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BMC Geriatrics
Published in: BMC Geriatrics 1/2022

Open Access 01-12-2022 | Study protocol

Protocol for a randomized controlled trial of mindfulness-based stress reduction to improve attentional control in older adults (HealthyAgers trial)

Authors: Ruchika Shaurya Prakash, Stephanie Fountain-Zaragoza, Megan Fisher, Oyetunde Gbadeyan, Rebecca Andridge, Janice Kiecolt-Glaser, Heena R. Manglani, Elizabeth J. Duraney, Anita Shankar, Michael R. McKenna, James Teng, Madhura Phansikar, Rosie Canter

Published in: BMC Geriatrics | Issue 1/2022

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Abstract

Background

Mindfulness meditation is a form of mind–body intervention that has increasing scientific support for its ability to reduce age-related declines in cognitive functioning, improve affective health, and strengthen the neural circuitry supporting improved cognitive and affective health. However, the majority of existent studies have been pilot investigations with small sample sizes, limited follow-up data, and a lack of attention to expectancy effects. Here, we present the study design of a Phase I/II, efficacy trial—HealthyAgers trial—that examines the benefits of a manualized mindfulness-based stress reduction program in improving attentional control and reducing mind-wandering in older adults.

Methods

One hundred fifty older adults (ages 65–85 years) will be randomized into one of two groups: an eight-week mindfulness program or an eight-week, placebo-controlled, lifestyle education program. Behavioral and neuroimaging assessments are conducted before and after the training. Participants are then invited to booster sessions once every three months for a period of 12 months with post-intervention follow-up assessments conducted at 6-months and 12-months. The primary outcomes for the study are behavioral measures of attentional control and mind-wandering. Additional, secondary outcomes include network strength in an a priori defined neuromarker of attentional control, fluid and everyday cognition, emotion regulation strategy use, and markers of inflammation.

Discussion

This study will establish the efficacy of a group-based, low-cost mind–body intervention for the inter-related facets of attentional control and mind-wandering in older adults. Strengths of this study include a well-designed, placebo-controlled comparison group, use of web/mobile application to track study adherence, and longitudinal follow-up.

Trial registration

Clinicaltrials.gov (#NCT03626532). Registered August 4, 2018.
Appendix
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Literature
1.
2.
Yaffe K, Lindquist K, Penninx BW, Simonsick EM, Pahor M, Kritchevsky S, et al. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology. 2003;61:76–80.PubMedCrossRef
3.
Weaver JD, Huang M-H, Albert M, Harris T, Rowe JW, Seeman TE. Interleukin-6 and risk of cognitive decline MacArthur studies of successful aging. Neurology. 2002;59:371–8.PubMedCrossRef
4.
De Raedt R, Ponjaert-Kristoffersen I. The relationship between cognitive/neuropsychological factors and car driving performance in older adults. J Am Geriatr Soc. 2000;48:1664–8.PubMedCrossRef
5.
Mather M, Carstensen LL. Aging and motivated cognition: the positivity effect in attention and memory. Trends Cogn Sci. 2005;9:496–502.PubMedCrossRef
6.
Mather M, Knight M. Goal-directed memory: the role of cognitive control in older adults’ emotional memory. Psychol Aging. 2005;20:554–70.PubMedCrossRef
7.
Urry HL, Gross JJ. Emotion regulation in older age. Curr Dir Psychol Sci. 2010;19:352–7.CrossRef
8.
Nashiro K, Sakaki M, Mather M. Age differences in brain activity during emotion processing: reflections of age-related decline or increased emotion regulation? Gerontology. 2012;58:156–63.PubMedCrossRef
9.
Glisky EL. Changes in Cognitive Function in Human Aging. In: Riddle DR, editor. Brain aging: models, methods, and mechanisms. Boca Raton (FL): CRC Press/Taylor & Francis; 2007. p. 3–20.
10.
Goh JO, An Y, Resnick SM. Differential trajectories of age-related changes in components of executive and memory processes. Psychol Aging. 2012;27:707–19.PubMedCrossRef
11.
Verhaeghen P, Salthouse TA. Meta-analyses of age-cognition relations in adulthood: estimates of linear and nonlinear age effects and structural models. Psychol Bull. 1997;122:231–49.PubMedCrossRef
12.
13.
Prakash RS, Erickson KI, Colcombe SJ, Kim JS, Voss MW, Kramer AF. Age-related differences in the involvement of the prefrontal cortex in attentional control. Brain Cogn. 2009;71:328–35.PubMedPubMedCentralCrossRef
14.
15.
Hasher L, Zacks RT. Working Memory, Comprehension, and Aging: A Review and a New View. In: Bower GH, editor. Psychology of learning and motivation. Academic Press; 1988. p. 193–225.
16.
De Jong R. Adult age differences in goal activation and goal maintenance. Eur J Cogn Psychol. 2001;1–2:71–89.CrossRef
17.
Gazzaley A, Cooney JW, Rissman J, D’Esposito M. Top-down suppression deficit underlies working memory impairment in normal aging. Nat Neurosci. 2005;8:1298–300.PubMedCrossRef
18.
19.
Willis SL, Tennstedt SL, Marsiske M, Ball K, Elias J, Koepke KM, et al. Long-term effects of cognitive training on everyday functional outcomes in older adults. JAMA. 2006;296:2805–14.PubMedPubMedCentralCrossRef
20.
Dunlosky J, Kubat-Silman AK, Hertzog C. Training monitoring skills improves older adults’ self-paced associative learning. Psychol Aging. 2003;18:340–5.PubMedCrossRef
21.
Rebok GW, Carlson MC, Langbaum JBS. Training and maintaining memory abilities in healthy older adults: traditional and novel approaches. J Gerontol B Psychol Sci Soc Sci. 2007;62 Spec No 1:53–61.PubMedCrossRef
22.
Fried LP, Carlson MC, Freedman M, Frick KD, Glass TA, Hill J, et al. A social model for health promotion for an aging population: Initial evidence on the experience corps model. J Urban Health. 2004;81:64–78.PubMedPubMedCentralCrossRef
23.
Park DC, Lodi-Smith J, Drew L, Haber S, Hebrank A, Bischof GN, et al. The impact of sustained engagement on cognitive function in older adults the synapse project. Psychol Sci. 2014;25:103–12.PubMedCrossRef
24.
Kabat-Zinn J. An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. Gen Hosp Psychiatry. 1982;4:33–47.PubMedCrossRef
25.
Jha AP, Stanley EA, Kiyonaga A, Wong L, Gelfand L. Examining the protective effects of mindfulness training on working memory capacity and affective experience. Emotion. 2010;10:54.PubMedCrossRef
26.
Moynihan JA, Chapman BP, Klorman R, Krasner MS, Duberstein PR, Brown KW, et al. Mindfulness-based stress reduction for older adults: effects on executive function, frontal alpha asymmetry and immune function. Neuropsychobiology. 2013;68:34–43.PubMedCrossRef
27.
Segal ZV, Bieling P, Young T, MacQueen G, Cooke R, Martin L, et al. Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depression. Arch Gen Psychiatry. 2010;67:1256–64.PubMedPubMedCentralCrossRef
28.
Baer RA, Smith GT, Lykins E, Button D, Krietemeyer J, Sauer S, et al. Construct validity of the five facet mindfulness questionnaire in meditating and non-meditating samples. Assessment. 2008;15:329–42.PubMedCrossRef
29.
Chiesa A, Serretti A. Mindfulness based cognitive therapy for psychiatric disorders: a systematic review and meta-analysis. Psychiatry Res. 2011;187:441–53.PubMedCrossRef
30.
Allen M, Dietz M, Blair KS, van Beek M, Rees G, Vestergaard-Poulsen P, et al. Cognitive-affective neural plasticity following active-controlled mindfulness intervention. J Neurosci. 2012;32:15601–10.PubMedPubMedCentralCrossRef
31.
Farb NAS, Anderson AK, Mayberg H, Bean J, McKeon D, Segal ZV. Minding one’s emotions: mindfulness training alters the neural expression of sadness. Emotion. 2010;10:25–33.PubMedPubMedCentralCrossRef
32.
Kabat-Zinn J. Wherever you go, there you are: mindfulness meditation in everyday life. New York: Hyperion; 1994.
33.
Prakash RS, Fountain-Zaragoza S, Kramer AF, Samimy S, Wegman J. Mindfulness and attention: current state-of-affairs and future considerations. J Cogn Enhanc. 2020;4:340–67.PubMedPubMedCentralCrossRef
34.
Whitmoyer P, Fountain-Zaragoza S, Andridge R, Bredemeier K, Londeree A, Kaye L, et al. Mindfulness training and attentional control in older adults: a randomized controlled trial. Mindfulness. 2020;11:203–18.CrossRef
35.
Feruglio S, Matiz A, Pagnoni G, Fabbro F, Crescentini C. The impact of mindfulness meditation on the wandering mind: a systematic review. Neurosci Biobehav Rev. 2021;131:313–30.PubMedCrossRef
36.
Scharre DW, Chang S-I, Murden RA, Lamb J, Beversdorf DQ, Kataki M, et al. Self-administered Gerocognitive Examination (SAGE): a brief cognitive assessment Instrument for mild cognitive impairment (MCI) and early dementia. Alzheimer Dis Assoc Disord. 2010;24:64–71.PubMedCrossRef
37.
Scharre DW, Chang SI, Nagaraja HN, Vrettos NE, Bornstein RA. Digitally translated Self-Administered Gerocognitive Examination (eSAGE): relationship with its validated paper version, neuropsychological evaluations, and clinical assessments. Alzheimers Res Ther. 2017;9:44.PubMedPubMedCentralCrossRef
38.
Brandt J, Benedict RHB. Hopkins verbal learning test – revised. Administration manual. Lutz: Psychological Assessment Resources; 2001.
39.
Wechsler D. Wechsler Adult Intelligence Scale-Fourth Edition (WAIS–IV). San Antonio, TX: The Psychological Corporation; 2008.
40.
Spreen O, Benton AL. Neurosensory center comprehensive examination for aphasia. Victoria BC: University of Victoria, Neuropsychology Laboratory; 1977.
41.
Kaplan E, Goodglass H, Weintraub S. The Boston Naming Test. Philadelphia, PA: Lea & Fibiger; 1983.
42.
Tien AY, Spevack TV, Jones DW, Pearlson GD, Schlaepfer TE, Strauss ME. Computerized wisconsin card sorting test: comparison with manual administration. Kaohsiung J Med Sci. 1996;12:479–85.PubMed
43.
Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9 3_Part_1:179–86.CrossRef
44.
Diagnostic and statistical manual of mental disorders, 4th ed. American Psychiatric Association, Inc.; 1994.
45.
Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999;56:303–8.PubMedCrossRef
46.
Crawford JR, Garthwaite PH, Gault CB. Estimating the percentage of the population with abnormally low scores (or abnormally large score differences) on standardized neuropsychological test batteries: a generic method with applications. Neuropsychology. 2007;21:419–30.PubMedCrossRef
47.
Palmer BW, Boone KB, Lesser IM, Wohl MA. Base rates of “Impaired” neuropsychological test performance among healthy older adults. Arch Clin Neuropsychol. 1998;13:503–11.PubMed
48.
Bondi MW, Jak AJ, Delano-Wood L, Jacobson MW, Delis DC, Salmon DP. Neuropsychological contributions to the early identification of Alzheimer’s Disease. Neuropsychol Rev. 2008;18:73–90.PubMedPubMedCentralCrossRef
49.
Jak AJ, Urban S, Mccauley A, Bangen KJ, Delano-Wood L, Corey-Bloom J, et al. Profile of hippocampal volumes and stroke risk varies by neuropsychological definition of mild cognitive impairment. J Int Neuropsychol Soc. 2009;15:890–7.PubMedPubMedCentralCrossRef
50.
Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695–9.PubMedCrossRef
51.
Radloff LS. The CES-D scale a self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1:385–401.CrossRef
52.
Kilpatrick LA, Suyenobu BY, Smith SR, Bueller JA, Goodman T, Creswell JD, et al. Impact of mindfulness-based stress reduction training on intrinsic brain connectivity. Neuroimage. 2011;56:290–8.PubMedCrossRef
53.
Brown KW, Ryan RM. The benefits of being present: mindfulness and its role in psychological well-being. J Pers Soc Psychol. 2003;84:822–48.PubMedCrossRef
54.
Gratz KL, Roemer L. Multidimensional assessment of emotion regulation and dysregulation: development, factor structure, and initial validation of the difficulties in emotion regulation scale. J Psychopathol Behav Assess. 2004;26:41–54.CrossRef
55.
Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983;24:385–96.PubMedCrossRef
56.
Whoqol Group. Development of the World Health Organization WHOQOL-BREF quality of life assessment. Psychol Med. 1998;28:551–8.CrossRef
57.
Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol. 1988;56:893–7.PubMedCrossRef
58.
Baer RA, Smith GT, Hopkins J, Krietemeyer J, Toney L. Using self-report assessment methods to explore facets of mindfulness. Assessment. 2006;13:27–45.PubMedCrossRef
59.
Lee SA. Coronavirus anxiety scale: a brief mental health screener for COVID-19 related anxiety. Death Stud. 2020;44:393–401.PubMedCrossRef
60.
Adamson MM, Phillips A, Seenivasan S, Martinez J, Grewal H, Kang X, et al. International prevalence and correlates of psychological stress during the global COVID-19 pandemic. Int J Environ Res Public Health. 2020;17:9248.PubMedCentralCrossRef
61.
Williams DR, Yu Y, Jackson JS, Anderson NB. Racial differences in physical and mental health: socio-economic status stress and discrimination. J Health Psychol. 1997;2:335–51.PubMedCrossRef
62.
Rosenberg MD, Finn ES, Scheinost D, Papademetris X, Shen X, Constable RT, et al. A neuromarker of sustained attention from whole-brain functional connectivity. Nat Neurosci. 2016;19:165–71.PubMedCrossRef
63.
64.
Rosenberg MD, Hsu W-T, Scheinost D, Todd Constable R, Chun MM. Connectome-based models predict separable components of attention in novel individuals. J Cogn Neurosci. 2018;30(2):160–73.
65.
Fountain-Zaragoza S, Samimy S, Rosenberg MD, Prakash RS. Connectome-based models predict attentional control in aging adults. Neuroimage. 2019;186:1–13.PubMedCrossRef
66.
Jangraw DC, Gonzalez-Castillo J, Handwerker DA, Ghane M, Rosenberg MD, Panwar P, et al. A functional connectivity-based neuromarker of sustained attention generalizes to predict recall in a reading task. Neuroimage. 2018;166:99–109.PubMedCrossRef
67.
Esterman M, Noonan SK, Rosenberg M, DeGutis J. In the zone or zoning out? Tracking behavioral and neural fluctuations during sustained attention. Cereb Cortex. 2013;23:2712–23.PubMedCrossRef
68.
Fortenbaugh FC, Rothlein D, McGlinchey R, DeGutis J, Esterman M. Tracking behavioral and neural fluctuations during sustained attention: a robust replication and extension. Neuroimage. 2018;171:148–64.PubMedCrossRef
69.
Gbadeyan O, Teng J, Prakash RS. Predicting response time variability from task and resting-state functional connectivity in the aging brain.: connectome-based predictive modeling of response time variability in aging. Neuroimage. 2022;250:118890.PubMedCrossRef
70.
71.
72.
Weintraub S, Dikmen SS, Heaton RK, Tulsky DS, Zelazo PD, Bauer PJ, et al. Cognition assessment using the NIH Toolbox. Neurology. 2013;80(11 Suppl 3):S54-64.PubMedPubMedCentralCrossRef
73.
Brown LB, Stern RA, Cahn-Weiner DA, Rogers B, Messer MA, Lannon MC, et al. Driving Scenes test of the Neuropsychological Assessment Battery (NAB) and on-road driving performance in aging and very mild dementia. Arch Clin Neuropsychol. 2005;20:209–15.PubMedCrossRef
74.
Stern RA, Abularach LM, Seichepine DR, Alosco ML, Gavett BE, Tripodis Y. Office-based assessment of at-risk driving in older adults with and without cognitive impairment. J Geriatr Psychiatry Neurol. 2016;29:352–60.PubMedCrossRef
75.
Ashendorf L, Alosco ML, Bing-Canar H, Chapman KR, Martin B, Chaisson CE, et al. Clinical utility of select neuropsychological assessment battery tests in predicting functional abilities in Dementia. Arch Clin Neuropsychol. 2018;33:530–40.PubMedCrossRef
76.
Stern RA, White T. NAB, Neuropsychological Assessment Battery: attention module stimulus book. Form 2. Lutz: Psychological Assessment Resources; 2003.
77.
78.
Lang PJ, Bradley MM, Cuthbert BN. International affective picture system (IAPS): Instruction manual and affective ratings. Gainsville: University of Florida, Center for Research in Psychophysiology; 1999.
79.
Sartori AC, Vance DE, Slater LZ, Crowe M. The impact of inflammation on cognitive function in older adults: implications for healthcare practice and research. J Neurosci Nurs. 2012;44:206–17.PubMedPubMedCentralCrossRef
80.
TangestaniFard M, Stough C. A review and hypothesized model of the mechanisms that underpin the relationship between inflammation and cognition in the elderly. Front Aging Neurosci. 2019;11:56.CrossRef
81.
McClintock AS, Goldberg SB, Coe CL, Zgierska AE. Mindfulness practice predicts interleukin-6 responses to a mindfulness-based alcohol relapse prevention intervention. J Subst Abuse Treat. 2019;105:57–63.PubMedPubMedCentralCrossRef
82.
Sanada K, Montero-Marin J, Barceló-Soler A, Ikuse D, Ota M, Hirata A, et al. Effects of mindfulness-based interventions on biomarkers and low-grade inflammation in patients with psychiatric disorders: a meta-analytic review. Int J Mol Sci. 2020;21:2484.PubMedCentralCrossRef
83.
Rosenkranz MA, Davidson RJ, Maccoon DG, Sheridan JF, Kalin NH, Lutz A. A comparison of mindfulness-based stress reduction and an active control in modulation of neurogenic inflammation. Brain Behav Immun. 2013;27:174–84.PubMedCrossRef
84.
Fountain-Zaragoza S, Prakash RS. Mindfulness training for healthy aging: impact on attention, well-being, and inflammation. Front Aging Neurosci. 2017;9:11.PubMedPubMedCentralCrossRef
85.
Buric I, Farias M, Jong J, Mee C, Brazil IA. What is the molecular signature of mind–body interventions? A systematic review of gene expression changes induced by meditation and related practices. Front Immunol. 2017;8:670.PubMedPubMedCentralCrossRef
86.
Creswell JD, Irwin MR, Burklund LJ, Lieberman MD, Arevalo JMG, Ma J, et al. Mindfulness-based stress reduction training reduces loneliness and pro-inflammatory gene expression in older adults: a small randomized controlled trial. Brain Behav Immun. 2012;26:1095–101.PubMedPubMedCentralCrossRef
87.
Villalba DK, Lindsay EK, Marsland AL, Greco CM, Young S, Brown KW, et al. Mindfulness training and systemic low-grade inflammation in stressed community adults: evidence from two randomized controlled trials. PLoS ONE. 2019;14:e0219120.PubMedPubMedCentralCrossRef
88.
Beydoun MA, Dore GA, Canas J-A, Liang H, Beydoun HA, Evans MK, et al. Systemic inflammation is associated with longitudinal changes in cognitive performance among urban adults. Front Aging Neurosci. 2018;10:313.PubMedPubMedCentralCrossRef
89.
Chi GC, Fitzpatrick AL, Sharma M, Jenny NS, Lopez OL, DeKosky ST. Inflammatory biomarkers predict domain-specific cognitive decline in older adults. J Gerontol A Biol Sci Med Sci. 2017;72:796–803.PubMed
90.
Walker KA, Gross AL, Moghekar AR, Soldan A, Pettigrew C, Hou X, et al. Association of peripheral inflammatory markers with connectivity in large-scale functional brain networks of non-demented older adults. Brain Behav Immun. 2020;87:388–96.PubMedPubMedCentralCrossRef
91.
Bellg AJ, Borrelli B, Resnick B, Hecht J, Minicucci DS, Ory M, et al. Enhancing treatment fidelity in health behavior change studies: best practices and recommendations from the NIH Behavior Change Consortium. Health Psychol. 2004;23:443–51.PubMedCrossRef
92.
Kechter A, Amaro H, Black DS. Reporting of treatment fidelity in mindfulness-based intervention trials: a review and new tool using NIH behavior change consortium guidelines. Mindfulness (N Y). 2019;10:215–33.CrossRef
93.
Prakash RS. Mindfulness meditation: impact on attentional control and emotion dysregulation. Arch Clin Neuropsychol. 2021;36:1283–90.PubMed
94.
Schirda B. Mindfulness training for emotion dysregulation in multiple sclerosis: a pilot randomized controlled trial. Rehabil Psychol. 2020;65:206–18.PubMedCrossRef
95.
Burton A, Burgess C, Dean S, Koutsopoulou GZ, Hugh-Jones S. How effective are mindfulness-based interventions for reducing stress among healthcare professionals? A systematic review and meta-analysis. Stress Health. 2017;33:3–13.PubMedCrossRef
96.
Khoury B, Sharma M, Rush SE, Fournier C. Mindfulness-based stress reduction for healthy individuals: a meta-analysis. J Psychosom Res. 2015;78:519–28.PubMedCrossRef
97.
Lindsay EK, Young S, Brown KW, Smyth JM, Creswell JD. Mindfulness training reduces loneliness and increases social contact in a randomized controlled trial. Proc Natl Acad Sci U S A. 2019;116:3488–93.PubMedPubMedCentralCrossRef
98.
99.
McGill JM, Burke LK, Adler-Baeder F. The dyadic influences of mindfulness on relationship functioning. J Soc Pers Relat. 2020;37:2941–51.CrossRef
100.
Verhaeghen P. Mindfulness as attention training: meta-analyses on the links between attention performance and mindfulness interventions, long-term meditation practice, and trait mindfulness. Mindfulness. 2021;12:564–81.CrossRef
101.
Boot WR, Simons DJ, Stothart C, Stutts C. The pervasive problem with placebos in psychology: why active control groups are not sufficient to rule out placebo effects. Perspect Psychol Sci. 2013;8:445–54.PubMedCrossRef
102.
103.
Murray G. Online mindfulness-based intervention for late-stage bipolar disorder: pilot evidence for feasibility and effectiveness. J Affect Disord. 2015;178:46–51.PubMedCrossRef
104.
Todd NJ, Jones SH, Lobban FA. What do service users with bipolar disorder want from a web-based self-management intervention? A qualitative focus group study: development of a web-based intervention for bipolar disorder. Clin Psychol Psychother. 2013;20:531–43.PubMedCrossRef
105.
Vieten C. The mindful moms training: development of a mindfulness-based intervention to reduce stress and overeating during pregnancy. BMC Pregnancy Childbirth. 2018;18:201.PubMedPubMedCentralCrossRef
Metadata
Title
Protocol for a randomized controlled trial of mindfulness-based stress reduction to improve attentional control in older adults (HealthyAgers trial)
Authors
Ruchika Shaurya Prakash
Stephanie Fountain-Zaragoza
Megan Fisher
Oyetunde Gbadeyan
Rebecca Andridge
Janice Kiecolt-Glaser
Heena R. Manglani
Elizabeth J. Duraney
Anita Shankar
Michael R. McKenna
James Teng
Madhura Phansikar
Rosie Canter
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2022
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-022-03334-7

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Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
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