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Published in: BMC Emergency Medicine 1/2011

Open Access 01-12-2011 | Research article

Provider perceptions of barriers to the emergency use of tPA for Acute Ischemic Stroke: A qualitative study

Authors: William J Meurer, Jennifer J Majersik, Shirley M Frederiksen, Allison M Kade, Annette M Sandretto, Phillip A Scott

Published in: BMC Emergency Medicine | Issue 1/2011

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Abstract

Background

Only 1-3% of ischemic stroke patients receive thrombolytic therapy. Provider barriers to adhering with guidelines recommending tPA delivery in acute stroke are not well known. The main objective of this study was to describe barriers to thrombolytic use in acute stroke care.

Methods

Twenty-four hospitals were randomly selected and matched into 12 pairs. Barrier assessment occurred at intervention sites only, and utilized focus groups and structured interviews. A pre-specified taxonomy was employed to characterize barriers. Two investigators independently assigned themes to transcribed responses. Seven facilitators (three emergency physicians, two nurses, and two study coordinators) conducted focus groups and interviews of emergency physicians (65), nurses (62), neurologists (15), radiologists (12), hospital administrators (12), and three others (hospitalists and pharmacist).

Results

The following themes represented the most important external barriers: environmental and patient factors. Important barriers internal to the clinician included familiarity with and motivation to adhere to the guidelines, lack of self-efficacy and outcome expectancy. The following themes were not substantial barriers: lack of awareness of the existence of acute stroke guidelines, presence of conflicting guidelines, and lack of agreement with the guidelines.

Conclusions

Healthcare providers perceive environmental and patient-related factors as the primary barriers to adherence with acute stroke treatment guidelines. Interventions focused on increasing physician familiarity with and motivation to follow guidelines may be of highest yield in improving adherence. Improving self-efficacy in performing guideline concordant care may also be useful.

Trial Registration

ClinicalTrials.gov identifier: NCT00349479
Appendix
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Literature
1.
go back to reference Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, Hailpern SM, Ho M, Howard V, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O'Donnell C, Roger V, Sorlie P, Steinberger J, Thom T, Wilson M, Hong Y, Committee ftAHAS, Stroke Statistics Subcommittee: Heart Disease and Stroke Statistics--2008 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2008, 117 (4): e25-146.CrossRefPubMed Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, Hailpern SM, Ho M, Howard V, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O'Donnell C, Roger V, Sorlie P, Steinberger J, Thom T, Wilson M, Hong Y, Committee ftAHAS, Stroke Statistics Subcommittee: Heart Disease and Stroke Statistics--2008 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2008, 117 (4): e25-146.CrossRefPubMed
2.
go back to reference Adams HP, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A, Grubb RL, Higashida RT, Jauch EC, Kidwell C, Lyden PD, Morgenstern LB, Qureshi AI, Rosenwasser RH, Scott PA, Wijdicks EFM: Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke. 2007, 38 (5): 1655-1711. 10.1161/STROKEAHA.107.181486.CrossRefPubMed Adams HP, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A, Grubb RL, Higashida RT, Jauch EC, Kidwell C, Lyden PD, Morgenstern LB, Qureshi AI, Rosenwasser RH, Scott PA, Wijdicks EFM: Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke. 2007, 38 (5): 1655-1711. 10.1161/STROKEAHA.107.181486.CrossRefPubMed
3.
go back to reference del Zoppo GJ, Saver JL, Jauch EC, Adams HP, on behalf of the American Heart Association Stroke Council: Expansion of the Time Window for Treatment of Acute Ischemic Stroke With Intravenous Tissue Plasminogen Activator. A Science Advisory From the American Heart Association/American Stroke Association. Stroke. 2009, STROKEAHA.109.192535 del Zoppo GJ, Saver JL, Jauch EC, Adams HP, on behalf of the American Heart Association Stroke Council: Expansion of the Time Window for Treatment of Acute Ischemic Stroke With Intravenous Tissue Plasminogen Activator. A Science Advisory From the American Heart Association/American Stroke Association. Stroke. 2009, STROKEAHA.109.192535
4.
go back to reference Barber PA, Zhang J, Demchuk AM, Hill MD, Buchan AM: Why are stroke patients excluded from TPA therapy?: An analysis of patient eligibility. Neurology. 2001, 56 (8): 1015-1020.CrossRefPubMed Barber PA, Zhang J, Demchuk AM, Hill MD, Buchan AM: Why are stroke patients excluded from TPA therapy?: An analysis of patient eligibility. Neurology. 2001, 56 (8): 1015-1020.CrossRefPubMed
5.
go back to reference Schumacher HC, Bateman BT, Boden-Albala B, Berman MF, Mohr JP, Sacco RL, Pile-Spellman J: Use of Thrombolysis in Acute Ischemic Stroke: Analysis of the Nationwide Inpatient Sample 1999 to 2004. Annals of Emergency Medicine. 2007, 50 (2): 99-107. 10.1016/j.annemergmed.2007.01.021.CrossRefPubMed Schumacher HC, Bateman BT, Boden-Albala B, Berman MF, Mohr JP, Sacco RL, Pile-Spellman J: Use of Thrombolysis in Acute Ischemic Stroke: Analysis of the Nationwide Inpatient Sample 1999 to 2004. Annals of Emergency Medicine. 2007, 50 (2): 99-107. 10.1016/j.annemergmed.2007.01.021.CrossRefPubMed
6.
go back to reference Kwan J, Hand P, Sandercock P: A systematic review of barriers to delivery of thrombolysis for acute stroke. Age Ageing. 2004, 33 (2): 116-121. 10.1093/ageing/afh064.CrossRefPubMed Kwan J, Hand P, Sandercock P: A systematic review of barriers to delivery of thrombolysis for acute stroke. Age Ageing. 2004, 33 (2): 116-121. 10.1093/ageing/afh064.CrossRefPubMed
7.
go back to reference Morgenstern LB, Bartholomew LK, Grotta JC, Staub L, King M, Chan W: Sustained Benefit of a Community and Professional Intervention to Increase Acute Stroke Therapy. Arch Intern Med. 2003, 163 (18): 2198-2202. 10.1001/archinte.163.18.2198.CrossRefPubMed Morgenstern LB, Bartholomew LK, Grotta JC, Staub L, King M, Chan W: Sustained Benefit of a Community and Professional Intervention to Increase Acute Stroke Therapy. Arch Intern Med. 2003, 163 (18): 2198-2202. 10.1001/archinte.163.18.2198.CrossRefPubMed
8.
go back to reference Greco PJ, Eisenberg JM: Changing physicians' practices. N Engl J Med. 1993, 329 (17): 1271-1273. 10.1056/NEJM199310213291714.CrossRefPubMed Greco PJ, Eisenberg JM: Changing physicians' practices. N Engl J Med. 1993, 329 (17): 1271-1273. 10.1056/NEJM199310213291714.CrossRefPubMed
9.
go back to reference Cabana MD, Rand CS, Powe NR, Wu AW, Wilson MH, Abboud PA, Rubin HR: Why don't physicians follow clinical practice guidelines? A framework for improvement. Jama. 1999, 282 (15): 1458-1465. 10.1001/jama.282.15.1458.CrossRefPubMed Cabana MD, Rand CS, Powe NR, Wu AW, Wilson MH, Abboud PA, Rubin HR: Why don't physicians follow clinical practice guidelines? A framework for improvement. Jama. 1999, 282 (15): 1458-1465. 10.1001/jama.282.15.1458.CrossRefPubMed
10.
go back to reference Curry LA, Nembhard IM, Bradley EH: Qualitative and Mixed Methods Provide Unique Contributions to Outcomes Research. Circulation. 2009, 119 (10): 1442-1452. 10.1161/CIRCULATIONAHA.107.742775.CrossRefPubMed Curry LA, Nembhard IM, Bradley EH: Qualitative and Mixed Methods Provide Unique Contributions to Outcomes Research. Circulation. 2009, 119 (10): 1442-1452. 10.1161/CIRCULATIONAHA.107.742775.CrossRefPubMed
11.
go back to reference Scott PA: Enhancing Community Delivery of Tissue Plasminogen Activator in Stroke Through Community-Academic Collaborative Clinical Knowledge Translation. Emergency Medicine Clinics of North America. 2009, 27 (1): 115-136. 10.1016/j.emc.2008.07.001.CrossRefPubMedPubMedCentral Scott PA: Enhancing Community Delivery of Tissue Plasminogen Activator in Stroke Through Community-Academic Collaborative Clinical Knowledge Translation. Emergency Medicine Clinics of North America. 2009, 27 (1): 115-136. 10.1016/j.emc.2008.07.001.CrossRefPubMedPubMedCentral
12.
go back to reference Fonarow GC, Reeves MJ, Smith EE, Saver JL, Zhao X, Olson DW, Hernandez AF, Peterson ED, Schwamm LH, Committee obotG-SS, Investigators: Characteristics, Performance Measures, and In-Hospital Outcomes of the First One Million Stroke and Transient Ischemic Attack Admissions in Get With The Guidelines-Stroke. Circ Cardiovasc Qual Outcomes. 2010, 3 (3): 291-302. 10.1161/CIRCOUTCOMES.109.921858.CrossRefPubMed Fonarow GC, Reeves MJ, Smith EE, Saver JL, Zhao X, Olson DW, Hernandez AF, Peterson ED, Schwamm LH, Committee obotG-SS, Investigators: Characteristics, Performance Measures, and In-Hospital Outcomes of the First One Million Stroke and Transient Ischemic Attack Admissions in Get With The Guidelines-Stroke. Circ Cardiovasc Qual Outcomes. 2010, 3 (3): 291-302. 10.1161/CIRCOUTCOMES.109.921858.CrossRefPubMed
13.
go back to reference Leira EC, Pary JK, Davis PH, Grimsman KJ, Adams HP: Slow Progressive Acceptance of Intravenous Thrombolysis for Patients With Stroke by Rural Primary Care Physicians. Arch Neurol. 2007, 64 (4): 518-521. 10.1001/archneur.64.4.518.CrossRefPubMed Leira EC, Pary JK, Davis PH, Grimsman KJ, Adams HP: Slow Progressive Acceptance of Intravenous Thrombolysis for Patients With Stroke by Rural Primary Care Physicians. Arch Neurol. 2007, 64 (4): 518-521. 10.1001/archneur.64.4.518.CrossRefPubMed
14.
go back to reference White-Bateman SR, Schumacher HC, Sacco RL, Appelbaum PS: Consent for Intravenous Thrombolysis in Acute Stroke: Review and Future Directions. Arch Neurol. 2007, 64 (6): 785-792. 10.1001/archneur.64.6.785.CrossRefPubMed White-Bateman SR, Schumacher HC, Sacco RL, Appelbaum PS: Consent for Intravenous Thrombolysis in Acute Stroke: Review and Future Directions. Arch Neurol. 2007, 64 (6): 785-792. 10.1001/archneur.64.6.785.CrossRefPubMed
15.
go back to reference Meurer WJ, Frederiksen SM, Majersik JJ, Zhang L, Sandretto A, Scott PA: Qualitative data collection and analysis methods: the INSTINCT trial. Acad Emerg Med. 2007, 14 (11): 1064-1071.CrossRefPubMed Meurer WJ, Frederiksen SM, Majersik JJ, Zhang L, Sandretto A, Scott PA: Qualitative data collection and analysis methods: the INSTINCT trial. Acad Emerg Med. 2007, 14 (11): 1064-1071.CrossRefPubMed
16.
go back to reference Tong A, Sainsbury P, Craig J: Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Int J Qual Health Care. 2007, 19 (6): 349-357. 10.1093/intqhc/mzm042.CrossRefPubMed Tong A, Sainsbury P, Craig J: Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Int J Qual Health Care. 2007, 19 (6): 349-357. 10.1093/intqhc/mzm042.CrossRefPubMed
17.
go back to reference Campbell M, Fitzpatrick R, Haines A, Kinmonth AL, Sandercock P, Spiegelhalter D, Tyrer P: Framework for design and evaluation of complex interventions to improve health. Bmj. 2000, 321 (7262): 694-696. 10.1136/bmj.321.7262.694.CrossRefPubMedPubMedCentral Campbell M, Fitzpatrick R, Haines A, Kinmonth AL, Sandercock P, Spiegelhalter D, Tyrer P: Framework for design and evaluation of complex interventions to improve health. Bmj. 2000, 321 (7262): 694-696. 10.1136/bmj.321.7262.694.CrossRefPubMedPubMedCentral
18.
go back to reference Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, von Kummer R, Wahlgren N, Toni D, the ECASS Investigators: Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke. N Engl J Med. 2008, 359 (13): 1317-1329. 10.1056/NEJMoa0804656.CrossRefPubMed Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, von Kummer R, Wahlgren N, Toni D, the ECASS Investigators: Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke. N Engl J Med. 2008, 359 (13): 1317-1329. 10.1056/NEJMoa0804656.CrossRefPubMed
19.
go back to reference Lyden P: Thrombolytic Therapy for Acute Stroke -- Not a Moment to Lose. N Engl J Med. 2008, 359 (13): 1393-1395. 10.1056/NEJMe0806335.CrossRefPubMed Lyden P: Thrombolytic Therapy for Acute Stroke -- Not a Moment to Lose. N Engl J Med. 2008, 359 (13): 1393-1395. 10.1056/NEJMe0806335.CrossRefPubMed
20.
go back to reference Katzan IL, Furlan AJ, Lloyd LE, Frank JI, Harper DL, Hinchey JA, Hammel JP, Qu A, Sila CA: Use of Tissue-Type Plasminogen Activator for Acute Ischemic Stroke: The Cleveland Area Experience. Jama. 2000, 283 (9): 1151-1158. 10.1001/jama.283.9.1151.CrossRefPubMed Katzan IL, Furlan AJ, Lloyd LE, Frank JI, Harper DL, Hinchey JA, Hammel JP, Qu A, Sila CA: Use of Tissue-Type Plasminogen Activator for Acute Ischemic Stroke: The Cleveland Area Experience. Jama. 2000, 283 (9): 1151-1158. 10.1001/jama.283.9.1151.CrossRefPubMed
21.
go back to reference Hoffman J, Schriger D: A graphic reanalysis of the NINDS trial. Annals of Emergency Medicine. 2009, 54 (3): 329-336. 10.1016/j.annemergmed.2009.03.019.CrossRefPubMed Hoffman J, Schriger D: A graphic reanalysis of the NINDS trial. Annals of Emergency Medicine. 2009, 54 (3): 329-336. 10.1016/j.annemergmed.2009.03.019.CrossRefPubMed
22.
go back to reference Mitka M: Tensions Remain Over tPA for Stroke. JAMA. 2003, 289 (11): 1363-1364. 10.1001/jama.289.11.1363.CrossRefPubMed Mitka M: Tensions Remain Over tPA for Stroke. JAMA. 2003, 289 (11): 1363-1364. 10.1001/jama.289.11.1363.CrossRefPubMed
Metadata
Title
Provider perceptions of barriers to the emergency use of tPA for Acute Ischemic Stroke: A qualitative study
Authors
William J Meurer
Jennifer J Majersik
Shirley M Frederiksen
Allison M Kade
Annette M Sandretto
Phillip A Scott
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Emergency Medicine / Issue 1/2011
Electronic ISSN: 1471-227X
DOI
https://doi.org/10.1186/1471-227X-11-5

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