Clinical significance of recurrent psychogenic nonepileptic seizure status. J Neurol. 2003;250:1355–62.CrossRefPubMed
17.
go back to reference Frucht MM, Quigg M, Schwaner C, Fountain NB. Distribution of seizure precipitants among epilepsy syndromes. Epilepsia. 2000;41:1534–9.CrossRefPubMed Frucht MM, Quigg M, Schwaner C, Fountain NB. Distribution of seizure precipitants among epilepsy syndromes. Epilepsia. 2000;41:1534–9.CrossRefPubMed
18.
go back to reference Reuber M, Monzoni C, Sharrack B, Plug L. Using conversation analysis to distinguish between epilepsy and non-epileptic seizures: a prospective blinded multirater study. Epilepsy Behav. 2009;16:139–44.CrossRefPubMed Reuber M, Monzoni C, Sharrack B, Plug L. Using conversation analysis to distinguish between epilepsy and non-epileptic seizures: a prospective blinded multirater study. Epilepsy Behav. 2009;16:139–44.CrossRefPubMed
19.
go back to reference Robson C, Drew P, Walker T, Rebuer M. Catastrophising and normalising in patient’s accounts of their seizure experiences. Seizure. 2012;21:795–801.CrossRefPubMed Robson C, Drew P, Walker T, Rebuer M. Catastrophising and normalising in patient’s accounts of their seizure experiences. Seizure. 2012;21:795–801.CrossRefPubMed
20.
go back to reference American Psychiatric Association. Diagnostic and statistical manual of mental disorders, fourth edition (DSM-IV). Washington DC: American Psychiatric Association; 2000.CrossRef American Psychiatric Association. Diagnostic and statistical manual of mental disorders, fourth edition (DSM-IV). Washington DC: American Psychiatric Association; 2000.CrossRef
21.
go back to reference American Psychiatric Association. Diagnostic and statistical manual of mental disorders, fifth edition (DSM-5). Washington, DC: American Psychiatric Association; 2013.CrossRef American Psychiatric Association. Diagnostic and statistical manual of mental disorders, fifth edition (DSM-5). Washington, DC: American Psychiatric Association; 2013.CrossRef
22.
go back to reference Chen DK, Graber KD, Anderson CT, Fisher RS. Sensitivity and specificty of video alone versus electroencephalography alone for the diagnosis of partial seizures. Epilepsy Behav. 2008;13:115–8.CrossRefPubMed Chen DK, Graber KD, Anderson CT, Fisher RS. Sensitivity and specificty of video alone versus electroencephalography alone for the diagnosis of partial seizures. Epilepsy Behav. 2008;13:115–8.CrossRefPubMed
23.
go back to reference Benbadis SR, Lancman ME, King LM, Swanson SJ. Preictal pseudosleep: a new finding in psychogenic seizures. Neurology. 1996;47:63–7.CrossRefPubMed Benbadis SR, Lancman ME, King LM, Swanson SJ. Preictal pseudosleep: a new finding in psychogenic seizures. Neurology. 1996;47:63–7.CrossRefPubMed
24.
go back to reference Vinton A, Carino J, Vogrin S, Macgregor L, Kilpatrick C, Matkovic Z, et al. “Convulsive” nonepileptic seizures have a characteristic pattern of rhythmic artifacts distinguishing them from convulsive epileptic seizures. Epilepsia. 2004;45:1344–50.CrossRefPubMed Vinton A, Carino J, Vogrin S, Macgregor L, Kilpatrick C, Matkovic Z, et al. “Convulsive” nonepileptic seizures have a characteristic pattern of rhythmic artifacts distinguishing them from convulsive epileptic seizures. Epilepsia. 2004;45:1344–50.CrossRefPubMed
25.
go back to reference Rosemergy I, Frith R, Herath S, Walker E. Use of postictal respiratory pattern to discriminate between convulsive psychogenic nonepileptic seizures and generalized tonic-clonic seizures. Epilepsy Behav. 2013;27:81–4.CrossRefPubMed Rosemergy I, Frith R, Herath S, Walker E. Use of postictal respiratory pattern to discriminate between convulsive psychogenic nonepileptic seizures and generalized tonic-clonic seizures. Epilepsy Behav. 2013;27:81–4.CrossRefPubMed
26.
go back to reference Syed TU, LaFance WC Jr, Kahriman ES. Can semiology predict psychogenic nonepileptic seizures? A prospective study. Ann Neurol. 2011;69:997–1004.CrossRefPubMed Syed TU, LaFance WC Jr, Kahriman ES. Can semiology predict psychogenic nonepileptic seizures? A prospective study. Ann Neurol. 2011;69:997–1004.CrossRefPubMed
27.
go back to reference Benbadis SR, Chickkova R. Psychogenic pseudosyncope: an underestimated and provable diagnosis. Epilepsy Behav. 2006;9:106–10.CrossRefPubMed Benbadis SR, Chickkova R. Psychogenic pseudosyncope: an underestimated and provable diagnosis. Epilepsy Behav. 2006;9:106–10.CrossRefPubMed
28.
go back to reference Devinsky O, Kelley K, Porter RJ, Theodore WH. Clinical and electroencephalographic features of simple partial seizures. Neurology. 1988;38:1347–52.CrossRefPubMed Devinsky O, Kelley K, Porter RJ, Theodore WH. Clinical and electroencephalographic features of simple partial seizures. Neurology. 1988;38:1347–52.CrossRefPubMed
29.
go back to reference Frontera AT Jr. Classification of seizures and epilepsy syndromes. In: Husain AM, Tran TT, editors. Department of Veteran Affairs epilepsy manual. San Francisco: Epilepsy Centers of Excellence, Department of Veterans Affairs; 2014. Frontera AT Jr. Classification of seizures and epilepsy syndromes. In: Husain AM, Tran TT, editors. Department of Veteran Affairs epilepsy manual. San Francisco: Epilepsy Centers of Excellence, Department of Veterans Affairs; 2014.
30.
go back to reference Benbadis SR, Agrawal V, Tatum WO 4th. How many patients with psychogenic nonepileptic seizures also have epilepsy? Neurology. 2001;57:915–7.CrossRefPubMed Benbadis SR, Agrawal V, Tatum WO 4th. How many patients with psychogenic nonepileptic seizures also have epilepsy? Neurology. 2001;57:915–7.CrossRefPubMed
31.
go back to reference Duncan R, Oto M. Psychogenic nonepileptic seizures in patients with learning disability: comparison with patients with no learning disability. Epilepsy Behav. 2008;12:183–6.CrossRefPubMed Duncan R, Oto M. Psychogenic nonepileptic seizures in patients with learning disability: comparison with patients with no learning disability. Epilepsy Behav. 2008;12:183–6.CrossRefPubMed
32.
go back to reference Mari F, Di Bonaventura C, Vanacore N, Fattouch J, Vaudano AE, Egeo G, et al. Video-EEG study of psychogenic nonepileptic seizures: differential characteristics in patients with and without epilepsy. Epilepsia. 2006;47(Suppl 5):64–7.CrossRefPubMed Mari F, Di Bonaventura C, Vanacore N, Fattouch J, Vaudano AE, Egeo G, et al. Video-EEG study of psychogenic nonepileptic seizures: differential characteristics in patients with and without epilepsy. Epilepsia. 2006;47(Suppl 5):64–7.CrossRefPubMed
33.
go back to reference Reuber M, Qurishi A, Bauer J, Helmstaedter C, Fernandez G, Widman G. Are there physical risk factors for psychogenic non-epileptic seizures in patients with epilepsy? Seizure. 2003;12:561–7.CrossRefPubMed Reuber M, Qurishi A, Bauer J, Helmstaedter C, Fernandez G, Widman G. Are there physical risk factors for psychogenic non-epileptic seizures in patients with epilepsy? Seizure. 2003;12:561–7.CrossRefPubMed
34.
go back to reference Parra J, Kanner AM, Iriarte J, Gil-Nagel A. When should induction protocols be used in the diagnostic evaluation of patients with paroxysmal events? Epilepsia. 1998;39:863–7.CrossRefPubMed Parra J, Kanner AM, Iriarte J, Gil-Nagel A. When should induction protocols be used in the diagnostic evaluation of patients with paroxysmal events? Epilepsia. 1998;39:863–7.CrossRefPubMed
35.
go back to reference Benbadis SR, Siegrist K, Tatum WO, Heriaud L, Anthony K. Short-term outpatient EEG video with induction in the diagnosis of psychogenic seizures. Neurology. 2004;63:1728–30.CrossRefPubMed Benbadis SR, Siegrist K, Tatum WO, Heriaud L, Anthony K. Short-term outpatient EEG video with induction in the diagnosis of psychogenic seizures. Neurology. 2004;63:1728–30.CrossRefPubMed
36.
go back to reference Walczak TS, Williams DT, Berten W. Utility and reliability of placebo infusion in the evaluation of patients with seizures. Neurology. 1994;44:394–9.CrossRefPubMed Walczak TS, Williams DT, Berten W. Utility and reliability of placebo infusion in the evaluation of patients with seizures. Neurology. 1994;44:394–9.CrossRefPubMed
38.
go back to reference Chen DK, Izadyar S, Collins RL, Benge JF, Lemaire AW, Hrachovy RA. Induction of psychogenic nonepileptic seizures: success rate influenced by prior induction exposure, ictal semiology, and psychological profile. Epilepsia. 2011;52:1063–70.CrossRefPubMed Chen DK, Izadyar S, Collins RL, Benge JF, Lemaire AW, Hrachovy RA. Induction of psychogenic nonepileptic seizures: success rate influenced by prior induction exposure, ictal semiology, and psychological profile. Epilepsia. 2011;52:1063–70.CrossRefPubMed
39.
go back to reference Schachter SC, Brown F, Rowan AJ. Provocative testing for nonepileptic seizures: attitudes and practices in the United States among American Epilepsy Society members. J Epilepsy. 1996;9:249–52.CrossRef Schachter SC, Brown F, Rowan AJ. Provocative testing for nonepileptic seizures: attitudes and practices in the United States among American Epilepsy Society members. J Epilepsy. 1996;9:249–52.CrossRef
40.
go back to reference Stagno SJ, Smith ML. Use of induction procedures in diagnosing psychogenic seizures. J Epilepsy. 1996;9:153–8.CrossRef Stagno SJ, Smith ML. Use of induction procedures in diagnosing psychogenic seizures. J Epilepsy. 1996;9:153–8.CrossRef
41.
go back to reference Benbadis SR, Johnson K, Anthony K, Caines G, Hess G, Jackson C, et al. Induction of psychogenic nonepileptic seizures without placebo. Neurology. 2000;55:1904–5.CrossRefPubMed Benbadis SR, Johnson K, Anthony K, Caines G, Hess G, Jackson C, et al. Induction of psychogenic nonepileptic seizures without placebo. Neurology. 2000;55:1904–5.CrossRefPubMed
42.
go back to reference Tatum WO, Hirsch L, Duckrow R, Chen DK, Gelfand M, LaFrance WC Jr. Outpatient smartphone videos in epilepsy (OSmartViE): initial results. In: Abstract 3.159, 70th American Epilepsy Society Annual Meeting; 2016. Tatum WO, Hirsch L, Duckrow R, Chen DK, Gelfand M, LaFrance WC Jr. Outpatient smartphone videos in epilepsy (OSmartViE): initial results. In: Abstract 3.159, 70th American Epilepsy Society Annual Meeting; 2016.
43.
go back to reference LaFrance WC Jr, Baker GA, Duncan R, Goldstein LH, Reuber M. Minimal requirements for the diagnosis of psychogenic nonepileptic seizures: a staged approach. Epilepsia. 2013;54:2005–18.CrossRefPubMed LaFrance WC Jr, Baker GA, Duncan R, Goldstein LH, Reuber M. Minimal requirements for the diagnosis of psychogenic nonepileptic seizures: a staged approach. Epilepsia. 2013;54:2005–18.CrossRefPubMed
44.
go back to reference Kalogjera-Sackellares D. Psychodynamics and psychotherapy of pseudoseizures. Wales: Crown House Publishing; 2004. Kalogjera-Sackellares D. Psychodynamics and psychotherapy of pseudoseizures. Wales: Crown House Publishing; 2004.
45.
go back to reference Betts T, Boden S. Diagnosis, management and prognosis of a group of 128 correlates of intractable pseudoseizures. Part II. Previous childhood sexual abuse in the aetiology of these disorders. Seizure. 1992;1:27–32.CrossRefPubMed Betts T, Boden S. Diagnosis, management and prognosis of a group of 128 correlates of intractable pseudoseizures. Part II. Previous childhood sexual abuse in the aetiology of these disorders. Seizure. 1992;1:27–32.CrossRefPubMed
46.
go back to reference Stone J, Binzer M, Sharpe M. Illness beliefs and locus of control: a comparison of patients with pseudoseizures and epilepsy. J Psychosom Res. 2004;57:541–7.CrossRefPubMed Stone J, Binzer M, Sharpe M. Illness beliefs and locus of control: a comparison of patients with pseudoseizures and epilepsy. J Psychosom Res. 2004;57:541–7.CrossRefPubMed
47.
go back to reference Benbadis SR. Differential diagnosis of epilepsy. Continuum (Minneap Minn). 2007;13:48–70. Benbadis SR. Differential diagnosis of epilepsy. Continuum (Minneap Minn). 2007;13:48–70.
48.
go back to reference Caplan R, Plioplys S. Psychiatric features and management of children with psychogenic nonepileptic seizures. In: Schachter SC, WC Jr LF, editors. Gates and Rowan’s nonepileptic seizures. 3rd ed. Cambridge: Cambridge University Press; 2010. Caplan R, Plioplys S. Psychiatric features and management of children with psychogenic nonepileptic seizures. In: Schachter SC, WC Jr LF, editors. Gates and Rowan’s nonepileptic seizures. 3rd ed. Cambridge: Cambridge University Press; 2010.
49.
go back to reference Helms A, Shulman L. Movement disorders that imitate epilepsy. In: Kaplan PW, Fsher RS, editors. Imitators of epilepsy. 2nd ed. New York: Demos Medical Publishing; 2005. Helms A, Shulman L. Movement disorders that imitate epilepsy. In: Kaplan PW, Fsher RS, editors. Imitators of epilepsy. 2nd ed. New York: Demos Medical Publishing; 2005.
50.
go back to reference Hempel A. Cognitive features and predisposing factors in children with psychogenic seizures. In: Gates JR, Rowan AJ, editors. Non-epileptic seizures. Boston: Butterworth-Heinemann; 2000. Hempel A. Cognitive features and predisposing factors in children with psychogenic seizures. In: Gates JR, Rowan AJ, editors. Non-epileptic seizures. Boston: Butterworth-Heinemann; 2000.
51.
go back to reference Wyllie E, Friedman D, Lüders H, Morris H, Rothner D, Turnbull J. Outcomes of psychogenic seizures in children and adolescents compared to adults. Neurology. 1991;41:742–4.CrossRefPubMed Wyllie E, Friedman D, Lüders H, Morris H, Rothner D, Turnbull J. Outcomes of psychogenic seizures in children and adolescents compared to adults. Neurology. 1991;41:742–4.CrossRefPubMed
52.
go back to reference LaFrance WC Jr, Reuber M, Goldstein LH. Management of psychogenic nonepileptic seizures. Epilepsia. 2013;54(Suppl 1):53–67.CrossRefPubMed LaFrance WC Jr, Reuber M, Goldstein LH. Management of psychogenic nonepileptic seizures. Epilepsia. 2013;54(Suppl 1):53–67.CrossRefPubMed
53.
go back to reference Ettinger AB, Devinsky O, Weisbrot DM, Goyal A, Shashikumar S. Headaches and other pain symptoms among patients with psychogenic non-epileptic seizures. Seizure. 1999;8:424–6.CrossRefPubMed Ettinger AB, Devinsky O, Weisbrot DM, Goyal A, Shashikumar S. Headaches and other pain symptoms among patients with psychogenic non-epileptic seizures. Seizure. 1999;8:424–6.CrossRefPubMed
54.
go back to reference Mayor R, Brown RJ, Cock H, House A, Howlett S, Singhal S, et al. Short-term outcome of psychogenic non-epileptic seizures after communication of the diagnosis. Epilepsy Behav. 2012;25:676–81.CrossRefPubMed Mayor R, Brown RJ, Cock H, House A, Howlett S, Singhal S, et al. Short-term outcome of psychogenic non-epileptic seizures after communication of the diagnosis. Epilepsy Behav. 2012;25:676–81.CrossRefPubMed
55.
go back to reference Goldstein LH, Chalder T, Chigwedere C, Khondoker MR, Moriarty J, Toone BK, et al. Cognitive-behavioral therapy for psychogenic nonepileptic seizures: a pilot RCT. Neurology. 2010;74:1986–94.CrossRefPubMedPubMedCentral Goldstein LH, Chalder T, Chigwedere C, Khondoker MR, Moriarty J, Toone BK, et al. Cognitive-behavioral therapy for psychogenic nonepileptic seizures: a pilot RCT. Neurology. 2010;74:1986–94.CrossRefPubMedPubMedCentral
56.
go back to reference •• LaFrance WC Jr, Baird GL, Barry JJ, Blum AS, Frank Webb A, Keitner GI, et al. Multicenter pilot treatment trial for psychogenic nonepileptic seizures: a randomized clinical trial. JAMA Psychiatry. 2014;71:997–1005. Patients in the CBT intervention arm showed significant seizure reduction compared to before intervention. Secondary outcomes such as depression, anxiety, quality of of life, and global functioning measures all showed improvement at the end of treatment compared to before treatment CrossRefPubMed •• LaFrance WC Jr, Baird GL, Barry JJ, Blum AS, Frank Webb A, Keitner GI, et al. Multicenter pilot treatment trial for psychogenic nonepileptic seizures: a randomized clinical trial. JAMA Psychiatry. 2014;71:997–1005. Patients in the CBT intervention arm showed significant seizure reduction compared to before intervention. Secondary outcomes such as depression, anxiety, quality of of life, and global functioning measures all showed improvement at the end of treatment compared to before treatment CrossRefPubMed
57.
go back to reference •• Reiter J, Andrews D, Reiter C, LaFrance WC Jr. Taking control of your seizures: workbook. New York: Oxford University Press; 2015. This workbook details 12 weekly manualized sessions based on a multimodality, CBT-informed psychotherapy model (CBT-ip) initially developed to enhance self-control of epileptic seizures. This model conceptualizes PNES as the somatic manifestations of maladaptive core beliefs that have been derived acute, recurring, or chronic adverse life experiences/traumas CrossRef •• Reiter J, Andrews D, Reiter C, LaFrance WC Jr. Taking control of your seizures: workbook. New York: Oxford University Press; 2015. This workbook details 12 weekly manualized sessions based on a multimodality, CBT-informed psychotherapy model (CBT-ip) initially developed to enhance self-control of epileptic seizures. This model conceptualizes PNES as the somatic manifestations of maladaptive core beliefs that have been derived acute, recurring, or chronic adverse life experiences/traumas CrossRef
59.
go back to reference LaFrance WC Jr, Ranieri R, Bamps Y, Stoll S, Sahoo SS, Welter E, et al. Comparison of common data elements from the Managing Epilepsy Well (MEW) network integrated database and a well-characterized sample with nonepileptic seizures. Epilepsy Behav. 2015;45:136–41.CrossRefPubMed LaFrance WC Jr, Ranieri R, Bamps Y, Stoll S, Sahoo SS, Welter E, et al. Comparison of common data elements from the Managing Epilepsy Well (MEW) network integrated database and a well-characterized sample with nonepileptic seizures. Epilepsy Behav. 2015;45:136–41.CrossRefPubMed
60.
go back to reference Asmussen SB, Kirlin KA, Gale SD, Chung SS. Differences in self-reported depressive symptoms between patients with epileptic and psychogenic nonepileptic seizures. Seizure. 2009;18:564–6.CrossRefPubMed Asmussen SB, Kirlin KA, Gale SD, Chung SS. Differences in self-reported depressive symptoms between patients with epileptic and psychogenic nonepileptic seizures. Seizure. 2009;18:564–6.CrossRefPubMed
61.
go back to reference Grimaldi I, Dubuc M, Kahane P, Bougerol T, Vercueil L. Anxiety and depression in psychogenic movement disorder and non-epileptic seizures: a prospective comparative study. Rev Neurol (Paris). 2010;166:515–22.CrossRef Grimaldi I, Dubuc M, Kahane P, Bougerol T, Vercueil L. Anxiety and depression in psychogenic movement disorder and non-epileptic seizures: a prospective comparative study. Rev Neurol (Paris). 2010;166:515–22.CrossRef
62.
go back to reference Mazza M, Della Marca G, Martini A, Scoppetta M, Vollono C, Valenti MA, et al. Non-epileptic seizures (NES) are predicted by depressive and dissociative symptoms. Epilepsy Res. 2009;84:91–6.CrossRefPubMed Mazza M, Della Marca G, Martini A, Scoppetta M, Vollono C, Valenti MA, et al. Non-epileptic seizures (NES) are predicted by depressive and dissociative symptoms. Epilepsy Res. 2009;84:91–6.CrossRefPubMed
63.
go back to reference • Plioplys S, Doss J, Siddarth P, Bursch B, Falcone T, Forgey M, et al. A multisite controlled study of risk factors in pediatric psychogenic nonepileptic seizures. Epilepsia. 2014;55:1739–47. To date, there are limited data available pertaining to psychiatric manifestations and risk factors associated with PNES in children. This timely study showed that comparing to siblings, children with PNES experienced significantly more lifetime comorbidities, including medical, neurologicas, and psychiatric problems. Moreover, they also utilized more medications and intensive medical services, had higher anxiety sensitivity, practiced solitary emotional coping, and experienced more lifetime adversities CrossRefPubMed • Plioplys S, Doss J, Siddarth P, Bursch B, Falcone T, Forgey M, et al. A multisite controlled study of risk factors in pediatric psychogenic nonepileptic seizures. Epilepsia. 2014;55:1739–47. To date, there are limited data available pertaining to psychiatric manifestations and risk factors associated with PNES in children. This timely study showed that comparing to siblings, children with PNES experienced significantly more lifetime comorbidities, including medical, neurologicas, and psychiatric problems. Moreover, they also utilized more medications and intensive medical services, had higher anxiety sensitivity, practiced solitary emotional coping, and experienced more lifetime adversities CrossRefPubMed
64.
go back to reference Plioplys S, Doss J, Siddarth P, Bursch B, Falcone T, Forgey M, et al. Risk factors for comorbid psychopathology in youth with psychogenic nonepileptic seizures. Seizure. 2016;38:32–7.CrossRefPubMed Plioplys S, Doss J, Siddarth P, Bursch B, Falcone T, Forgey M, et al. Risk factors for comorbid psychopathology in youth with psychogenic nonepileptic seizures. Seizure. 2016;38:32–7.CrossRefPubMed
65.
go back to reference Arnold LM, Privitera MD. Psychopathology and trauma in epileptic and psychogenic seizure patients. Psychosomatics. 1996;37:438–43.CrossRefPubMed Arnold LM, Privitera MD. Psychopathology and trauma in epileptic and psychogenic seizure patients. Psychosomatics. 1996;37:438–43.CrossRefPubMed
66.
go back to reference Harden CL, Jovine L, Burgut FT, Carey BT, Nikolov BG, Ferrando SJ. A comparison of personality disorder characteristics of patients with nonepileptic psychogenic pseudoseizures with those of patients with epilepsy. Epilepsy Behav. 2009;14:481–3.CrossRefPubMed Harden CL, Jovine L, Burgut FT, Carey BT, Nikolov BG, Ferrando SJ. A comparison of personality disorder characteristics of patients with nonepileptic psychogenic pseudoseizures with those of patients with epilepsy. Epilepsy Behav. 2009;14:481–3.CrossRefPubMed
67.
go back to reference Tremont G, Smith MM, Bauer L, Alosco ML, Davis JD, Blum AS, et al. Comparison of personality characteristics on the Bear-Fedio inventory between patients with epilepsy and those with non-epileptic seizures. J Neuropsychiatry Clin Neurosci. 2012;24:47–52.CrossRefPubMed Tremont G, Smith MM, Bauer L, Alosco ML, Davis JD, Blum AS, et al. Comparison of personality characteristics on the Bear-Fedio inventory between patients with epilepsy and those with non-epileptic seizures. J Neuropsychiatry Clin Neurosci. 2012;24:47–52.CrossRefPubMed
68.
go back to reference Baslet G, Roiko A, Prensky E. Heterogeneity in psychogenic nonepileptic seizures: understanding the role of psychiatric and neurological factors. Epilepsy Behav. 2010;17:236–41.CrossRefPubMed Baslet G, Roiko A, Prensky E. Heterogeneity in psychogenic nonepileptic seizures: understanding the role of psychiatric and neurological factors. Epilepsy Behav. 2010;17:236–41.CrossRefPubMed
Metadata
Title
Psychogenic Non-Epileptic Seizures
Authors
David K. Chen
Esha Sharma
W. Curt LaFrance Jr
Publication date
01-09-2017
Publisher
Springer US
Published in
Current Neurology and Neuroscience Reports / Issue 9/2017
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-017-0781-7

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