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Published in: Current Obesity Reports 3/2020

01-09-2020 | Metabolism (M Dalamaga, Section Editor)

Protein-Rich Diets for Weight Loss Maintenance

Author: Faidon Magkos

Published in: Current Obesity Reports | Issue 3/2020

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Abstract

Purpose of Review

High-protein diets in the management of obesity have been around for many years and have been rigorously tested for their ability to induce weight loss. Comparably less is known about their effects on the maintenance of lost weight.

Recent Findings

Several small and a few large randomized trials have evaluated the efficacy of high-protein diets (20–35% of calories from protein; 1.2–1.9 g/kg∙day) compared with normal-protein diets (10–20% of calories from protein; 0.8–1.3 g/kg∙day), consumed mostly ad libitum during weight loss maintenance, i.e., after clinically significant weight loss. Most of these studies indicate that weight regain in the short term (3–12 months) is lower by 1–2 kg with high-protein diets than low-protein diets. This effect is attenuated with longer periods of observation, likely because of decreasing dietary compliance.

Summary

In line with findings during the active weight loss phase, studies assessing the efficacy of protein-rich diets to improve weight loss maintenance report beneficial effects in the short term, which nevertheless dissipate over time.
Literature
3.
go back to reference Komlos J, Brabec M. The trend of BMI values of US adults by centiles, birth cohorts 1882–1986. NBER Working Paper. No 16252. 2010. Komlos J, Brabec M. The trend of BMI values of US adults by centiles, birth cohorts 1882–1986. NBER Working Paper. No 16252. 2010.
15.
go back to reference • Pascual RW, Phelan S, La Frano MR, Pilolla KD, Griffiths Z, Foster GD. Diet quality and micronutrient intake among long-term weight loss maintainers. Nutrients. 2019;11:3046. https://doi.org/10.3390/nu11123046An observational study that shows that individuals who are succesful in maintaining clinically significant weight loss in the long term (on average, 29.7 kg for 3.4 years) consume a diet which is relatively rich in protein and carbohydrate and relatively poor in dietraty fat, compared with a control group of subject with obesity.CrossRefPubMedCentral • Pascual RW, Phelan S, La Frano MR, Pilolla KD, Griffiths Z, Foster GD. Diet quality and micronutrient intake among long-term weight loss maintainers. Nutrients. 2019;11:3046. https://​doi.​org/​10.​3390/​nu11123046An observational study that shows that individuals who are succesful in maintaining clinically significant weight loss in the long term (on average, 29.7 kg for 3.4 years) consume a diet which is relatively rich in protein and carbohydrate and relatively poor in dietraty fat, compared with a control group of subject with obesity.CrossRefPubMedCentral
19.
go back to reference •• Kjolbaek L, Sorensen LB, Sondertoft NB, Rasmussen CK, Lorenzen JK, Serena A, et al. Protein supplements after weight loss do not improve weight maintenance compared with recommended dietary protein intake despite beneficial effects on appetite sensation and energy expenditure: a randomized, controlled, double-blinded trial. Am J Clin Nutr. 2017;106:684–97. https://doi.org/10.3945/ajcn.115.129528A well-conducted randomized controlled trial of protein supplementation during weight loss maintenance. Results showed that protein supplementation over 6 months did not affect changes in body weight and body composition compared with normal protein intake, even though it increased postprandial thermogenesis and augmented appetite.CrossRefPubMed •• Kjolbaek L, Sorensen LB, Sondertoft NB, Rasmussen CK, Lorenzen JK, Serena A, et al. Protein supplements after weight loss do not improve weight maintenance compared with recommended dietary protein intake despite beneficial effects on appetite sensation and energy expenditure: a randomized, controlled, double-blinded trial. Am J Clin Nutr. 2017;106:684–97. https://​doi.​org/​10.​3945/​ajcn.​115.​129528A well-conducted randomized controlled trial of protein supplementation during weight loss maintenance. Results showed that protein supplementation over 6 months did not affect changes in body weight and body composition compared with normal protein intake, even though it increased postprandial thermogenesis and augmented appetite.CrossRefPubMed
21.
go back to reference Aller EE, Larsen TM, Claus H, Lindroos AK, Kafatos A, Pfeiffer A, et al. Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index: the DIOGENES trial 12-month results. Int J Obes. 2014;38:1511–7. https://doi.org/10.1038/ijo.2014.52.CrossRef Aller EE, Larsen TM, Claus H, Lindroos AK, Kafatos A, Pfeiffer A, et al. Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index: the DIOGENES trial 12-month results. Int J Obes. 2014;38:1511–7. https://​doi.​org/​10.​1038/​ijo.​2014.​52.CrossRef
26.
go back to reference • Christensen P, Meinert Larsen T, Westerterp-Plantenga M, Macdonald I, Martinez JA, Handjiev S, et al. Men and women respond differently to rapid weight loss: Metabolic outcomes of a multi-centre intervention study after a low-energy diet in 2500 overweight, individuals with pre-diabetes (PREVIEW). Diabetes Obes Metab. 2018;20:2840–51. https://doi.org/10.1111/dom.13466A description of the results of the initial weight loss phase of the PREVIEW trial; the largest randomized study on the effects of protein supplementation on weight loss maintenance.CrossRefPubMedPubMedCentral • Christensen P, Meinert Larsen T, Westerterp-Plantenga M, Macdonald I, Martinez JA, Handjiev S, et al. Men and women respond differently to rapid weight loss: Metabolic outcomes of a multi-centre intervention study after a low-energy diet in 2500 overweight, individuals with pre-diabetes (PREVIEW). Diabetes Obes Metab. 2018;20:2840–51. https://​doi.​org/​10.​1111/​dom.​13466A description of the results of the initial weight loss phase of the PREVIEW trial; the largest randomized study on the effects of protein supplementation on weight loss maintenance.CrossRefPubMedPubMedCentral
32.
go back to reference Weigle DS, Breen PA, Matthys CC, Callahan HS, Meeuws KE, Burden VR, et al. A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations. Am J Clin Nutr. 2005;82:41–8. https://doi.org/10.1093/ajcn.82.1.41.CrossRefPubMed Weigle DS, Breen PA, Matthys CC, Callahan HS, Meeuws KE, Burden VR, et al. A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations. Am J Clin Nutr. 2005;82:41–8. https://​doi.​org/​10.​1093/​ajcn.​82.​1.​41.CrossRefPubMed
33.
go back to reference Leaf A, Antonio J. The effects of overfeeding on body composition: the role of macronutrient composition - a narrative review. Int J Exerc Sci. 2017;10:1275–96.PubMedPubMedCentral Leaf A, Antonio J. The effects of overfeeding on body composition: the role of macronutrient composition - a narrative review. Int J Exerc Sci. 2017;10:1275–96.PubMedPubMedCentral
34.
go back to reference Webb P, Annis JF. Adaptation to overeating in lean and overweight men and women. Hum Nutr Clin Nutr. 1983;37:117–31.PubMed Webb P, Annis JF. Adaptation to overeating in lean and overweight men and women. Hum Nutr Clin Nutr. 1983;37:117–31.PubMed
Metadata
Title
Protein-Rich Diets for Weight Loss Maintenance
Author
Faidon Magkos
Publication date
01-09-2020
Publisher
Springer US
Published in
Current Obesity Reports / Issue 3/2020
Electronic ISSN: 2162-4968
DOI
https://doi.org/10.1007/s13679-020-00391-0

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