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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 1/2010

01-01-2010 | Correspondence

Proton Pump Inhibitors and Mucus Secretion

Author: Mario Guslandi

Published in: Digestive Diseases and Sciences | Issue 1/2010

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Excerpt

I have read with great interest the article by Sarosiek et al. [1] reporting a stimulatory effect of rabeprazole on esophageal mucin. The article describes a pharmacological property which may have a pivotal role in protecting the esophageal mucosa against gastro-esophageal reflux and which appears to be unique in comparison with other proton pump inhibitors (PPIs). …
Literature
1.
Sarosiek I, Olyaee M, Majewski M, , Sidorenko E, Roeser K, Sostarich S, Wallner G, Sarosiek J. Significant increase of esophageal mucin secretion in patients with reflux esophagitis after healing with rabeprazole: its esophagoprotective potential. Dig Dis Sci. 2009;54:2137–2142.CrossRefPubMed
2.
Guslandi M, Franceschi M, Fanti L, Pellegrini A, Tittobello A. Omeprazole-induced changes in gastric mucus secretion. Methods Find Exp Clin Pharmacol. 1992;14:219–223.PubMed
3.
Guslandi M, Ballarin E, Tittobello A. Gastric mucus secretion in ranitidine-treated patients. Br Med J. 1981;283:699.CrossRef
4.
Guslandi M, Battaglia A, Pamparana F, Passaretti S, Pellegrini A, Tittobello A. Weakening effect of famotidine but not of nizatidine on the mucus-bicarbonate barrier of the human stomach. Drugs Exp Clin Res. 1990;16:481–485.PubMed
Metadata
Title
Proton Pump Inhibitors and Mucus Secretion
Author
Mario Guslandi
Publication date
01-01-2010
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 1/2010
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-009-1028-5

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